Serum Progesterone Level in Agonist and Antagonist Protocols on the Day of Human Chorionic Gonadotropin Triggering in Prediction of Intracytoplasmic Sperm Injection Outcome

Abstract

Background: The potential association of serum progesterone on the day of human chorionic gonadotropin administration with the outcome of intracytoplasmic sperm injection [ICSI] cycles has been one of the major controversies in the endocrinology of ovarian stimulation. Aim of the work: This study was conducted to estimate the net effect of progesterone elevation on the day of human chorionic gonadotrophin [hCG] on pregnancy outcome in women undergoing fresh embryo transfer in control ovarian stimulation using long agonist and antagonist protocols. Patients and Methods: This is a prospective study included a total of 177 patients who were indicated for ICSI. The included cases were divided into three groups according to progesterone level at the day of hCG. Both progesterone and E2 were estimated at the day of triggering. Results: Serum progesterone levels did not differ between cases who got pregnancy and who did not (p=0.435). Estrogen/Progesterone ratio was not significantly different between pregnant and non-pregnant females (p= 0.842). Conclusion: Progesterone level on the day of hCG administration does not have any effect on ICSI outcome.

Effect of High Progesterone Level on Day of Human Chrionic Gonadotropin Triggering on Pregnancy Rate in Frozen Embryo Transfer

“…Although GnRH analogues are frequently used in COS for IVF/ICSI cycles, an elevation in blood P4 levels is frequently noticed near the follicular phase's end. For a number of years, the clinical effect of premature progestrone rise has been extremely contentious, a study's showing that there is no connection between P4 levels and rates of conception (9) , whereas some have noticed a negative impact on cycle results (10,11) .…”