Endometrial receptivity and pregnancy rates are higher after 7 days of progesterone in medicated FET cycles

Abstract

Varying the cost of P support, the sensitivity analysis demonstrated that P support was cost-effective as long as P costs < $569.31/week ($3415.86 for six weeks). Varying the cost of GND-IUI, the sensitivity analysis demonstrated that P luteal support was cost-effective as long as the cost of the GND-IUI cycle is R $1215. P support was costeffective across the published 95% CI for live birth increase, ranging from $220 to $6664 cost savings per live birth. CONCLUSIONS: Daily vaginal P supplementation after GND-IUI improves live birth rates and effectively reduces the overall treatment cost per live birth. These findings persisted in the analyses of vaginal P inserts and P gel as well as in all sensitivity analyses of live birth rates and the costs of GND-IUI and P support. Given the significantly higher birth rates with P supplementation and the present findings demonstrating cost-effectiveness, P luteal support should be recommended for all GND-IUI cycles.

Serum Progesterone Level in Agonist and Antagonist Protocols on the Day of Human Chorionic Gonadotropin Triggering in Prediction of Intracytoplasmic Sperm Injection Outcome

“…Endometrial receptivity is driven by time of progesterone exposure after sufficient exposure to estrogen. The time period at which the endometrium is ready to receive and support the trophoblast is called 'window of implantation', and it is limited in time [2] .…”

BMP7 coordinates endometrial epithelial cell receptivity for blastocyst implantation through the endoglin pathway in cell lines and a mouse model

“…The reaction is complex and the receptive endometrium or uterus are closely associated with the stimulated/competent/implanting blastocysts ( 2 ). The receptive endometrium and stimulated blastocysts simultaneous function to achieve blastocyst implantation, leading to pregnancy ( 3 ).…”