Endometrioid adenocarcinoma of the uterus with a minimal deviation invasive pattern

Abstract

Minimal deviation adenocarcinoma of endometrioid type more often develops as a result of differentiation from typical endometrioid adenocarcinoma than de novo. Due to its deceptively benign microscopic appearance, minimal deviation adenocarcinoma of endometrioid type may be overlooked and may lead to incorrect assessment of tumour depth and pathological stage. There was a tendency for tumour with a large amount of minimal deviation adenocarcinoma of endometrioid type to invade the cervix.

Fascin expression in low-grade uterine endometrioid adenocarcinoma: correlation with microcystic, elongated and fragmented (MELF)-type alteration at the deep invasive margin

“…There are well‐established and inter‐related adverse prognostic factors in endometrial neoplasia, including disease extension beyond the uterine corpus (stage II or greater), high‐grade histological subtype, increased patient age and the presence of vascular invasion 1–4 . Some studies have also suggested that the tumour growth pattern and/or the type of stromal reaction may correlate with poorer outcome 5–9 . However, although much is now known of the molecular abnormalities that occur commonly in endometrial adenocarcinoma, relatively little is known of the factors that control the process of invasion in these tumours 10 …”

Immunophenotypic features of MELF pattern invasion in endometrial adenocarcinoma: evidence for epithelial–mesenchymal transition

“…However, myoinvasion may be overestimated when intra‐endometrial tumours colonise basal glands along an irregular endometrial–myometrial junction or involve foci of adenomyosis 5 . Conversely, some frankly myoinvasive carcinomas exhibit deceptively bland growth patterns including diffuse or ‘minimal deviation’ invasion, or pushing‐type invasion where the tumour margin is relatively well circumscribed 6–9 …”

Minimal deviation adenocarcinoma of the uterine cervix: A case report

“…MDA exhibits a diffusely infiltrative growth pattern and its histologic differentiation from normal cervical glands is challenging [11]. Histologically, MDA is characterized by a hazardous arrangement of endocervical glands and their deep penetration into the cervical wall, with minor cytological atypia.…”