Endometrial Leukemia Inhibitory Factor (LIF) as a Possible Cause of Unexplained Infertility and Multiple Failures of Implantation

Hambartsoumian, E

doi:10.1111/j.1600-0897.1998.tb00345.x

Cited by 204 publications

(122 citation statements)

References 31 publications

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“…Recent studies further demonstrate that uterine conditional deletion of Stat3 also induces implantation failure (Lee et al, 2013, Pawar et al, 2013, Sun et al, 2013. In the human, a low level of LIF is associated with unexplained recurrent abortion and infertility (Hambartsoumian, 1998, Piccinni et al, 1998. These findings collectively indicate that the LIF-LIRFR/gp130-Stat3 axis is essential for normal embryo implantation.…”

Section: Cytokinesmentioning

confidence: 63%

Molecular determinants of uterine receptivity

Tu¹,

Hao²,

Zhang³

et al. 2014

Int. J. Dev. Biol.

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Uterine receptivity is defined as a limited period when the uterine environment is conducive to blastocyst acceptance and implantation. Any disturbance of this early pregnancy event will compromise pregnancy success. In this review, we first briefly summarize uterine morphological coordination for the attainment of receptivity, then focus on elucidating the molecular complexity in establishing uterine receptivity and hence embryo implantation. A better understanding of the molecular basis governing uterine receptivity will help to improve the outcome of natural pregnancy and pregnancy conceived via assisted reproductive techniques.

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Section: Cytokinesmentioning

confidence: 63%

Molecular determinants of uterine receptivity

Tu¹,

Hao²,

Zhang³

et al. 2014

Int. J. Dev. Biol.

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“…45 The presence of a sufficient amount of human LIF protein in the uterus at the time of implantation has been suggested as an essential condition for implantation. 46 It is possible that p53 plays a similar role in human fecundity through regulation of uterine LIF levels at the implantation stage. Indeed, a study from Carolyn Coulum's group reported that the P72 allele of the p53 gene, which has an altered p53 transcriptional activity compared to the R72, is associated with the recurrent implantation failure in an IVF clinic.…”

mentioning

confidence: 99%

p53: A new player in reproduction

Feng²,

Atwal³

et al. 2008

Cell Cycle

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“…DOI: 10.3109/19396368.2013.862316 A reduced endometrial receptivity has been correlated with an increasing number of women with unexplained infertility [Strowitzki et al 2006]. Previous studies have shown diminished expression of integrin [Lessey et al 1995], selectin [Foulk et al 2007], and LIF [Laird et al 1997;Hambartsoumian 1998] amongst unexplained infertile women. In a previous study, it is documented that endometrial LIF levels following ovulation induction with CC were comparable to spontaneous cycles in women with unexplained infertility [Kuscu et al 2002].…”

Section: Discussionmentioning

confidence: 99%

Endometrial receptivity markers in infertile women stimulated with letrozole compared with clomiphene citrate and natural cycles

Ganesh

Chauhan²,

Chakravarty

et al. 2013

Systems Biology in Reproductive Medicine

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Though various advantages associated with the use of letrozole as an ovulation inducing drug are documented, there is inadequate information regarding its effect on endometrial receptivity. Expression of endometrial receptivity markers including a v b 3 integrin, L-selectin, LIF, and pinopods during the implantation window in infertile women stimulated with letrozole or clomiphene citrate (CC), and spontaneous cycles is investigated. A total of 36 women were included in the study out of which 16 women were diagnosed with primary unexplained infertility and the other 20 women with severe oligoasthenozoospermic/azoospermic male partners. Both groups were sub-divided into three groups; women stimulated with letrozole, or with CC, and the third group was allowed to ovulate spontaneously (natural cycles). Women having natural cycles and not given any drug were considered as controls. Once ovulation was confirmed by ultrasonography, endometrial samples were collected on the seventh day post-ovulation and analyzed. In women with unexplained infertility treated with letrozole and CC, epithelial and stromal expression of a v b 3 integrin, L-selectin, leukemia inhibitory factor (LIF), and pinopod formation was found to be significantly higher as compared to controls. Expression of these receptivity markers was found to be comparable amongst the letrozole, CC, and control groups in women with severe oligoasthenozoospermic/azoospermic male partners. Cell cycle analysis showed similar cell cycle phase fractions on comparing the CC and the letrozole groups. Stimulation with letrozole and CC appears to enhance endometrial receptivity in women with unexplained infertility. However, letrozole and CC did not have any significant effect on the endometrial receptivity markers of women with severe oligoasthenozoospermic/azoospermic male partners.

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Endometrial Leukemia Inhibitory Factor (LIF) as a Possible Cause of Unexplained Infertility and Multiple Failures of Implantation

Cited by 204 publications

References 31 publications

Molecular determinants of uterine receptivity

Molecular determinants of uterine receptivity

p53: A new player in reproduction

Endometrial receptivity markers in infertile women stimulated with letrozole compared with clomiphene citrate and natural cycles

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