Endometriosis and Infertility

Macer, Matthew; Taylor, Hugh S.

doi:10.1016/j.ogc.2012.10.002

Cited by 455 publications

(165 citation statements)

References 81 publications

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“…Surgery can improve fertility removing adhesions, cul-de-sac obliteration and endometriomas [16,17,18]. Subsequently, other infertility mechanisms such as some deficiencies in the reproductive function of the ovarian reserve, of the fallopian tubes, of the gametes or uterus that may affect the prognosis and cannot be corrected by surgical intervention may interfere [19,20]. …”

Section: Discussionmentioning

confidence: 99%

External Validation of the Endometriosis Fertility Index (EFI) for Predicting Spontaneous Pregnancy after Surgery: Further Considerations on Its Validity

Garavaglia¹,

Pagliardini²,

Tandoi

et al. 2015

Gynecol Obstet Invest

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Background/Aims: The revised American Society for Reproductive Medicine classification of endometriosis has a limited predictive value for pregnancy after surgery. A tool for predicting spontaneous pregnancy or pregnancy following assisted reproduction technology (ART) represents a clinical need. This study aimed to (i) provide an external validation of the EFI score in predicting pregnancy in infertile Italian endometriosis women; (ii) evaluate the predictive value of EFI score on ART outcome for patients who previously attempted to spontaneously conceive after surgery. Methods: In 104 women with endometriosis, EFI score was calculated based on a prospective database data. Cumulative pregnancy rates curves were calculated using Kaplan-Meier (K-M) product limit estimate and log-rank test was used to evaluate differences between EFI groups. A receiver operating characteristic (ROC) curve was plotted for EFI as a predictor of ART outcome. Results: Differences in time to non-ART pregnancy for the six EFI groups were statistically significant (log-rank, p = 1.4 × 10^-4). The area under the curve (AUC) for EFI as ART outcome predictor was 0.75 (95% CI 0.61-0.89, p = 6.2 × 10^-3), while the best cut-point for pregnancy was 5.5. Conclusion: The EFI score is a reliable scoring system to predict non-ART and ART pregnancy outcome after surgery for endometriosis.

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Section: Discussionmentioning

confidence: 99%

External Validation of the Endometriosis Fertility Index (EFI) for Predicting Spontaneous Pregnancy after Surgery: Further Considerations on Its Validity

Garavaglia¹,

Pagliardini²,

Tandoi

et al. 2015

Gynecol Obstet Invest

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“…However, so much debate has been raised on the impact of diseases on fertility. Anti-genetic growth factors, inflammatory cytokines and normal genes are among the endometriosis-related etiologic factors of infertility (9).…”

Section: Endometriosismentioning

confidence: 99%

Infertility-Related Risk Factors: A Systematic Review

Deyhoul¹,

Mohamaddoost²,

Hosseini³

2017

IJWHR

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IntroductionOxford English Dictionary defines the word "infertile" or barren as "inability to give birth or procreate. " This definition refers to the "sterilization mode rather than visualization difficulty" and presents so many clinical perspectives (1). According to the reports of the International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO), "infertility" is a couple's failure in pregnancy after 12 months of unprotected sexual intercourse and pregnancy attempts. Infertility is a global problem affecting people around the world whose cause and importance may vary according to the geographical location and socio-economic condition. According to the statistics, annually 60-80 million couples around the world suffer from infertility (2). The estimated fertility rate in Canada is 11.5% to 15.7%. One out of seven English couples suffers from fertility problems (3). The number of couples affected by infertility has increased from 42.0 million people (39.6 million people, 44.8 million people) in 1990 to 48.5 million people (45.0 million people, 52.6 million people) in 2010 (4). Ten to 12% of couples around the world are suffering from infertility in half of which, the man is infertile. The estimates show that in 35%-40% of cases, the man is infertile and in 35%-40% of cases, the woman is infertile and in 20%-30% of cases, it is related to the combination of other factors (5). Infertility occurs once pregnancies are ended up with abortion (ASR) or the delivery of a child with multiple hereditary diseases (6). Infertility diagnosis is different and may include the evaluation of sperm quality; Mormons, and analysis of imaging of uterus and fallopian tubes. According to the medical diagnosis, infertility may be treated by reproductive surgery, prescribing hormones or applying infertility technologies (2). Infertility awareness, like men and women's awareness of risk factors, is the first step in protecting pregnancy in lifestyle modification. Knowledge and awareness of fertility depends on education rather than personal fertility or motherhood and fatherhood experience. Health improving strategies started with educational interventions (3). Secondary infertility refers to a state in which pregnancy does not occur after one year (in some epidemiologic studies 2 years) of unprotected sexual intercourse despite at least one pregnancy in the past. Women with secondary infertility cannot give birth to alive child (7). Infertility may result from a wide range of abnormalities one or both of which exist. However, infertility is not much different in people and it can have a variety of causes (8). The primary and secondary causes of infertility are reviewed in this study. This study examines the following points: primary causes of infertility, such as genetic factors, hormonal disorders, genetic disorders, congenital defects or reproductive system diseases; secondary factors, including lifestyle related factors, such as obesity, diet, smoking, alcohol consumption an...

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“…The ectopic endometrial implants can be found most commonly on the ovaries, in the Pouch of Douglas, on the uterus, and in the fallopian tubes. The most widely accepted pathogenesis mechanism is a retrograde flow of menses, which would deposit still viable endometrial cells at anomalous locations; this process requires the endometrial cells to attach to the peritoneal mesothelial cells and establish vasculature to permit their proliferation (Sampson 1927, Nunley & Kitchin 1980, D'Hooghe 1997, Macer & Taylor 2012, Sundqvist et al 2012. It is clear, however, that molecular mechanisms are integral in the disease as retrograde menstruation is common (Lucidi et al 2005).…”

Section: Endometriosismentioning

confidence: 99%

Expression, activation, and role of AKT isoforms in the uterus

Fabi¹,

Asselin²

2014

Reproduction

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The three isoforms of AKT: AKT1, AKT2, and AKT3, are crucial regulators of both normal and pathological cellular processes. Each of these isoforms exhibits a high level of homology and functional redundancy with each other. However, while being highly similar and structurally homologous, a rising amount of evidence is showing that each isoform possesses specific targets as well as preferential subcellular localization. The role of AKT has been studied extensively in reproductive processes, but isoform-specific roles are yet to be fully understood. This review will focus on the role of AKT in the uterus and its function in processes related to cell death and proliferation such as embryo implantation, decidualization, endometriosis, and endometrial cancer in an isoform-centric manner. In this review, we will cover the activation of AKT in various settings, localization of isoforms in subcellular compartments, and the effect of isoform expression on cellular processes. To fully understand the dynamic molecular processes taking place in the uterus, it is crucial that we better understand the physiological role of AKT isoforms as well as their function in the emergence of diseases.Reproduction (2014) 148 R85-R95

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Endometriosis and Infertility

Cited by 455 publications

References 81 publications

External Validation of the Endometriosis Fertility Index (EFI) for Predicting Spontaneous Pregnancy after Surgery: Further Considerations on Its Validity

External Validation of the Endometriosis Fertility Index (EFI) for Predicting Spontaneous Pregnancy after Surgery: Further Considerations on Its Validity

Infertility-Related Risk Factors: A Systematic Review

Expression, activation, and role of AKT isoforms in the uterus

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