Endometrium and polycystic ovary syndrome

The polycystic ovary syndrome (POS) is a common hormonal disorder in women all over the world; it is characterized not only by reproductive disturbances but by endocrine and metabolic as well. Women with POS are subjected to an increased risk for the development of type 2 diabetes mellitus, metabolic syndrome and sterility. This article presents information on POS problems, its history. The main etiological factors predisposing to the development of polycystic ovaries syndrome are highlighted. Besides, actual data on pathogenetic theories of POS development are presented.

show abstract

The role of endometrial factor in recurrent implantation failure (literature review)

Podzolkova

Shamugia

Varlakova

2023

Medicinskij alfavit

View full text Add to dashboard Cite

Over the past 30 years, assisted reproductive technologies (ART) have developed signifcantly, despite this, not every woman gets a long-awaited pregnancy on her frst attempt at in vitro fertilization (IVF). Not only the quality of gametes is important for successful embryo implantation, but also the readiness of the endometrium for nidation. Dysbiosis of the uterine microbiome can interfere with the necessary physiological changes of the endometrium in the dynamics of the menstrual cycle, reducing the success rate of ART programs. Endometrial structure mismatch with embryonic development leads to an implantation window shift, which together with uterine microbiome changes is one of the causes of recurrent implantation failures (RIF). In recent years, to improve the effectiveness of ART programs, increasing attention has been paid to the study and preparation of the endometrium for embryo transfer. High-throughput sequencing and analysis of the variable regions of the 16S ribosomal RNA gene is a rapid and affordable diagnostic tool that allows identifcation of culturable and non-culturable microorganisms. The debate about the need for treatment of chronic endometritis (CE), becomes more relevant when considering the prevalence of CE (21% among RIFs). The use of matrix RNA sequencing from endometrial tissue sample cells (RNA-seq) as an additional diagnostic method for RIF causes can help in personalized embryo transfer. This can increase the chances of successful implantation. RIF of endometrial origin is a complex problem of modern reproductive medicine. Currently, there is no consensus on the role of the listed endometrial factors of RIF. Receptive endometrium is one of the determinants of successful implantation. However published studies are insuffcient to reasonably recommend the wide application of methods for diagnosis and treatment of such endometrial factors as uterine microbiome changes and implantation window displacement.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Endometrium and polycystic ovary syndrome

Cited by 3 publications

References 58 publications

Endometrial condition in patients with polycystic ovary syndrome

Endometrial condition in patients with polycystic ovary syndrome

Polycystic ovaries: problematics, etiology, pathogenesis (literary review)

The role of endometrial factor in recurrent implantation failure (literature review)

Contact Info

Product

Resources

About