Endophytes as sources of antibiotics

Martinez-Klimova, Elena; Rodríguez-Peña, Karol; Sánchez, Sergio

doi:10.1016/j.bcp.2016.10.010

Cited by 183 publications

(108 citation statements)

References 70 publications

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“…3). As reported previously [17], 99 % of fungal genera isolated as endophytes belong to the Ascomycota and Basidiomycota phylum, with the dominance of Ascomycota isolates (~85 %) (▶ Fig. 3).…”

Section: Diversity Of Endophytes In Brazilsupporting

confidence: 76%

“…Andrioli et al [56] demonstrated that the new mycoleptones are non-selective compounds with antileishmanial and cytotoxic activities. Secondary metabolites produced by endophytes, in general, are less toxic to eukaryotes than to prokaryotes, since endophytes should not harm the host plant [17]. This is especially true if we compare the number of compounds with antibacterial activity (16) with those showing antifungal activity (8) (▶ Table 3).…”

Section: Eugenitin [63]mentioning

confidence: 99%

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2019

Planta Med

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Section: Diversity Of Endophytes In Brazilsupporting

confidence: 76%

Section: Eugenitin [63]mentioning

confidence: 99%

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2019

Planta Med

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“…In developing biocontrol agents to treat plant fungal pathogenic diseases, many different organisms could be utilized. Various actinomycetes species are known to have antagonistic activities against many pathogenic microorganisms (Moussa et al, 2011;Ahmad et al, 2017;Martinez-Klimova, Rodriguez-Pena & Sánchez, 2017;Sadeghi et al, 2017;Fabrizius et al, 2018). Many actinomycetes can produce antifungal or antibacterial compounds or out-compete the pathogens (El-Tarabily & Sivasithamparam, 2006;Gomes, Duarte & De Freire Bastos do, 2017;Lee et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Biocontrol of chocolate spot disease (Botrytis cinerea) in faba bean using endophytic actinomycetesStreptomyces: a field study to compare application techniques

El-Shatoury

Ameen

Moussa

et al. 2020

PeerJ

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Sustainable agriculture is needing economic applications for disease control. One possibility is offered by local medical plants. Endophytes of medical plants, such as actinomycetes Streptomyces sp. have previously shown antagonistic activities against fungal phytopathogens. In the present field experiment, we aimed to verify the efficiency of endophytic Streptomyces against one of the common pathogens, Botrytis cinerea, causing chocolate spot disease for faba bean (Vicia fabae L.). We tested two strains of Streptomyces (MG788011, MG788012) and three techniques to apply the biocontrol agent: (1) coating the seeds with spores, (2) spraying mycelia and (3) spraying the crude metabolites over the plants. The technique using the crude metabolites was the most efficient to prevent the disease symptoms. Both of the endophytic strains diminished the disease symptoms and improved the plant growth. The study offers a potential biological control technique to prevent chocolate spot disease and, at the same time, increase the yields of faba bean in sustainable agriculture.

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“…88–90 Living within plant tissue “endophytic” bacteria or fungi have been associated with vast numbers of bioactive compounds and have been found to be extraordinarily ubiquitious; to date, not one study has shown the existence of a plant species devoid of endophytes and it is common for a single host plant species to house 30 or more endophytic microbes, especially fungi. 88 The precise workings, habitats, capabilities and other qualities of endophytic organisms have been delineated and reviewed in great detail by Sanchez 91 and Suryanarayanan. 92 Cragg and Newman have surveyed medicinally important compounds arising from endophytes as well as epiphytic fungi (that reside on, rather than in, plant hosts) and root-associated microbes paying special attention to NPs such as taxol, maytansine, and assorted ergot alkaloids among others whose stories of discovery and advancement have much to do with their production by one or more of these kinds of putative plant-based symbiont pairings.…”

Section: Plant-microbe Symbiosesmentioning

confidence: 99%

Symbiosis-inspired approaches to antibiotic discovery

Adnani

Rajski

2017

Nat. Prod. Rep.

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Life on Earth is characterized by a remarkable abundance of symbiotic and highly refined relationships among life forms. Defined as any kind of close, long-term association between two organisms, symbioses can be mutualistic, commensalistic or parasitic. Historically speaking, selective pressures have shaped symbioses in which one organism (typically a bacterium or fungus) generates bioactive small molecules that impact the host (and possibly other symbionts); the symbiosis is driven fundamentally by the genetic machineries available to the small molecule producer. The human microbiome is now integral to the most recent chapter in animal-microbe symbiosis studies and plant-microbe symbioses have significantly advanced our understanding of natural products biosynthesis; this also is the case for studies of fungal-microbe symbioses. However, much less is known about microbe-microbe systems involving interspecies interactions. Microbe-derived small molecules (i.e. antibiotics and quorum sensing molecules, etc.) have been shown to regulate transcription in microbes within the same environmental niche, suggesting interspecies interactions whereas, intraspecies interactions, such as those that exploit autoinducing small molecules, also modulate gene expression based on environmental cues. We, and others, contend that symbioses provide almost unlimited opportunities for the discovery of new bioactive compounds whose activities and applications have been evolutionarily optimized. Particularly intriguing is the possibility that environmental effectors can guide laboratory expression of secondary metabolites from “orphan”, or silent, biosynthetic gene clusters (BGCs). Notably, many of the studies summarized here result from advances in “omics” technologies and highlight how symbioses have given rise to new anti-bacterial and antifungal natural products now being discovered.

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Endophytes as sources of antibiotics

Cited by 183 publications

References 70 publications

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Biocontrol of chocolate spot disease (Botrytis cinerea) in faba bean using endophytic actinomycetesStreptomyces: a field study to compare application techniques

Symbiosis-inspired approaches to antibiotic discovery

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