Age at Menarche and Oxidative Stress Markers in Women with Endometriosis

Augoulea, Areti; Kindis, A.; Karopoulou, Evaggelia; Tsoltos, Nikolaos; Kaparos, George; Tsakonas, Efstratios; Panoulis, Konstantinos

doi:10.1007/s42399-019-00214-x

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Endothelial dysfunction characterizes OS, which can promote the production of ROS and the reduction of NO. There is a relationship between NO and ADMA, the first reducing NO production and the second functioning as an endogenous inhibitor 37 . The formation of ADMA occurs through two complex events.…”

Section: Discussionmentioning

confidence: 99%

Endometrioziste oksidatif stres ve apoptozla ilişkili biyobelirteçlerin düzeyleri

ÖZBEK

Karakuş

Bakır

2023

Cukurova Medical Journal

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Purpose: In this study, the apoptosis marker M30, the oxidative stress markers malondialdehyde, (MDA) and asymmetric dimethyl arginine (ADMA) have been studied in the context of endometriosis. Materials and Methods: This prospective case-control study comprises 31 patients diagnosed with endometriosis and 31 controls. ADMA and M30 levels in blood serum were measured by the enzyme-linked immunosorbent assay (ELISA) method, and MDA levels were measured by the spectrophotometric method. In addition, some biochemical parameters and cancer antigen-125 (CA-125) levels were also measured. Results: M30 levels were statistically lower in endometriosis patients (271.5 IU/L) than in controls (371.3 IU/L). ADMA levels were higher in endometriosis patients (19.3 ng/L) compared to controls (12.7 ng/L). CA-125 levels were statistically higher in the endometriosis patients (65.1 U/mL) compared to the controls (19.0 U/mL). There was no significant difference between the two groups in MDA levels. The results regarding dyspareunia, pelvic pain, AST, and ALP were statistically significant. Conclusion: In our study, decreased M30 levels in the patient group were associated with reduced apoptosis in endometriosis. ADMA levels, elevated with the increase of oxidative stress, were higher in the patients. MDA levels, an indicator of increased oxidative stress, were also higher in the patient group. This study constitutes the first data regarding endometriosis patients' ADMA, M30, and MDA levels.

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Section: Discussionmentioning

confidence: 99%

Endometrioziste oksidatif stres ve apoptozla ilişkili biyobelirteçlerin düzeyleri

ÖZBEK

Karakuş

Bakır

2023

Cukurova Medical Journal

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“…The results of this study are following the research of Augoulea and Mukti (p-value 0.007) which showed that there was a relationship between the age of menarche and the incidence of endometriosis. 11,12 According to Sampson's theory, the incidence of endometriosis can be caused by menstrual reflux whereas women who have more menstrual opportunities will be more at risk for experiencing endometriosis. 13 Women with early age of menarche (<12 years) will be exposed to estrogen longer and the possibility of menstrual reflux will be greater, thus increasing the risk of endometriosis.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Age of Menarche and Body Mass Index (BMI) with Endometriosis Incidence at Dr. Mohammad Hoesin Palembang Period 2018 – 2020

Usman

Handayani

2022

Bioscmed

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Background. Endometriosis is the presence of endometrial glands and stroma outside the uterus. This study aims to analyze the relationship between age of menarche and body mass index (BMI) with the incidence of endometriosis. Methods. This study is an analytical observational study with a cross-sectional approach. The samples taken in this study were post-operative patients with gynecological disorders at Dr. Mohammad Hoesin General Hospital Palembang. The sample taken in this study was 62 respondents during the period 2018-2020 with a simple random sampling technique based on inclusion criteria. The research data was processed and analyzed by univariate and bivariate with Chi-square test using SPSS application. Results. Most of the respondents with endometriosis experienced at the age of menarche <12 years (91.3%) and had a non-obese BMI (73.3%). There was a significant relationship between the age of menarche and the endometriosis incidence (p=0.039). There was no statistically significant relationship between body mass index (BMI) and the endometriosis incidence (p=1,043). Conclusion. Early menarche can increase the risk of endometriosis. The majority of women with endometriosis in this study had a BMI in the non-obese category (BMI <25).

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The Relationship between Serum Levels of Oxidative Stress Biomarkers and Dysmenorrhea, Dyspareunia and Pelvic Pain in Women with Endometriosis

Amini

Shami

Chegini

2020

IJN

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Background & Aims: Endometriosis is a common disorder associated with an increased risk of cancers, especially ovarian cancer. One of the most prevalent symptoms of this disease is pelvic pain, which is the major complaint among patients during menstruation. While the pathophysiology of endometriosis and the mechanisms responsible for its complications, namely pelvic pain and infertility, are not yet well understood, it seems that oxidative stress plays an undeniable role in the pathogenesis of endometriosis. In other words, the production of large amounts of inflammatory mediators by endometriosis tissue can explain and be responsible for the onset and exacerbation of pelvic pain. There is an apparent imbalance between oxygen free radicals and antioxidants in the endometrial tissue of diagnosed women. In addition, decreased total antioxidant capacity is observed in the peritoneal fluid in women with endometriosis, which is indicative of inadequate antioxidant status. Even though a significant relationship has been reported between symptoms of pelvic pain and indicators of peritoneal oxidative stress in women with endometriosis in some studies, there are still conflicting theories about the relationship between serum biomarkers of oxidative stress and endometriosis. With this background in mind, the present study aimed to determine the relationship between serum levels of oxidative stress biomarkers and dysmenorrhea, dyspareunia, and pelvic pain in women with endometriosis who referred to Sarem Fertility & Infertility Research Center in Tehran, Iran in 2017. Materials & Methods: This was a descriptive, correlational and cross-sectional study performed on 60 women aged 15-49 years with symptoms of endometriosis. The inclusion criteria were diagnosis of endometriosis based on clinical symptoms and laparoscopy, no current pelvic inflammation disease and adenomyosis, no smoking, or alcohol and drug consumption, no chronic underlying diseases, and no psychological diseases (data were obtained through self-report). Subjects were selected by convenience sampling, and written informed consent was obtained from the participants prior to the study. Data were collected using a demographic characteristics questionnaire, fertility profile questionnaire, endometriosis symptoms checklist, research laboratory information record sheet, and visual analogue scale (VAS) for measuring pain. Following filling out the scales and questionnaires, 10 ccs of the blood sample were taken from each of the volunteers under sterile conditions in citrate tubes and stored after centrifugation at -20°C. Afterwards, blood samples were analyzed, and data analysis was carried out in SPSS version 16 using Pearson's correlation coefficient. In addition, a P-value of below 0.05 was considered statistically significant. Results: The mean age of the participants was 33.16 ± 5.41 years and the mean age of their spouses was 35.96 ± 8.62. Moreover, the subjects had a body mass index (BMI) of 25.92 ± 5.94 kg/m2, and most of them were housewives (68.3%) and ha...

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Age at Menarche and Oxidative Stress Markers in Women with Endometriosis

Cited by 3 publications

References 30 publications

Endometrioziste oksidatif stres ve apoptozla ilişkili biyobelirteçlerin düzeyleri

Endometrioziste oksidatif stres ve apoptozla ilişkili biyobelirteçlerin düzeyleri

The Relationship between Age of Menarche and Body Mass Index (BMI) with Endometriosis Incidence at Dr. Mohammad Hoesin Palembang Period 2018 – 2020

The Relationship between Serum Levels of Oxidative Stress Biomarkers and Dysmenorrhea, Dyspareunia and Pelvic Pain in Women with Endometriosis

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