Endoscopic diagnosis of early gastric cancer by the endoscopic congo red-methylene blue test

Tatsuta, Masaharu; Okuda, Shujiro; Tamura, Hiroshi; Taniguchi, Haruo

doi:10.1002/1097-0142(19821215)50:12<2956::aid-cncr2820501242>3.0.co;2-a

Cited by 50 publications

(18 citation statements)

References 6 publications

(3 reference statements)

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“…Above all, it is worth mentioning that the frequency of lymph node metastasis was similar in the two groups. Lymph node metastasis is the most reliable prognostic factor in gastric cancers when the depth of invasion is similar (Maruyama et al, 1987;Hioki et al, 1990;Maehara et al, 1992;Sano et al, 1992 Recent advances in diagnostic techniques allowed us to determine preoperative and intraoperative staging of gastric cancer (Tatsuta et al, 1982;Yasuda et al, 1986;Tio et al, 1989). In particular, endoscopic ultrasonography and intraoperative histological examination are useful for more objective determination of the depth of invasion for gastric cancer, which is strongly correlated with patients' survival time (Maruyama et al, 1989;Kitamura et al, 1996c).…”

Section: Methodsmentioning

confidence: 99%

Early gastric cancer mimicking advanced gastric cancer

Kitamura

Yamaguchi²,

Nishida³

et al. 1997

Br J Cancer

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Summary The clinicopathological features of 37 early gastric cancers mimicking advanced gastric cancer were reviewed retrospectively, and were compared with 596 other early gastric cancers and 126 mp gastric cancers, defined as gastric cancer invading the muscularis propria of the stomach. A greater tumour size (P < 0.005), submucosal invasion (P < 0.005), lymph node and lymph vessel invasion (P < 0.005) and vascular invasion (P < 0.025) were found more frequently in early gastric cancers mimicking advanced gastric cancers than in other early gastric cancers. There were no significant differences in the clinicopathological findings between early gastric cancers mimicking advanced gastric cancers and mp gastric cancers. Patients with early gastric cancers mimicking advanced gastric cancers showed a lower survival rate than patients with other early gastric cancers, but a higher survival than those with mp gastric cancers. The macroscopic appearance of an advanced gastric cancer was an indicator of massive submucosal invasion and lymph node metastasis in early gastric cancer. As early gastric cancers mimicking advanced gastric cancers showed similar clinicopathological findings to mp gastric cancers, these cancers should be treated as mp gastric cancers.

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Section: Methodsmentioning

confidence: 99%

Early gastric cancer mimicking advanced gastric cancer

Kitamura

Yamaguchi²,

Nishida³

et al. 1997

Br J Cancer

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“…11,12 In addition, it is reported that a consecutive application with methylene blue enables distinction stomach areas altered by the tumor from their surroundings. 13 Therefore, in our study, Congo red is applied after application of indigo carmine. With this staining, carcinoma tissue was bleached out, while surrounding connective and muscle tissues were stained as brown-black.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of intraoperative tissue staining in delineating deep surgical margins in oral carcinoma surgery

Kitamura¹,

Sakai²,

Kamata³

et al. 2008

Oral Oncology

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Abstract:The purpose of this study was to assess the accuracy of this tissue staining assessment of surgical specimens in delineating deep surgical margins in oral cancer surgery. Fifteen patients who underwent surgery for oral carcinoma were included in the study. Once the tumor was resected, a vertical section of the surgical specimen was taken from the central part of the tumor. The section was consecutively stained with 0.4% indigo carmine and 0.5% Congo red, and deep surgical margins were assessed using a digital microscope with a magnification power of 25 to 175x. The results of tissue-staining analysis were compared with the corresponding results of conventional histopathological analysis with HE staining, which is considered the gold standard. The extent of carcinoma invasion could be visualized after the application of tissue-staining solutions. Tissue-staining analysis was accurate in 12 of the 15 patients (80%) in evaluating the closest deep surgical margin. There was no significant difference in the tumor-margin distance between tissue staining and histopathological assessment in these 12 patients (Wilcoxon signed-ranks test, P>0.63). The results of this study showed that intraoperative tissue staining of surgical specimens permitted visual inspection and assessment of tumor spread to surgical margin, although the method has some limitations. The method had a possible ability in controlling the deep surgical margin.

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“…In consecutive application with methylene blue, stomach areas altered by the tumor are bleached out, thus making them distinguishable from their surroundings. 8 In this study, Congo red was applied after indigo carmine. This consecutive staining enabled demarcation of the extent of tumor invasion; that is, carcinoma tissue was bleached out, while the surrounding connective and muscle tissues were stained brown-black.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative Tissue Staining of Invaded Oral Carcinoma

Kitamura

Kamata

Koike

et al. 2008

Pathol. Oncol. Res.

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Abstract:The purpose of this study was to assess the ability of intraoperative tissue staining with consecutive application of 0.4% indigo carmine and 0.5% Congo red to demonstrate the extent and border of oral carcinoma invasion. Seventeen patients were included in the study. Once the oral tumor was resected, a vertical section of surgical specimen was taken from the central part of the tumor. The extent and border of the invaded carcinoma were assessed on digital microscopic examination with tissue staining. The results of assessments were compared with corresponding results of conventional histopathological analysis with HE staining, which is considered the gold standard. Tissue staining produced a brown-black stain on normal muscle, connective, and salivary tissues but not tumor and epithelial tissues. It clearly demonstrated the extent and border of tumor invasion in 13 of 17 patients (76.5%); however, detection of remnant vital tumor cells in scar tissue after neoadjuvant chemotherapy, and distinction between the tumor and adipose tissue scattered in the muscle tissue was difficult. The results of this study showed that intraoperative tissue staining was a possible method in demonstrating the extent and border of carcinoma deeply invaded in the soft tissue and selecting the site for additional frozen section analysis, although the method needed some refinement.

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Endoscopic diagnosis of early gastric cancer by the endoscopic congo red-methylene blue test

Cited by 50 publications

References 6 publications

Early gastric cancer mimicking advanced gastric cancer

Early gastric cancer mimicking advanced gastric cancer

Accuracy of intraoperative tissue staining in delineating deep surgical margins in oral carcinoma surgery

Intraoperative Tissue Staining of Invaded Oral Carcinoma

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