Ureteropelvic junction obstruction (UPJO) is a well-known pathologic condition with several potential associated urologic complications. The treatment for UPJO has evolved dramatically during the past two decades with the advent of minimally invasive treatment options. This has resulted in shorter hospital stays, reduced postoperative pain, and quicker convalescence compared with the gold standard, open pyeloplasty. Antegrade (percutaneous) endopyelotomy is one of the many minimally invasive treatment options for this disorder. In this article, we review the technical aspects, outcomes, and current role of antegrade endopyelotomy in the treatment of UPJO.