Endophytic taxol-producing fungi from bald cypress, Taxodium distichum

Li, Jiayao; Strobel, Gary A.; Sidhu, Rajinder S.; Hess, W. M.; Ford, Eugene

doi:10.1099/13500872-142-8-2223

Cited by 218 publications

(122 citation statements)

References 10 publications

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“…54,57 Fungi such as Taxomyces andreanae, Pestalotiopsis microspora, Tubercularia sp., Phyllosticta citricarpa, Nodulisporium sylviforme, Colletotrichum gloeosporoides, Colletotrichum annutum, Fusarium maire and Pestalotiopsis versicolor produce it. 54,[58][59][60][61][62][63][64] The endophyte F. maire produces 225 μg l − 1 . Production by P. citricarpa amounted to 265 μg l − 1 .…”

Section: Antineoplastic Drugsmentioning

confidence: 99%

Production of valuable compounds by molds and yeasts

Demain

Martens

2016

J Antibiot

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where he has contributed in a major way to the reputation of this department for many years. He also served as an Adjunct Professor at the University of Geneva. Among Julian's areas of study and accomplishment are fungal toxins including α-sarcin, chemical synthesis of triterpenes, mode of action of streptomycin and other aminoglycoside antibiotics, biochemical mechanisms of antibiotic resistance in clinical isolates of bacteria harboring resistance plasmids, their origins and evolution, secondary metabolism of microorganisms, structure and function of bacterial ribosomes, antibiotic resistance mutations in yeast ribosomes, cloning of resistance genes from an antibiotic-producing microbe, gene cloning for industrial purposes, engineering of herbicide resistance in useful crops, bleomycin-resistance gene in clinical isolates of Staphylococcus aureus and many other topics. He has been an excellent teacher, lecturing in both English and French around the world, and has organized international courses. Julian has also served on the NIH study sections, as Editor for several international journals, and was one of the founders of the journal Plasmid. We expect the impact of Julian's accomplishments to continue into the future.

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Section: Antineoplastic Drugsmentioning

confidence: 99%

Production of valuable compounds by molds and yeasts

Demain

Martens

2016

J Antibiot

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“…Its ethyl acetate extract displayed significant antifungal activities against three plant pathogens, Fusarium graminearum, Botrytis cinerea and Phytophthora nicotianae. Bioassay-directed fractionation of this extract has led to the isolation of nine phthalide derivatives (1-9) including three new ones (1)(2)(3). Compounds (1-9) displayed significant antifungal activities against the above three plant pathogens ( Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae

Yang

Zhang

et al. 2011

J Antibiot

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Three new phthalide derivatives (1-3) named 5-(3¢-methyl-2¢-butenyl)-2-hydroxy-3-methoxy-4-methylbenzoic acid (1), 5-(3¢-carboxyl-3¢-methyl-2E-allyloxy)-3-methoxy-4-methylphthalide (2) and 5-(3¢,3¢-dimethylallyloxy)-2-methoxycarbonyl-3-methoxy-4-methylbenzoic acid (3) together with six known phthalide derivatives named 5-(3¢,3¢-dimethylallyloxy)-3-methoxy-4-methylphthalide (4), zinnimidine (5), 5-(3¢,3¢-dimethylallyloxy)-3-methoxy-4-methylphthalide (6), 5-(3¢,3¢-dimethylallyloxy)-3-methoxy-4-methylphthalic acid (7), zinniol anhydride (8) and porriolide (9) were isolated from the liquid culture of the plant endophytic fungus Pestalotiopsis photiniae isolated from the Chinese Podocarpaceae plant Podocarpus macrophyllus. Their structures were elucidated by extensive spectroscopic analysis. Compounds 1-9 displayed significant antifungal activities against three plant pathogens.

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“…The isolation of Taxol-producing endophyte Taxomyces anderanae has provided a different approach to find a cheaper and additional product via microorganism fermentation [130]. Taxol has also been found in a amount of unusual genera of fungal endophytes either related or not to yews, such as Taxodium distichum [93] ;Wollemia nobilis [134]., Phyllosticta spinarum [94]; Bartalinia robillardoides [42] ;Pestalotiopsis terminaliae [42] ;Botryodiplodia theobromae [95].…”

Section: Anticancer Compoundsmentioning

confidence: 99%