Endometrial markers of uterine receptivity utilizing the donor oocyte model

Damario, Mark A; Lesnick, Timothy G.; Lessey, Bruce A.; Kowalik, Ania; Mandelin, Erik; Seppälä, Markku; Rosenwaks, Zev

doi:10.1093/humrep/16.9.1893

Cited by 62 publications

(30 citation statements)

References 32 publications

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“…Glycodelin is localised on the pinopodes, but it is also secreted from luminal epithelial glands regardless of pinopode formation (72). Temporal associations have been found between glycodelin and other markers of endometrial receptivity, such as progestrone receptor B (PRB; inverse correlation), leukaemia inhibitory factor receptor (72), avb3 integrin (vitronectin receptor) (73) and MUC-1 (74), the major cell surface mucin. During implantation, the human blastocyst increases endometrial antiadhesive MUC-1 protein during the apposition phase, whereas it induces paracrine cleavage in MUC-1 at the implantation site (75).…”

Section: Endometrial Receptivity and Implantationmentioning

confidence: 99%

“…In regards to endometrial receptivity following controlled ovarian hyperstimulation (COH), glandular/-stromal dyssynchrony is common on cycle day 21-23 histology, accelerated maturation being more common in the stroma than in the glands (73). Due to variations in treatment modalities and study designs, results on glycodelin serum levels as predictors of implantation have given mixed results (38, 76).…”

Section: Endometrial Receptivity and Implantationmentioning

confidence: 99%

See 1 more Smart Citation

Glycodelin in reproductive endocrinology and hormone-related cancer

Seppälä¹,

Koistinen²,

Koistinen

et al. 2009

European Journal of Endocrinology

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Glycodelin is an endocrine-regulated glycoprotein that has significant effects on immune cells, apoptosis, reproduction, cell adhesion, differentiation and cancer. In reproduction, glycodelin contributes to capacitation and immunoprotection of spermatozoa, and it modulates sperm-oocyte binding, acrosome reaction and implantation. In endocrine-related cancer, the differentiation inducing effects of glycodelin are accompanied by growth restriction of malignant cells, decreased expression of oncogenes, increased expression of tumour suppressor genes and morphological reversion of the malignant phenotype. This review features these properties and clinical connections, highlighting the role of glycosylation in biological actions.

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Section: Endometrial Receptivity and Implantationmentioning

confidence: 99%

Section: Endometrial Receptivity and Implantationmentioning

confidence: 99%

Glycodelin in reproductive endocrinology and hormone-related cancer

Seppälä¹,

Koistinen²,

Koistinen

et al. 2009

European Journal of Endocrinology

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“…Endometrium from patients with endometriosis or Microarray studies of endometrium unexplained infertility, when compared to endometrium from women with a past history of fertility, shows a number of changes in the transcriptome, which may be of functional significance . However, there is substantial overlap in expression levels of these markers between subfertile patients and normal controls and so clinically, the predictive value of any one of these molecular markers is low (Damario et al 2001). Two studies have compared gene expression in women with a past history of fertility on days LHC2 (prereceptive) and LHC7 (receptive).…”

Section: The Use Of Arrays To Identify Genes Involved In Endometrial mentioning

confidence: 99%

Large-scale gene expression studies of the endometrium: what have we learnt?

Sherwin¹,

Catalano²,

Sharkey³

2006

Reproduction

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The endometrium is a dynamic tissue that undergoes coordinated changes under the influence of steroid hormones. This results in proliferation and differentiation culminating in a receptive state, followed by menstruation and endometrial repair. These functions involve complex interactions between the epithelium, stroma and leucocytes in the endometrium. Understanding the underlying causes of endometrial disorders, such as infertility, endometriosis and heavy menstrual bleeding, therefore represents a considerable challenge. Recently developed techniques, such as differential display and DNA microarrays permit the abundance of thousands of mRNA transcripts within cells or tissues to be measured simultaneously. This provides a new approach to understanding the complex interactions that underlie both healthy and disease states. Responses of the endometrium to hormones or drugs can be studied and the response of the system as an integrated whole can be assessed. Comparisons of endometrium from healthy women and those with endometrial dysfunction have advanced our understanding of key areas of endometrial physiology, including infertility, receptivity, endometriosis and cancer. Using this approach, novel genes controlling specific endometrial functions like receptivity have been identified for functional testing. This paper will review the impact of these techniques for transcript profiling on our understanding of selected areas of endometrial biology and discuss the potential applications in future.

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“…Moreover, there was no significant B allele additive effect on ovulation rate in a Landrade/Large White population studied by Linville et al (2001). These results produced by various authors suggest that the effect of the estrogen receptor gene could be associated to percentage fetal survival and/or may be also associated to the success of embryo implantation (Damario et al, 2001). …”

Section: Discussionmentioning

confidence: 89%

Association of the estrogen receptor gene Pvu II restriction polymorphism with expected progeny differences for reproductive and performance traits in swine herds in Brazil

et al. 2006

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Estrogen has an important function in swine reproduction and growth. A Pvu II restriction enzyme polymorphism has been proven to be an important genetic variation in the estrogen receptor gene (ESR) and may be considered as a candidate gene for use in pig production but there is no data regarding the prevalence of this polymorphism in the Brazilian pig population. We used DNA samples from the following three purebred pig breeds: Large White (336 females and 26 males), Landrace (304 females and 27 males) and Pietrain (125 females and 11 males). The ESR genotyping was performed using PCR-RFLP. For each breed, genotypes for the ESR gene were compared independently for expected progeny differences (EPD) in litter size (LS), average daily weight gain (DWG) (g/day) and back fat thickness (BT) as measured in mm by ultrasound. In the Large White breed, but not the other breeds, the ESR genotype was significantly (p < 0.05) associated to LS, DWG and BT. Large Whites genotyped as AA or AB had higher EPD values for the LS and BT traits compared to BB Large Whites, while AA Large Whites had higher DWG EPD values than BB Large Whites. Our results for the Large White population showed that the A allele has a beneficial effect on LS, DWG and BT expected progeny differences.

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Endometrial markers of uterine receptivity utilizing the donor oocyte model

Cited by 62 publications

References 32 publications

Glycodelin in reproductive endocrinology and hormone-related cancer

Glycodelin in reproductive endocrinology and hormone-related cancer

Large-scale gene expression studies of the endometrium: what have we learnt?

Association of the estrogen receptor gene Pvu II restriction polymorphism with expected progeny differences for reproductive and performance traits in swine herds in Brazil

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