Endometrium from women with endometriosis shows increased proliferation activity

Park, Jae Sun; Lee, Jae Hoon; Kim, Miran; Chang, Hye Jin; Hwang, Kyu Ri; Chang, Ki‐Hong

doi:10.1016/j.fertnstert.2009.04.025

Cited by 66 publications

(54 citation statements)

References 16 publications

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“…Furthermore, of the 105 patients after hysteroscopic polypectomy, the patients in the early stages (stages I and II) of endometriosis achieved significantly higher clinical pregnancy than those in the advanced stages ( In this study, endometrial polyps were identified in 164 out of 431 infertile patients with a significantly higher prevalence in patients with endometriosis. This result was similar to findings in earlier studies (7,9). Advanced stages of endometriosis showed a higher prevalence of endometrial polyps, and the frequency was significantly elevated at each stage of endometriosis compared with the control participants.…”

supporting

confidence: 91%

“…It is not known whether endometrial polyps are a risk factor or an etiologic factor in endometriotic infertility, and there are very few reports in the literature that investigate this association. Several studies have shown a higher frequency of endometrial polyps in patients with endometriosis compared with those without the disease (7)(8)(9). Other investigators have revealed an increased presence of pelvic or peritoneal endometriosis in patients who had suspected endometrial polyps on hysterosalpingography (10,11).…”

mentioning

confidence: 99%

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High prevalence of endometrial polyps in endometriosis-associated infertility

Shen

Wang

Huang

et al. 2011

Fertility and Sterility

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supporting

confidence: 91%

mentioning

confidence: 99%

High prevalence of endometrial polyps in endometriosis-associated infertility

Shen

Wang

Huang

et al. 2011

Fertility and Sterility

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“…The resistance of endometrial cells to apoptosis and their increased sensitivity to proliferation is one of the proposed theories for the development of endometriosis (Harada et al 2004). Intrinsic resistance of refluxed endometrial cells to apoptosis may promote their adherence to the peritoneal mesothelial cells, thereby provoking cell proliferation and neoangiogenesis to develop active endometriosis (Park et al 2009). Meresman et al (2000) confirmed the pathological role of apoptosis in endometriosis by detecting up-regulated expression of the anti-apoptotic factor BCL2 that is accompanied by reduced expression of the pro-apoptotic factor BAX.…”

Section: R202 L Pirdel and M Pirdelmentioning

confidence: 99%

Role of iron overload-induced macrophage apoptosis in the pathogenesis of peritoneal endometriosis

Pirdel¹,

Pirdel²

2014

Reproduction

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This article presents an overview of the involvement of iron overload-induced nitric oxide (NO) overproduction in apoptosis of peritoneal macrophages of women with endometriosis. We have postulated that the peritoneal iron overload originated from retrograde menstruation or bleeding lesions in the ectopic endometrium, which may contribute to the development of endometriosis by a wide range of mechanisms, including oxidative damage and chronic inflammation. Excessive NO production may also be associated with impaired clearance of endometrial cells by macrophages, which promotes cell growth in the peritoneal cavity. Therefore, further research of the mechanisms and consequences of macrophage apoptosis in endometriosis helps discover novel therapeutic strategies that are designed to prevent progression of endometriosis.

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“…Some studies have shown that patients with endometriosis usually have a high prevalence of endometrial polyps [15-18]. The size and number of endometrial polyps in patients in the endometriosis group were not correlated with the r-AFS stage [19].…”

Section: Introductionmentioning

confidence: 99%

Higher Prevalence of Endometrial Polyps in Infertile Patients with Endometriosis

Zhang

et al. 2018

Gynecol Obstet Invest

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Aim: To study whether infertile patients with endometriosis have a higher prevalence of endometrial polyps, and to clarify the characteristics of the pathology of combined polyps. Methods: Infertile patients who had undergone both hysteroscopy and laparoscopy in Reproductive Hospital Affiliated with Shandong University from January 2014 to May 2017 were enrolled. Patients with and without endometriosis, diagnosed by laparoscopy, were staged and included in the study group and control group, respectively, and the prevalence of polyps was compared. The pathological types of endometrial polyps were analyzed. Results: A total of 414 cases were enrolled in the study group and 3,048 cases in the control group; polyps were diagnosed, with endoscopy, in 1,107 patients. Endometrial polyps were detected by hysteroscopy in 47.83% of the endometriosis group and 29.82% of the control group. The prevalence of endometrial polyps was significantly higher in the endometriosis group than in the control group (p < 0.001) but not significantly different between stages of endometriosis (p = 0.580). The pathological diagnosis included 899 endometrial polyps and 208 polypoid hyperplasia; 66.5% of endometrial polyps were combined with simple hyperplasia. Conclusions: The infertile patients with endometriosis had a higher prevalence of endometrial polyps, and those polyps are often combined with simple hyperplasia.

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Endometrium from women with endometriosis shows increased proliferation activity

Cited by 66 publications

References 16 publications

High prevalence of endometrial polyps in endometriosis-associated infertility

High prevalence of endometrial polyps in endometriosis-associated infertility

Role of iron overload-induced macrophage apoptosis in the pathogenesis of peritoneal endometriosis

Higher Prevalence of Endometrial Polyps in Infertile Patients with Endometriosis

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