Minimal deviation adenocarcinoma of the uterine cervix: A case report

Ding, Dah-Ching; Chu, Tang-Yuan; Hsu, Yung‐Hsiang

doi:10.1016/j.tcmj.2014.10.001

Cited by 6 publications

(6 citation statements)

References 13 publications

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“…Radiography has limited role and identification of these glands as the reported cases of MDS cervix showed mixed solid and cystic patterns [9][10][11][12][13][14]. Guo et al [10] described multiple cervical cysts in the Magnetic Resonance Imaging (MRI) of a more conventional case of MD cervix [10].…”

Section: Discussionmentioning

confidence: 99%

Endometrial Adenocarcinoma with Pattern of Invasion Resembling Adenoma Malignum

2022

IJOR

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Endometrial adenocarcinoma with a glandular invasion pattern resembling adenoma malignum of cervix is a deceptively benign and highly differentiated form of endometrioid adenocarcinoma which can be resistant to radiation therapy and exhibit a deep invasion pattern. We report a 57-year-old female who was a biopsy-proven case of FIGO grade 2 endometrial adenocarcinoma with 4 cm cervical involvement, who underwent whole pelvic radiation therapy followed by hysterectomy. Her hysterectomy sections revealed conventional endometrioid adenocarcinoma with a deceptively bland pattern of well-spaced, branching glands with myometrial invasion up to 90%. Extensive lymphovascular space invasion was identified and cervical stroma was involved. Immunohistochemistry was consistent with an endometrial origin. The final diagnosis was endometrial adenocarcinoma with adenoma malignum pattern of invasion. It is not clear whether the gland morphology was due to radiation treatment however, the widespread and extensive invasion makes it imperative to recognize that these patients need to be vigilantly followed up. It is important to recognize this entity because these deeply invasive and benign appearing glands can be resistant to the conventional approach of radiation treatment and highlights the fact that the patient needs to be cautiously staged and accordingly treated. Keywords: Endometrial adenocarcinoma; Minimal deviation; Adenoma malignum; Uterus; Pelvic radiotherapy

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Section: Discussionmentioning

confidence: 99%

Endometrial Adenocarcinoma with Pattern of Invasion Resembling Adenoma Malignum

2022

IJOR

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“…The 2 patients were supplemented with CCRT after the surgery. The follow-up of the patient with MDA who underwent a series of medical interventions, such as total hysterectomy, bilateral salpingo-oophorectomy, lymph node dissection, and postoperative CCRT rather than extensive hysterectomy, showed an ideal prognosis [26]. A total of 18 patients with MDA were once classified into the early stage (FIGO IB1/IB2, 88.8%) and advanced stage (FIGO III/IV, 11.1%), which indicated that despite the difficulty in diagnosing timely and precisely, the majority of the patients can be detected in their early stages [27].…”

Section: Treatment Strategiesmentioning

confidence: 99%

Clinical Diagnosis and Treatment Analysis of 16 Cases of Gastric-Type Endocervical Adenocarcinoma

Wei¹,

Zhang²,

Zhu³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Objective: Cervical cancer classification based on human papillomavirus (HPV) infection status is necessary, as the popularity of HPV vaccination is increasing. Hence, this study aimed to explore the clinicopathological features, diagnosis, treatment, and prognosis of gastric-type endocervical adenocarcinoma (GAS) in west China. Methods: We performed a retrospective analysis and follow-up of patients with GAS who were hospitalized in West China Second University Hospital, a tertiary care center in west China, between September 2019 and April 2021. Results: A total of 16 cases were pathologically diagnosed as GAS at the hospital, most of which had no specific clinical manifestations. Among the 16 cases, 3 cases were confirmed preoperatively. The occurrence of full-layer cervix stroma infiltration, lymphatic vessel infiltration, and lymph node metastasis were 87.5%, 100%, and 50%, respectively. Among all cases, 8 cases were classified as stage III according to the International Federation of Gynecology and Obstetrics 2018 Clinical Staging Standard for cervical cancer. A total of 15 patients underwent a transabdominal or laparoscopic extensive hysterectomy, and the remaining 1 patient was pathologically diagnosed with GAS after a total hysterectomy and afterward underwent bilateral oophorectomy and pelvic lymph node dissection as supplementary surgeries. The follow-up data presented the survival of the 16 patients receiving concurrent chemoradiotherapy after surgery. However, GAS recurred in 3 non-medically-controlled patients among the 16 patients in 3 to 6 months after the treatment. Conclusions: GAS is a rare but highly malignant cancer that usually results in a poor prognosis. A few reports of GAS diagnosis and treatment, especially from developing countries, are available. Hitherto clinical routine screening methods might be insufficient to fulfill the requirements of GAS diagnosis owing to the difficulties in preoperative diagnosis and the probability of misdiagnosis. To reduce the rate of misdiagnosis, repeated deep multisite biopsies, cervical curettage, cervical conization, and hysteroscopy might be helpful in suspicious GAS cases.

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“…MDA tanısında servikal sitoloji kullanışlı değildir. Literatürde servikal sitoloji uygulanmış olan 135 vakanın yalnızca 34 tanesinde (%25.1) smearde prekanseröz veya kanseröz bulgular vardı (7,(8)(9)(10). Sunduğumuz vakada da servikal sitoloji normaldi.…”

Section: Literatürdeki Ilk Yayın 5 Vakanın Sunulduğuunclassified

“…Literatürde tümör boyutu 1 cm ile 12 cm arasında bildirilmektedir (10,13). Vakamızda tümör boyutu MRI' da 12.6 cm olarak raporlanmıştır.…”

Section: Uterin Serviksin Minimal Deviasyon Adenokarsinomu (Mda) -Gülunclassified

Uterin Serviksin Minimal Deviasyon Adenokarsinomu: Vaka Sunumu

Gül¹,

Çelik²,

Çakır³

et al. 2018

GenelTipDer

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ÖzMinimal deviasyon adenokarsinom(MDA) servikal adenokarsinomların %1-3 oranında görülen bir varyantıdır.Nadir görülmesi nedeniyle standart tanısal metot ve tedavi protokolü yoktur. Uterin servikste 10-12 cm boyutunda kitlesi olan vakamızda tanı servikal biyopsi ile konamadı.Manyetik rezonans görüntülemede (MRI) MDA tanısı düşünüldü ve operasyon sonrası tanı kondu. Postoperatif olarak adjuvant kemoradyoterapi (KRT) uygulandı ve hasta 16 aylık bir süre rekürrens olmadan izlendi.Anahtar Kelimeler: Minimal deviasyon adenokarsinom, uterin serviks, radikal histerektomi AbstractMinimal deviation adenocarcinoma (MDA) is a variant of cervical adenocarcinomas seen in 1-3%. There is no standard diagnostic methods and treatment protocol because of its rarity.In our case who have a mass in diameter 10-12 centimeters in uterine cervix, the diagnosis could not be established with cervical biopsy. MDA was suspected in magnetic resonance imaging (MRI) and diagnosis was established after surgery. Adjuvant chemoradiation therapy(CRT) was administered in postoperative period and the case was followed for 16 months without recurrence.

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Minimal deviation adenocarcinoma of the uterine cervix: A case report

Cited by 6 publications

References 13 publications

Endometrial Adenocarcinoma with Pattern of Invasion Resembling Adenoma Malignum

Endometrial Adenocarcinoma with Pattern of Invasion Resembling Adenoma Malignum

Clinical Diagnosis and Treatment Analysis of 16 Cases of Gastric-Type Endocervical Adenocarcinoma

Uterin Serviksin Minimal Deviasyon Adenokarsinomu: Vaka Sunumu

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