Endometriosis: alternative methods of medical treatment

Muñoz-Hernando, Leticia; Muñoz-González, José L; Marqueta-Marques, Laura; Alvarez-Conejo, Carmen; Tejerizo-García, A.; González, Gregorio López; Villegas-Muñoz, Emilia; Martin-Jimenez, Angel; Jiménez‐López, Jesús

doi:10.2147/ijwh.s78829

Cited by 12 publications

(5 citation statements)

References 75 publications

(62 reference statements)

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“…In contrast, GnRH-ant inhibit gonadotropin receptors. Elagolix improves dysmenorrhea and dyspareunia compared to placebo in a phase 2 RCT (Ezzati & Carr 2015, Munoz-Hernando et al 2015) and, comparing BMD profiles of elagolix with depot medroxyprogesterone acetate, both minimally impact BMD (Carr et al 2014, Ezzati & Carr 2015). …”

Section: Treatmentsmentioning

confidence: 99%

Endometriosis: where are we and where are we going?

Greene¹,

Lang²,

Kendziorski³

et al. 2016

Reproduction

141

107

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Endometriosis currently affects ∼5.5 million reproductive-aged women in the U.S. with symptoms such as painful periods (dysmenorrhea), chronic pelvic pain, pain with intercourse (dyspareunia), and infertility. It is defined as the presence of endometrial tissue outside the uterine cavity and is found predominately attached to sites within the peritoneal cavity. Diagnosis for endometriosis is solely made through surgery as no consistent biomarkers for disease diagnosis exist. There is no cure for endometriosis and treatments only target symptoms and not the underlying mechanism(s) of disease. The nature of individual predisposing factors or inherent defects in the endometrium, immune system, and/or peritoneal cavity of women with endometriosis remains unclear. The literature over the last 5 years (2010-2015) has advanced our critical knowledge related to hormones, hormone receptors, immune dysregulation, hormonal treatments, and the transformation of endometriosis to ovarian cancer. In this review, we cover the aforementioned topics with the goal of providing the reader an overview and related references for further study to highlight the progress made in endometriosis research, while concluding with critical areas of endometriosis research that are urgently needed.

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Section: Treatmentsmentioning

confidence: 99%

Endometriosis: where are we and where are we going?

Greene¹,

Lang²,

Kendziorski³

et al. 2016

Reproduction

141

107

View full text Add to dashboard Cite

show abstract

“…Medical management consists in reducing E2 production by administration of oral contraceptives, progestogens, GnRH agonists or androgen steroids [ 135 ]. However, hormonal treatment is only suitable for women who are not planning to conceive and there are considerable side effects.…”

Section: Organoid Systems To Model Diseases Of the Female Reproductive Tractmentioning

confidence: 99%

Organoids of the female reproductive tract

Chumduri

Turco

2021

J Mol Med

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Healthy functioning of the female reproductive tract (FRT) depends on balanced and dynamic regulation by hormones during the menstrual cycle, pregnancy and childbirth. The mucosal epithelial lining of different regions of the FRT—ovaries, fallopian tubes, uterus, cervix and vagina—facilitates the selective transport of gametes and successful transfer of the zygote to the uterus where it implants and pregnancy takes place. It also prevents pathogen entry. Recent developments in three-dimensional (3D) organoid systems from the FRT now provide crucial experimental models that recapitulate the cellular heterogeneity and physiological, anatomical and functional properties of the organ in vitro. In this review, we summarise the state of the art on organoids generated from different regions of the FRT. We discuss the potential applications of these powerful in vitro models to study normal physiology, fertility, infections, diseases, drug discovery and personalised medicine.

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“…These new therapies aim specific pathophysiologic mechanisms that have not been targeted by conventional methods. Although promising, some has not been fully tested in humans, and some are still in the early phase of clinical trials ( 24 , 25 ).…”

Section: Overview Of Endometriosis Pathogenesismentioning

confidence: 99%

New insights on the pathogenesis of endometriosis and novel non-surgical therapies

Suardika

Pemayun

2018

J Turkish German Gynecol Assoc

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Endometriosis is a disease of theories, but none has succeeded to explain the whole picture. Most widely available drugs for endometriosis aim to relieve symptoms and improve fertility. Unfortunately, many short and long-term side-effects are associated with the treatments. To overcome this problem, researchers have developed many novel therapeutic agents, including non-invasive technique. We aim to provide new insights on pathogenesis model and novel non-surgical treatments for endometriosis, including drugs already available in the market and also drugs which are still under research. Seven novel treatment modalities are recognized, namely dienogest, aromatase inhibitor (AI), gonadotrophine-releasing hormone (GnRH) antagonist, anti tumor necrosing factor (TNF)-α, selective estrogen receptor modulator (SERM), selective progesterone receptor modulator (SPRM), and high-intensity focused ultrasound (HIFU). Dienogest, AI, and GnRH antagonists are effective novel treatments with good tolerance and safety. SERM and SPRM show inconsistent results, while anti-TNF-α is still in the animal experimental stage. HIFU is a potential futuristic treatment. However, it is still a long way until this technology is truly applicable.

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Endometriosis: alternative methods of medical treatment

Cited by 12 publications

References 75 publications

Endometriosis: where are we and where are we going?

Endometriosis: where are we and where are we going?

Organoids of the female reproductive tract

New insights on the pathogenesis of endometriosis and novel non-surgical therapies

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