Analysis of Glycodelin Levels Before and After Hysteroscopic Polypectomy in Infertile Patients

Sorak, Marija; Dević, Ana

doi:10.1515/sjecr-2017-0001

Cited by 2 publications

(4 citation statements)

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“…They were diagnosed by 2D transvaginal ultrasound examinations conducted in the first stage of the cycle, by hysterosonographic examinations, or during hysteroscopy itself. After the intervention, all the patients were followed up for one month by taking the samples of peripheral venous blood and determining the levels of the same cytokines [17]. An ultrasound check-up was also performed.…”

Section: Methodsmentioning

confidence: 99%

The effect of hysteroscopic polypectomy on the concentrations of tumour necrosis factor-α in uterine flushings and serum in infertile women

et al. 2020

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Introduction/Objective The aim of this paper is to present changes of tumor necrosis factor-α (TNF-α) levels in uterine flushings and serum of infertile female patients before and after hysteroscopic polypectomy. Methods A total of 82 infertile female patients were included in the study. The patients were divided into two groups. The first group was the experimental group and comprised 56 infertile women with endometrial polyps, whereas the second group was the control group of 26 infertile women who were not diagnosed with endometrial polyps. Results The results of this research primarily suggest that TNF-α concentrations obtained from uterine flushings and serum of infertile patients diagnosed with endometrial polyps differed before and after a surgical procedure. In the control group of patients, there was no significant difference observed regarding TNF-α concentrations in serum and uterine flushings of women without endometrial polyps. A comparison between these two groups revealed differences in TNF-α concentrations in both venous blood and uterine flushings. These differences were considered statistically significant. Conclusion Endometrial polyps are one of the causes of higher TNF-α levels in both uterine flushings and serum.

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Section: Methodsmentioning

confidence: 99%

The effect of hysteroscopic polypectomy on the concentrations of tumour necrosis factor-α in uterine flushings and serum in infertile women

et al. 2020

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“…The appropriate mouse monoclonal antibodies (Ab17247, monoclonal 001-13, provided by Abcam) were used in the appropriate attenuation (1:200) dissolved in PBS (22). Tissue sections were rinsed in PBS, and appropriate commercial detection kits were used for antigen visualization (4,23,24).The reparations were covered with glycerol and a cover slip. Immunohistochemical staining was performed, with control for quality and specificity of staining, in keeping with the UK NEQAS (UK National External Quality Assessment Scheme for Immunocytochemistry) standards, and with the use of positive and negative controls (20).…”

Section: Immunohistochemical Stainingmentioning

confidence: 99%

“…The results obtained were compared to those of other authors available in literature (27). Conclusions were made on the basis of the results obtained (4,22). For values that had a normal distribution, we used the Student's t test and Student's paired t test, and for other distributions nonparametric Mann-Whitney and Wilcoxon test is used.…”

Section: Statistical Data Processingmentioning

confidence: 99%

“…Endometrial polyps are thickenings of the uterine mucosa consisting of endometrial glands, stroma and blood vessels (2). A polyp is formed as a focal proliferation of the endometrial basal layer, while thickened blood vessels can be found in the base of the polyp (3,4). The rate of recurrence of endometrial polyps in the overall population is around 24%.…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Analysis of the Expression of the Glycodelin Cytokine in Endometrial Tissue and the Endometrial Polyp, Before and After Hysteroscopy, in Infertile Female Patients

Dević

Sorak

et al. 2021

Serbian Journal of Experimental and Clinical Research

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An endometrial polyp is most commonly a benign, localized proliferation of the glands and the endometrial stroma, covered with epithelium and protruding above the level of the mucosa. These polyps are most often diagnosed during investigation into the causes of irregular menstrual bleeding or infertility. It is produced in the highest concentration during the secretory phase of the endometrial cycle. The level of glycodelin reaches its peak 12 days after ovulation. The aim of this paper was to determine the changes in the immunohistochemical expression of glycodelin at the level of the endometrium and in the tissue of the polyp, before and after hysteroscopic polypectomy, in infertile female patients with an endometrial polyp, and in the endometrial tissue of female patients without an endometrial polyp. The study included 82 infertile female patients. The infertile patients were divided into two groups. The first was the experimental group which included 56 infertile female patients who had an endometrial polyp. The second group was the control group, composed of 26 infertile female patients who did not have an endometrial polyp. The results obtained primarily indicate the existence of changes in the immunohistochemical expression of the cytokine glycodelin in the female patients from both the experimental and the control group, not only prior to but also after hysteroscopy. A larger number of patients who have an endometrial polyp show a lack of glycodelin expression, more pronouncedly so in the bioptate of the endometrium than in the endometrial polyp.

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Analysis of Glycodelin Levels Before and After Hysteroscopic Polypectomy in Infertile Patients

Cited by 2 publications

References 20 publications

The effect of hysteroscopic polypectomy on the concentrations of tumour necrosis factor-α in uterine flushings and serum in infertile women

The effect of hysteroscopic polypectomy on the concentrations of tumour necrosis factor-α in uterine flushings and serum in infertile women

Immunohistochemical Analysis of the Expression of the Glycodelin Cytokine in Endometrial Tissue and the Endometrial Polyp, Before and After Hysteroscopy, in Infertile Female Patients

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