Endoplasmic reticulum stress response mediated by the PERK-eIF2α-ATF4 pathway is involved in odontoblastic differentiation of human dental pulp cells

Li, Lifen; Yang, Wen; Jiang, Long; Zhu, Yaqin

doi:10.1016/j.archoralbio.2021.105312

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Regulation Of Xbp1 In Osteoblast Differentiation1

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2023

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Cited by 2 publications

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“…Disturbances in tissue homeostasis can initiate the osteogenic differentiation of PDLCs. RT-PCR of osteogenesis-induced PDLCs revealed that PDLCs undergo upregulation of ER stress levels during the osteogenic differentiation process and that XBP1 plays a role in it ( 50 , 51 ).…”

Section: Regulation Of Xbp1 In Osteoblast Differentiationmentioning

confidence: 99%

The Role of XBP1 in bone metabolism

Lv,

Zheng,

Jiao

et al. 2023

Front. Endocrinol.

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Bone is a dynamic organ that, once formed, undergoes a constant remodeling process that includes bone resorption and synthesis. Osteoclasts and osteoblasts are primarily responsible for controlling this process. X-box binding protein 1 (XBP1), a transcription factor, affects the metabolism of bones in various ways. In recent years, numerous studies have revealed that XBP1 plays a vital role in bone metabolism, including osteoclast and osteoblast development, as well as in regulating immune cell differentiation that affects the immune microenvironment of bone remodeling. In this review, we highlight the regulatory mechanisms of XBP1 on osteoclasts and osteoblasts, how XBP1 affects the immune microenvironment of bone remodeling by influencing the differentiation of immune cells, and predict the possible future research directions of XBP1 to provide new insights for the treatment of bone-related metabolic diseases.

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Section: Regulation Of Xbp1 In Osteoblast Differentiationmentioning

confidence: 99%