Endometrial Stromal Sarcoma of the Vulva Arising in Extraovarian Endometriosis: A Case Report and Literature Review

Irvin, William P.; Pelkey, Timothy J.; Rice, Laurel W.; Andersen, Willie A.

doi:10.1006/gyno.1998.5142

Cited by 62 publications

(52 citation statements)

References 7 publications

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“…The malignant transformation of patients with ovarian endometriosis has been reported approximately 0.7-1.0% [1]. On the other hand, the development of cancer from adenomyosis is a relatively rare occurrence.…”

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confidence: 99%

Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report

Shin

Cho

Sung

et al. 2011

Korean J Obstet Gynecol

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The incidence of cancer from adenomyosis is rare. Previously, only two cases of clear cell adenocarcinoma (CCA) arising from adenomyosis have been reported in English literature. Here, we report a case of CCA arising from adenomyosis. A 52-year-old postmenopausal Korean woman presented with complaints of vaginal bleeding and back pain. Endometrial biopsy revealed endometrial polyp with atrophic change and transvaginal ultrasonography showed myomas with cystic change. Magnetic resonance imaging revealed a cystic degenerative mass consistent with leiomyoma in the posterior portion of uterus body. And the serum level of CA-125 was 17.7 U/mL. Hysterectomy revealed a yellow-ten solid mass in the myometrium that was diagnosed as CCA arising from adenomyosis. The tumor was mainly located in the myometrium and transition between adenomyosis and CCA along with endometrial stromal cell was identifi ed. Malignant tumor arising from adenomyosis could be considered as a differential diagnosis when the patient with adenomyosis and intact endometrial surface complained of vaginal bleeding.

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confidence: 99%

Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report

Shin

Cho

Sung

et al. 2011

Korean J Obstet Gynecol

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“…Endometriosis-associated tumors that involve the female pelvic cavity, i.e., the peritoneum, ovary and fallopian tubes are a diverse group of disorders that range in biological behavior from benign to malignant. Approximately 1.0% of women with endometriosis have lesions that undergo malignant transformation (19,67). Anatomically, lesions are divided into gonadal (80%) or extragonadal (20%) lesions (17,67).…”

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confidence: 99%

“…Approximately 1.0% of women with endometriosis have lesions that undergo malignant transformation (19,67). Anatomically, lesions are divided into gonadal (80%) or extragonadal (20%) lesions (17,67).…”

Section: Discussionmentioning

confidence: 99%

Identification of multiple pathways involved in the malignant transformation of endometriosis (Review)

et al. 2012

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Abstract. The association between endometriosis and malignant transformation has often been described in the medical literature. A search was conducted between 1966 and 2010 through the English language literature (online Medline PubMed database) using the keywords endometriosis combined with malignant transformation. The search revealed an increase in reports describing endometriosis and malignancy. Approximately 1.0% of women with endometriosis have lesions that undergo malignant transformation. The malignant processes that are associated with endometriosis may be classified into three groups: i) epithelial ovarian cancers (endometrioid adenocarcinoma and clear cell carcinoma), ii) other Müllerian-type tumors, including Müllerian-type mucinous borderline tumor and serous borderline tumor and iii) sarcomas such as adenosarcoma and endometrial stromal sarcoma in the female pelvic cavity. Persistent oxidative stress induced by endometriosis-dependent hemorrhage may be associated with carcinogenesis. In conclusion, the malignant transformation of endometriosis has multiple pathways of development and may share a common pathogenic mechanism; iron-induced oxidative stress derived from repeated hemorrhage.

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“…The rectovaginal septum, colon, vagina, and pelvic peritoneum represented the majority of extragonadal sites. Irvin et al 7 also reviewed 222 reported cases of malignancy arising in endometriosis, and reported that the ovary was most frequently involved, accounting for 169 cases (76%), and extragonadal tumors were 53 (24%). This concords with the frequency of endometriosis according to location.…”

Section: Discussionmentioning

confidence: 99%

A case of clear cell carcinoma arising from the endometriosis of the paraovarian cyst

Lee

Kim

et al. 2009

J Gynecol Oncol

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Endometrial Stromal Sarcoma of the Vulva Arising in Extraovarian Endometriosis: A Case Report and Literature Review

Cited by 62 publications

References 7 publications

Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report

Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report

Identification of multiple pathways involved in the malignant transformation of endometriosis (Review)

A case of clear cell carcinoma arising from the endometriosis of the paraovarian cyst

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