Endorphins–A Novel Hidden Magic Holistic Healer

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“…In the CNS, binding of betaendorphin to the mu receptors situated on central nervous system results in inhibition of GABA inhibitary neurotransmitter, produce dopamine neurotransmitter involved in analgesic activity, stress buster activity, euphoria, cognitive development, self reward, addiction, and tranquility of mind [6][7][8][9]. Endorphin receptors situated on most immune cells.…”

“…Endorphin receptors situated on most immune cells. Binding of betaendorphin to the µ receptors situated on most innate and adaptive immune cells such as a neutrophils, macrophages, mast cells, Natural killer cells, dendritic cells, T cells, and B cells results in inhibition of inflammatory mediators such as IL-1β,TNF-α, and IL-6 pro-inflammatory cytokines, activation of innate and adaptive immune cells (immune stimulatory activity) release opsonin, granzyme-b, IFN-Gamma, and antibodies involved in antiviral cativity, antibacterial activity, antitumor activity, and anti-inflammatory activity [6][7][8].…”

“…Betaendorphin inhibits chronic psychological stress induced activation of sympathetic nervous system and activation of parasympathetic nervous system of ANS (Autonomic nervous system) through inhibition of HPA-axis, mediated release of neuropeptides such as cortisol, noradrenaline and ACTH, inhibit inflammatory mediators such as IL-1β, IL-6, TNF-α, and COX-2, which inhibits NF-KB, STAT3 key transcruiption factors involved in chronic inflammation associated cancer [5][6][7][8][10][11][12][13][14][15].…”

“…Betaendorphin inhibits chronic inflammatory mediators induced activation of NF-KB a key transcription factor involved in tumor progression, which antagonize P53 tumor suppressor gene,a guardian of the genome mutated in more than 50% of all cancers by inflammatory mediators such as NO (Nitric oxide), ROS, RNS free radicals, AID (Activation induced cytidine deaminase) enzyme expressed by NF-KB key transcription factor. Betaendorphin express epithelial E cadherin helps in epithelial cell adhesion, loss of epithelial E-cadherin mediated epithelial to mesenchymal transition induced tumor invasion [6][7][8]16,17]. Betaendorphin involved in lengethening telomeres which otherwise shorten with aging.…”

“…There are three types of endorphins betaendorphin, enkephalin, and dynorphin binds to mu, kappa, and delta receptors situated on nervous system and immune cells. Betaendorphin is an abundant endorphin, more potent than morphine, synthesized and stored in the anterior pituitary gland, it is a precursor of POMC (Proopiomelanocortin) [1][2][3][4][5][6][7].…”