Endometrioma ≤3 cm in Diameter per se Does Not Affect Ovarian Reserve in Intracytoplasmic Sperm Injection Cycles

Esinler, İbrahim; Bozdağ, Gürkan; Arıkan, İlker; Demir, Bülent; Yaralı́, Hakan

doi:10.1159/000339630

Cited by 43 publications

(31 citation statements)

References 43 publications

(39 reference statements)

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“…In this context, size of the endometrioma seems to be the crucial determinant in management. Esinler et al demonstrated that the unilateral endometriomas ≤3 cm in diameter did not have a deleterious effect on ovarian reserve in ICSI cycles (29). Recently, Cocia et al observed a critical endometrioma size of 3 cm, in those with unilateral cyst, above this size, which the total numbers of follicles and retrieved oocytes were negatively affected (26).…”

Section: Discussioncontrasting

confidence: 79%

The Impact of Ovarian Endometrioma(s) on ART Outcomes: Retrospective Case Control Study

Pabuçcu

Gürsoy

Ulubaşoğlu

et al. 2016

Gynecol Obstet Reprod Med

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OBJECTIVE:To compare oocyte yield of women with intact ovarian endometrioma(s) to those without endometrioma undergoing ART. Secondary outcomes were implantation and live birth rates between the two groups. STUDY DESIGN:Retrospective case-control study was conducted to document eligible cases. A total of 165 women with intact endometrioma(s) (END) were included in the final analysis. Total of 196 cases with tubal factor infertility who underwent ART in the same time period were included as controls (CONT group). Cases and controls were matched for age, BMI and serum AMH concentrations. Ovarian stimulation characteristics and pregnancy outcomes including live birth data were documented for both groups. RESULTS:Despite similar demographic characteristics, significantly longer cycle duration and higher amounts of gonadotropin consumption was observed in END group compared to controls (p<0.001). Significantly lower number of retrieved oocytes, mature oocytes and mature oocyte fraction (%, no of retrieved/mature) were detected in END group. There was no statistically significant difference in terms of fertilization, implantation and live birth rate per started cycle among groups. Cycle cancellations were also similar. CONCLUSION:In women with intact ovarian endometrioma(s) undergoing ART, oocyte quantity, especially mature oocyte yield was hampered. However, adequate number of mature oocytes, successful fertilization and satisfactory implantation rates might be possible contributing to acceptable live births. Further randomized controlled trials of patients with different sizes of endometrioma(s) would be needed to confirm our conclusions.

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Section: Discussioncontrasting

confidence: 79%

The Impact of Ovarian Endometrioma(s) on ART Outcomes: Retrospective Case Control Study

Pabuçcu

Gürsoy

Ulubaşoğlu

et al. 2016

Gynecol Obstet Reprod Med

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“…Pooling of results from four studies Ashrafi et al, 2014;Esinler et al, 2012;Filippi et al, 2014) that reported the number of oocytes retrieved between affected ovary and intact ovary ( Figure 5B) did not show a significant difference (WMD −0.11; 95% CI −0.25 to 0.03)]. The I 2 value was 0%, indicating that heterogeneity was unlikely between the studies.…”

Section: Number Of Oocytes Retrieved Between Ovary With Endometrioma mentioning

confidence: 89%

Impact of ovarian endometrioma on ovarian responsiveness and IVF: a systematic review and meta-analysis

Yang¹,

Yang²,

et al. 2015

Reproductive BioMedicine Online

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“…A few studies have shown that women with endometriosis have decreased ovarian reserve, decreased AFC and decreased ovarian response to gonadotropin [8,9,10]. In contrast, one study done on patients undergoing intracytoplasmic sperm injection has shown no deleterious effect on ovarian reserve in women who have milder forms of endometriosis, specifically small endometriomas [11]. Accordingly, left lateralization of endometriosis might be associated with decreased number of antral follicles in the left ovary.…”

Section: Discussionmentioning

confidence: 99%

Lateralization of Ovarian Follicles

Alserri

Kuriya²,

Holzer³

et al. 2014

Gynecol Obstet Invest

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Background/Aim: To evaluate a possible lateralization of antral follicle count (AFC) based on the finding that endometriosis, if present, is more commonly found in the left hemipelvis. Methods: We evaluated the records of 6,617 baseline ultrasounds conducted at our Reproductive Center between 2007 and 2011 in a university teaching hospital setting. We included all ultrasounds with an AFC of 1 or greater and excluded those with incomplete documentation or with ovarian cyst, including endometriotic cysts (n = 909). The main outcome measure was the comparison of the number of antral follicles between the right and left ovary. Results: The number of antral follicles in the right ovary (median 18, range 15-22) was significantly higher than in the left ovary (median 16, range 13-20) among women with polycystic ovaries (PCO, AFC ≥24). Similarly, the number of antral follicles in the right ovary (median 8, range 6-10) was significantly higher than in the left ovary (median 7, range 5-9) in women with no PCO but normal ovarian reserve (AFC 10-23). Conclusions: In women with PCO and non-PCO with normal ovarian reserve, the right ovary contains a higher number of antral follicles than the left ovary.

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Endometrioma ≤3 cm in Diameter per se Does Not Affect Ovarian Reserve in Intracytoplasmic Sperm Injection Cycles

Cited by 43 publications

References 43 publications

The Impact of Ovarian Endometrioma(s) on ART Outcomes: Retrospective Case Control Study

The Impact of Ovarian Endometrioma(s) on ART Outcomes: Retrospective Case Control Study

Impact of ovarian endometrioma on ovarian responsiveness and IVF: a systematic review and meta-analysis

Lateralization of Ovarian Follicles

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