Endometrial stromal sarcoma: Where only rarity prevails over obvious presentation

Abstract

Introduction: Endometrial stromal sarcoma (Ess) is a rare malignancy arising from the endometrial stroma. the majority (90%) of patients present with abnormal uterine bleeding (AUb) followed by mass per abdomen and pelvic pain. However, rarity of this tumor limits the clinician to consider it even as a differential diagnosis despite of having its typical symptoms and only diagnosed by biopsy as a surprise. On analysis of age of presentation, clinical findings and various diagnostic modalities, endometrial stromal sarcoma (Ess) mimics other disorders such as leiomyoma, leiomyosarcoma and endometrial polyp. the diagnostic dilemma continues even on gross and microscopic features of Ess and above mentioned disorders. the role of immunomarkers like cD10, desmin, h-caldesmon, etc. has evolved for specific diagnosis. case report: A 60-year-old female was presented with a complaint of postmenopausal bleeding underwent hysterectomy with a provisional diagnosis of submucous myoma and histopathological examination revealed this as endometrial stromal sarcoma. conclusion: Endometrial stromal sarcoma is a rare

Low-grade endometrial stromal sarcoma in a postmenopausal woman with third-degree uterovaginal prolapse: A rare case with review of the literature

“…ESS has an indolent course and even many years after diagnosis recurrent disease can occur. [ 1 5 ] According to mitosis and degree of invasion, it is classified into three groups, that is, endometrial stromal nodule, low-grade ESS, and high-grade stromal sarcoma. [ 6 ] Low-grade ESS shows <10 mitoses per 10 HPF whereas a high-grade ESS shows more than 10 mitotic figures per 10 HPF.…”

“…[ 9 ] Long-term follow-up is essential in these tumors have a tendency of late recurrence and distant metastasis. [ 1 ]…”

“…According to the literature, incidence is approximately 0.2% of all uterine malignancies and approximately 10% of all uterine sarcomas. [ 1 ] It can arise from smooth muscle, connective tissue, or endometrial stroma. [ 2 3 ] ESS usually occurs in the younger age group with mean age ranging between 45 and 55 years.…”

“…ESS is commonly associated with various chromosomal aberrations, of which deletion of chromosome 7p is most common. [ 1 ] It can occur in patients with polycystic ovarian syndrome and those who are exposed to drugs such as tamoxifen or unopposed estrogen. [ 2 ] We, herein, report a case of a postmenopausal female who presented with something coming out per vagina.…”