Endometrial polyps affect uterine receptivity

Rackow, Beth W.; Jorgensen, Eugéne C.; Taylor, Hugh S.

doi:10.1016/j.fertnstert.2010.12.034

Cited by 125 publications

(78 citation statements)

References 33 publications

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“…EPs are benign localized glandular and stromal overgrowth that represent as sessile or pedunculated lesion, may be seen single or multiple and varies in size from millimetres to centimetre (2,3,17). Based on population study, its incidence varies between 7.8% to 34.9% (18,19).…”

Section: Discussionmentioning

confidence: 99%

“…It is being thought that severe military conflicts in Africa shorten the expected lifetime for more than 2 years. In general, WHO had calculated that 269 thousand people had died in 1999 due to the effect of wars and that loss of 8.44 million healthy years of life had occurred (2,3). Wars negatively affect the provision of health services.…”

Section: War and Women's Healthmentioning

confidence: 99%

“…Moreover, the wars cause the migration of qualified health employees, and thus the health services hitches. Assessments made indicate that the effect of destruction in the infrastructure of health continues for 5-10 years even after the finalization of conflicts (3). Due to resource requirements in the restructuring investments after war, the share allocated to health has decreased (1).…”

Section: War and Women's Healthmentioning

confidence: 99%

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Histologic Features and Differential Diagnosis of Endometrial Polyps; An Update and Review

Tabrizi¹

2016

IJWHR

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IntroductionAmong the endometrial lesions, endometrial polyps (EPs) are commonly seen in the premenopausal and postmenpuasal age group and are found in 25% of endometrial specimens performed for abnormal uterine bleeding (1). EPs are generally considered as local hyperplasitic lesions of endometrial stroma which covered by epithelium. These lesions are seen single or multiple, sessile or pedunculated and the size range differs from millimetres to centimetres. In 10% of cases they mimic endocervical polyp due to prolapsus from external os (2,3). In a case of sufficient clinical, hysteroscopic and imaging information, the histologic diagnosis is usually straightforward. From clinical and prognostic standpoint, it should be emphasized that rarely these lesion may harbour premalignant and malignant lesions particularly in older age group. Therefore careful histologic examination for rule out of raised malignant lesions should be considered. In the other hand in rare cases these lesions may show metastatic involvement particularly from lobular breast carcinoma. Prevalence of these lesions in association with clinical presentation and histologic features will be presented and differential diagnosis with special emphasis on rule out of malignant lesions will be discussed. PrevalenceIn the 2402 office hysteroscopy performed on women with mean age of 39.4 years old for several indications, the prevalence of EP was 27.2% (4). Based on used diagnostic method and study group the mentioned rate varies between 6% to 32% and this rate increases with age (5-7). In another large study carried out on 686 Danish women in range of 20-79 years of old who accepted to be examined by both transvaginal sonography and saline contrast sonohysterography, the prevalence of EP was 7.8% (5). In this study the EPs were rare (0.9%) between young women and in women older than 30 years the prevalence was 9.2%. EPs are rarely found in OCP user whereas in the women who were on hormone replacement therapy the prevalence was much higher (2.1% vs. 25%) (5). Respect to hormones as an etiologic factor, high frequency of endometrial hyperplasia was found in the non-polyploid region of endometrium in premenopausal and postmenopausal women (8). Clinical PresentationThe usual clinical presentations of EPs may include menorrhagia, intermenstrual bleeding, postmenopausal bleeding and infertility. However the majority of patients may be asymptomatic and the prevalence could be similar in symptomatic and asymptomatic women (5). These findings indicates that there is no consistent relationship between abnormal uterine bleeding and existence of EPs and why hysteroscopic resection of EPs does not always result in relief of symptoms (9). A pathologist should be alert that in the most cases of protruded EPs, the usual clinical diagnosis will be endocervical polyp by the gynaecologist. Regard to tamoxifen, EPs are the most common pathology that could be seen in these patients. In these patients the prevalence of AbstractAmong the endometrial lesions, endometrial poly...

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Section: Discussionmentioning

confidence: 99%

Section: War and Women's Healthmentioning

confidence: 99%

Section: War and Women's Healthmentioning

confidence: 99%

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Histologic Features and Differential Diagnosis of Endometrial Polyps; An Update and Review

Tabrizi¹

2016

IJWHR

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“…This begs the question, could alterations in HOX gene expression in the endometrium of humans explain implantation and maintenance of pregnancy problems seen in humans affected by Müllerian anomalies? Rackow et al [118,119] have demonstrated that in the case of both submucosal uterine fibroids and endometrial polyps, both acquired structural abnormalities of the uterine cavity known to adversely affect reproductive outcome, that HOX gene expression is globally decreased in the uterus of affected individuals compared to controls. These significant findings indicate an ongoing role for HOX gene expression in the normal physiological changes of the adult.…”

Section: Reproductive Outcomes and A Possible Role For Gene Therapy Imentioning

confidence: 99%

Genetic Syndromes and Genes Involved in the Development of the Female Reproductive Tract: A Possible Role for Gene Therapy

Owen¹,

JH²

2013

J Genet Syndr Gene Ther

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Müllerian and vaginal anomalies are congenital malformations of the female reproductive tract resulting from alterations in the normal developmental pathway of the uterus, cervix, fallopian tubes, and vagina. The most common of the Müllerian anomalies affect the uterus and may adversely impact reproductive outcomes highlighting the importance of gaining understanding of the genetic mechanisms that govern normal and abnormal development of the female reproductive tract. Modern molecular genetics with study of knock out animal models as well as several genetic syndromes featuring abnormalities of the female reproductive tract have identified candidate genes significant to this developmental pathway. Further emphasizing the importance of understanding female reproductive tract development, recent evidence has demonstrated expression of embryologically significant genes in the endometrium of adult mice and humans. This recent work suggests that these genes not only play a role in the proper structural development of the female reproductive tract but also may persist in adults to regulate proper function of the endometrium of the uterus. As endometrial function is critical for successful implantation and pregnancy maintenance, these recent data suggest a target for gene therapy. Future research will be needed to determine if gene therapy may improve reproductive outcomes for patients with demonstrated deficient endometrial expression related to abnormal gene expression.

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“…Endometrial polyps occur when the endometrium is hypertrophic, due to oestrogen stimulation (1). A diagnosis is based on sonographic, hysteroscopic or hysterosonographic findings, when a polyp is spotted in the cavum uteri (2).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Glycodelin Levels Before and After Hysteroscopic Polypectomy in Infertile Patients

Sorak

Dević

2018

Serbian Journal of Experimental and Clinical Research

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Glycodelin (or placental protein 14) is a glycoprotein located in the glandular and thin epithelium of the endometrium. It is considered an important factor in the implantation process, and its traces can be found in elevated concentrations in the uterine fl ushing obtained at the time of implantation, while in the prolif ANALYSIS OF GLYCODELIN LEVELS BEFORE AND AFTER HYSTEROSCOPIC POLYPECTOMY IN INFERTILE PATIENTS

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Endometrial polyps affect uterine receptivity

Cited by 125 publications

References 33 publications

Histologic Features and Differential Diagnosis of Endometrial Polyps; An Update and Review

Histologic Features and Differential Diagnosis of Endometrial Polyps; An Update and Review

Genetic Syndromes and Genes Involved in the Development of the Female Reproductive Tract: A Possible Role for Gene Therapy

Analysis of Glycodelin Levels Before and After Hysteroscopic Polypectomy in Infertile Patients

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