Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization

Serafini, P.; Rocha, A.M.; Osório, C. Toledo; Silva, Ismael da; Motta, E.L.A.; Baracat, Edmund C.

doi:10.1016/j.ijgo.2007.12.005

Cited by 19 publications

(19 citation statements)

References 26 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been shown that women with higher endometrial LIF levels during midsecretory phase are more likely to get pregnant than are women with lower LIF levels. 75 Deceased uterine LIF levels are often associated with decreased fertility in humans; women with unexplained infertility have lower LIF levels compared with fertile women. 76,77 Furthermore, high endometrium LIF levels are associated with a successful implantation after an IVF cycle in IVF patients.…”

Section: Monographsmentioning

confidence: 99%

Regulation of Fertility by the p53 Family Members

Zheng

Wang

2011

Genes & Cancer

View full text Add to dashboard Cite

The p53 family members, which consist of 3 transcription factors-p53, p63, and p73-are conserved during evolution. The p53 family proteins are involved in many important cellular functions, including tumor suppression (p53 and p73), the development of epithelial cell layers (p63), and the development of central nervous system and immune system (p73). Studies on p53-like proteins in low organisms have demonstrated that their primordial functions are to maintain the genomic integrity of germ cells and ensure faithful development and reproduction. In vertebrates, the p53 family proteins retain these functions in reproduction and at the same time have developed additional important functions in reproduction, such as the regulation of embryonic implantation (p53). p53 regulates embryonic implantation through transcriptional regulation of leukemia inhibitory factor (LIF). p63, in particular TAp63, is a main regulator to protect the fidelity of female germ cells during meiotic arrest. p73, in particular TAp73, regulates the ovary function and the quality of oocytes. Loss of p53, p63, or p73 genes in female mice leads to a significant decrease in fertility. These functions of the p53 family proteins in reproduction provide a plausible explanation for positive evolutionary selection observed in a group of single nucleotide polymorphisms and haplotypes in the p53 family genes. A better understanding of the functions of the p53 family proteins in reproduction may lead to new strategies for fertility treatment.

show abstract

Section: Monographsmentioning

confidence: 99%

Regulation of Fertility by the p53 Family Members

Zheng

Wang

2011

Genes & Cancer

View full text Add to dashboard Cite

show abstract

“…[ [25][26][27] TGF-β During the menstrual cycle, the expression of the isoform transforming growth factor-beta (TGF-β) varies, being more intense in glandular epithelium during the late-secretory phase. Moreover, TGF-β may play a role in human implantation by promotion of adhesion of trophoblast cells to the ECM in in vitro assay.…”

Section: Il-6mentioning

confidence: 99%

Platelet-rich plasma or blood-derived products to improve endometrial receptivity?

Bös-Mikich

Ferreira

Oliveira³

et al. 2019

J Assist Reprod Genet

View full text Add to dashboard Cite

The use of platelet-rich plasma (PRP) to improve endometrial receptivity is gaining increasing attention in assisted reproduction technologies. The authors report that autologous PRP intrauterine administration improves pregnancy and birth rates, particularly in cases of patients presenting poor endometrial growth. Different groups of scientists proposed a similar approach years ago using whole blood-derived products also to improve endometrial receptivity. The important role played by cytokines and growth factors during embryo implantation has been well-known for a long time. These signaling molecules are present and released by blood cells during physiological, normal endometrial growth and implantation. Similar blood mediators are released from platelet granules upon a blood vessel injury. Methods described for PRP preparation for intrauterine administration are not precise, and they seem to be similar to those used to prepare peripheral blood-derived products. Thus, it is possible that when preparing PRP from whole blood, the final plasma product used as BPRP^contains platelets in addition to the important cytokines and growth factors released by the peripheral blood mononuclear cells present in the whole blood. Precise knowledge of the identity, concentration, and effects of the individual blood factors, their origin, whether platelets or blood mononuclear cells, will greatly contribute to improve and to make results obtained in fertility treatments more repeatable.

show abstract

“…Повышенная экспрессия мРНк LIf обнаружена в популяции лимфоцитов децидуальной оболочки, которые накапливаются в большом количестве в месте имплантации; это позволяет предполагать, что LIf опосредует взаимодействие между материнскими децидуальными лимфоцитами и цитотрофобластом. Serafini et al продемонстрировали, что у женщин с бесплодием и выраженной экспрессией LIf в середине лютеиновой фазы шансы на достижение беременности в 6 раз выше по сравнению с пациентками со сниженной экспрессией LIf [30]. Более того, у пациенток с СПя нарушена экспрессия ряда генов в период «окна имплантации» [31].…”

unclassified

Endometrium and polycystic ovary syndrome

et al. 2018

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Patients with PCOS present with several endometrial abnormalities possibly explaining some of the adverse endometrium-related outcomes in these women. PCOS is inconsistently associated adverse pregnancy outcomes and an increased risk of endometrial cancer. The purpose of this review is to systematize the available data on endometrial dysfunction associated with PCOS. (For citation: Yakovlev PP, Kogan IYu. Endometrium and polycystic ovary syndrome. Journal of Obstetrics and Women’s Diseases. 2018;67(4):60-66. doi: 10.17816/JOWD67460-66).

show abstract

Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization

Abstract: Endometrial expression of LIF during the luteal phase can be used as a predictor of IVF success.

Cited by 19 publications

References 26 publications

Regulation of Fertility by the p53 Family Members

Regulation of Fertility by the p53 Family Members

Platelet-rich plasma or blood-derived products to improve endometrial receptivity?

Endometrium and polycystic ovary syndrome

Contact Info

Product

Resources

About