Endometriosis-associated changes in serum levels of interferons and chemokines

Măluţan, Andrei Mihai; Drugan, Tudor; Ciortea, Răzvan; Bucuri, Carmen Elena; Rada, Maria Patricia; Mihu, Dan

doi:10.3906/sag-1507-185

Cited by 20 publications

(9 citation statements)

References 32 publications

(40 reference statements)

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“…Unfortunately, IL-8 was excluded in the present study due to technical problems. Previous studies have reported significantly lower concentrations of the closely related CXCL9 and CXCL10 (also called IP-10) in peripheral blood in endometriosis [18,19,20], in line with the present study. There is increased expression of MMP-9 in endometrium [21] and in peritoneal fluid in endometriosis [22], and MMP-9 cleaves CXCL9 at three different sites and degrades CXCL10 [23].…”

Section: Discussionsupporting

confidence: 93%

“…We could not find any studies regarding the impact of menopause on the proteins that differed the most. Generally, several cytokines are elevated in postmenopausal women, e.g., IL-1β, IL-6, and IL-8, which is why the actual estimated differences may be underestimated [20,33,34]. The phase of the menstrual cycle was neither known in controls nor in endometriosis, but the majority of endometriosis patients were on continuous hormonal treatment affecting the cycle.…”

Section: Discussionmentioning

confidence: 99%

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AXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis

Roth

Engström

et al. 2019

IJMS

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Although endometriosis is considered an inflammatory disease, no reliable diagnostic biomarkers exist for use in clinical practice. The aim was to investigate the inflammatory profile in endometriosis using an exploratory approach of inflammation-related proteins. Patients with laparoscopy-verified endometriosis (N = 172), women with microscopic colitis (N = 50), healthy controls (N = 31), and age-matched controls from the general population (N = 100) were enrolled and questionnaires regarding socioeconomic factors, lifestyle habits, and medical history were completed. Sera from patients and healthy controls were analyzed for 92 inflammatory biomarkers using Proximity Extension Assay technology (PEA). Plasma AXIN1 levels were analyzed in patients with endometriosis and controls from the general population by ELISA. General linear model adjusted for age, Mann–Whitney U-test, and principal component analysis (PCA) were used for statistical calculations. Serum levels of AXIN1 and ST1A1 were increased in endometriosis compared with MC (p < 0.001) and healthy controls (p = 0.001), whereas CXCL9 levels were decreased. Plasma levels of AXIN1 were elevated in endometriosis compared with age-matched controls from the general population (30.0 (17.0–38.0) pg/mL vs. 19.5 (15.0–28.0) pg/mL, p < 0.001). PCA analysis identified four clusters of proteins, where one cluster differed between endometriosis and controls, with strong correlations for AXIN1 and ST1A1. Plasma/serum AXIN1 is an interesting biomarker to be further evaluated in endometriosis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

AXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis

Roth

Engström

et al. 2019

IJMS

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“…IFN-γ is also expressed at elevated levels in ectopic endometrium in contrast to eutopic endometrium of patients with endometriosis; a similar situation is observed in serum as well as in peritoneal fluid of patients (97)(98)(99), which is related with an unbalanced immune activity in endometriosis. IFN-γ is involved in increasing the resistance of endometrial cells to apoptosis and to stimulate the expression of cell adhesion molecules to allow the establishment of endometriotic lesions (99).…”

Section: Alterations Of Immune Mediatorsmentioning

confidence: 62%

Regulation of Inflammation Pathways and Inflammasome by Sex Steroid Hormones in Endometriosis

et al. 2020

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Endometriosis is a gynecological disorder characterized by the growth of endometrial tissue (glands and stroma) outside the uterus, mainly in the peritoneal cavity, ovaries, and intestines. This condition shows estrogen dependency and progesterone resistance, and it has been associated with chronic inflammation, severe pain, and infertility, which negatively affect the quality of life in reproductive women. The molecular mechanisms involved in the pathogenesis of endometriosis are not completely understood; however, inflammation plays a key role in the pathophysiology of the disease, mainly by altering the function of immune cells (macrophages, natural killer, and T cells) and increasing levels of pro-inflammatory mediators in the peritoneal cavity, endometrium, and blood. These immune alterations inhibit apoptotic pathways and promote adhesion and proliferation of endometriotic cells, as well as angiogenesis and neurogenesis in endometriotic lesions. It has been demonstrated that hormonal alterations in endometriosis are related to the inflammatory unbalance in this disease. Particularly, steroid hormones (mainly estradiol) promote the expression and release of pro-inflammatory factors. Excessive inflammation in endometriosis contributes to changes of hormonal regulation by modulating sex steroid receptors expression and increasing aromatase activity. In addition, dysregulation of the inflammasome pathway, mediated by an alteration of cellular responses to steroid hormones, participates in disease progression through preventing cell death, promoting adhesion, invasion, and cell proliferation. Furthermore, inflammation is involved in endometriosis-associated infertility, which alters endometrium receptivity by impairing biochemical responses and decidualization. The purpose of this review is to present current research about the role of inflammasome in the pathogenesis of endometriosis as well as the molecular role of sex hormones in the inflammatory responses in endometriosis.

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“…It has been reported concentrations of RANTES to be elevated in ectopic endometrium and RANTES to correlate with the stage of the disease. Unfortunately, to date, there are not many studies investigating the relationship of serum RANTES with endometriosis [30,31]. In our attempt to bring to light the possible correlation between them, we found that RANTES levels were higher in women with endometriosis compared to controls but without statistically significant difference.…”

Section: Discussionmentioning

confidence: 67%

Age at Menarche and Oxidative Stress Markers in Women with Endometriosis

Augoulea

Kindis

Karopoulou

et al. 2020

SN Compr. Clin. Med.

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Endometriosis is one of the most frequent gynecological disorders defined as the existence and growth of endometrial tissue outside the uterine cavity. Aim of this study was to evaluate the level of six oxidative stress markers in the serum of patients with and without endometriosis. This study included 46 women who were undergoing laparoscopy. The participants were divided into two groups based on their laparoscopic results. Thirty-one women had visually and histopathologically confirmed endometriosis, whereas 15 did not. The serum level of ADMA (asymmetric dimethylarginine), MCP1 (monocyte chemoattractant protein 1), MMP2 (matrix metalloproteinases 2), MMP9 (matrix metalloproteinases 9), RANTES (regulated upon activation, normal T cell expressed and presumably secreted), and VEGF-A (vascular endothelial growth factor) as oxidative stress markers were measured and compared between the two groups. No significant difference in the ADMA, MCP1, MMP2, MMP9, RANTES, and VEGF-A serum levels was detected between the entometriosis patients and controls. The disease stage did not affect any of the markers' level either. Women with endometriosis had menarche at an earlier age compared to controls [11.7 (SD 1.09) vs 12.6 (SD 1.4), p = 0.04)]. These results suggest that there is no association between endometriosis and increased oxidative stress. The elevation and possible role of oxidative stress markers in the diagnosis and pathogenesis of endometriosis should be evaluated in more extended studies.

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Endometriosis-associated changes in serum levels of interferons and chemokines

Abstract: Background/aim: The aim of the study was to evaluate the serum concentration of main chemokines and interferons in patients with diagnosed endometriosis. Materials and methods:A total of 160 women were divided in two study groups (group 1 -endometriosis; group 2 -healthy women).

Cited by 20 publications

References 32 publications

AXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis

AXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis

Regulation of Inflammation Pathways and Inflammasome by Sex Steroid Hormones in Endometriosis

Age at Menarche and Oxidative Stress Markers in Women with Endometriosis

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