Endometrial Scratch Injury Induces Higher Pregnancy Rate for Women With Unexplained Infertility Undergoing IUI With Ovarian Stimulation: A Randomized Controlled Trial

Abstract

The ESI significantly improves the outcome of IUI in women with unexplained infertility especially when conducted 1 month prior to IUI.

Hysteroscopic‐guided local endometrial injury does not improve natural cycle pregnancy rate in women with unexplained infertility: Randomized controlled trial

“…Despite the short observation period in the present study, the cumulative PR in the intervention group (16.7%) was high compared with the no intervention group (11.7%), although it did not reach statistical significance. Compared with the literature, however, the present overall cumulative PR is relatively low. This could be explained by the fact that we are concerned mainly with the role of LEI alone.…”

“…Also, one first trimester miscarriage was reported in the control group. This is in agreement with other studies …”

“…studied the effect of LEI during the pre‐ovulatory days, also using pipelle catheter in 114 women; they found a significantly higher clinical PR compared with the control group . Further, recent studies reported that LEI significantly improves outcome of intrauterine insemination (IUI) in women with UI . Clearly, the results of these different studies on the same issue are not in agreement because they have been performed on heterogeneous patient groups, using different techniques, and for variable follow‐up periods.…”

“…Clearly, the results of these different studies on the same issue are not in agreement because they have been performed on heterogeneous patient groups, using different techniques, and for variable follow‐up periods. It was noted that neither number, day of the menstrual cycle nor site of LEI affect outcome …”

“…Given that impairment of endometrial receptivity may be a potential cause of subfertility in women diagnosed with UI, LEI may help some women with UI. Some studies reported an apparently beneficial effect in women undergoing intrauterine insemination (IUI) . Studies on the effect of LEI in women with UI conceiving spontaneously with no fertility treatment are scarce, however, and the present data are inconclusive.…”