Endometrial thickness: a predictor of implantation in ovum recipients?

Abdalla, Hossam; Brooks, Amber; Johnson, Mark R.; Kirkland, A.; Thomas, Alison; Studd, John

doi:10.1093/oxfordjournals.humrep.a138509

Cited by 147 publications

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“…The previous reports evaluating the association between endometrial thickness and pregnancy outcome in oocyte donation cycles used either cleavage stage embryo transfer or a mixture of cleavage and blastocyst stage transfer; therefore, they did not maximally control the embryo factor. [5,7,12,[28][29][30]. Clearly our results should be interpreted with caution due to our small sample size.…”

Section: Discussionmentioning

confidence: 99%

Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles

Barker

Boehnlein

Kovács

et al. 2009

J Assist Reprod Genet

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Purpose To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes. Methods Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated. Donors underwent ovarian hyperstimulation using rFSH and GnRH-antagonist. Recipients were synchronized to donors using GnRH-agonist downregulation followed by fixed dose of estrogen (E2) and progesterone (P4) following hCG. Transvaginal ultrasound (US) obtained ET and EP 10-11 days after initiation of E2 and on day of embryo transfer. Primary outcome was ET and EP in pregnant and non-pregnant cycles. Stimulation and embryology data was analyzed in donors to assess differences prior to transfer.Results Fifty-nine cycles resulted in clinical pregnancy. No differences were observed in pregnant vs. non-pregnant cycles in proliferative or secretory ET and EP. Similar baseline and stimulation characteristics were found in pregnant and non-pregnant cycles. Regression analysis showed end thickness were not predictive of pregnancy outcomes. Conclusions Endometrial characteristics in recipients prior to and following progesterone were not predictive of pregnancy outcomes.

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Section: Discussionmentioning

confidence: 99%

Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles

Barker

Boehnlein

Kovács

et al. 2009

J Assist Reprod Genet

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“…Women with thin endometria have lower pregnancy rates, largely related to implantation failure 1, 2, 3, 4, 5, 6. The authors recently found high blood impedance in the uterine radial artery in patients with a thin endometrium4 and that vitamin E, L‐arginine, and sildenafil citrate treatments, which increase the blood flow of the uterine radial artery, helped to thicken the endometrium 7.…”

Section: Introductionmentioning

confidence: 99%

Thin endometrium transcriptome analysis reveals a potential mechanism of implantation failure

Maekawa

Tanaka

Mihara

et al. 2017

Reprod Medicine & Biology

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AimAlthough a thin endometrium has been well recognized as a critical factor in implantation failure, little information is available regarding the molecular mechanisms. The present study investigated these mechanisms by using genome‐wide mRNA expression analysis.MethodsThin and normal endometrial tissue was obtained from a total of six women during the mid‐luteal phase of the menstrual cycle. The transcriptomes were analyzed with a microarray. Differentially expressed genes were classified according to Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways.ResultsThe study identified 318 up‐regulated genes and 322 down‐regulated genes in the thin endometrium, compared to the control endometrium. The GO and KEGG pathway analyses indicated that the thin endometrium possessed aberrantly activated immunity and natural killer cell cytotoxicity that was accompanied by an increased number of inflammatory cytokines, such as IFN‐γ. Various genes that were related to metabolism and anti‐oxidative stress were down‐regulated in the thin endometrium.ConclusionImplantation failure in the thin endometrium appears to be associated with an aberrantly activated inflammatory environment and aberrantly decreased response to oxidative stress.

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“…The endometrial proliferation can sometimes even be less than the ideal thickness (3). It therefore prevents endometrial development and can cause a problem regarding implantation in some cases.…”

Section: Introductionmentioning

confidence: 99%

The effect of administering vaginal estrogen to clomiphene citrate stimulated cycles on endometrial thickness and pregnancy rates in unexplained infertility

Çetinkaya¹,

Kadanali²

2012

J Turkish German Gynecol Assoc

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Objective: Clomiphene citrate (CC) has some negative effects on the endometrium. We aimed to determine the effect of vaginally administered local estrogen (LE) on endometrial thickness (ET) and pregnancy rates in CC stimulated cycles. Material and Methods:This was a prospective randomized crossover study that took place in a university hospital. The patients had received CC due to unexplained infertility (UI). Two different treatment protocols were given sequentially as, either CC+LE or CC alone. Each protocol was planned for two cycles and there was a one-month wash-out period between protocols. The effects of LE on the 3 rd and 9 th day, the ovulation day (OD) and 7 th postovulation day (POD7) were investigatedResults: A total of 6 pregnancies were achieved with 3 patients from each protocol. The ET was 7.6±1.4 mm and 8.3±2.1 mm respectively and significantly different in the CC group and the CC+E2 groups on the OD (p=.039), while these values were 9.7±2.3 mm and 10.9±3.0 mm respectively and significantly different on the POD7 (p=.007). There was no significant difference between the groups for arterial PI values on the OD and POD7. The frequency of thin endometrium (<6 mm) was 15.2% and 12.2% respectively in the CC group and the CC+E2 group on the OD (p=.628) and 5.1% and 1.2% respectively on the POD7 (p=.182). Conclusion:Adding vaginal LE to CC stimulated cycles led to a significant increase in ET on the OD and POD7. However, this difference in thickness was not reflected in the pregnancy rates in this study.

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Endometrial thickness: a predictor of implantation in ovum recipients?

Cited by 147 publications

References 0 publications

Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles

Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles

Thin endometrium transcriptome analysis reveals a potential mechanism of implantation failure

The effect of administering vaginal estrogen to clomiphene citrate stimulated cycles on endometrial thickness and pregnancy rates in unexplained infertility

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