Endometrial effects of letrozole and clomiphene citrate in women with polycystic ovary syndrome using spiral artery Doppler

Baruah, Jinee; Roy, Kallol Kumar; Rahman, Syed Monajatur; Kumar, Sunesh; Sharma, Jai Bhagwan; Karmakar, Debjyoti

doi:10.1007/s00404-008-0714-4

Cited by 54 publications

(53 citation statements)

References 19 publications

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“…[27,34,35,36] Two of the studies showed no differences in pregnancy rates. [35,36] However Atay V et al, when utilizing 2.5mg of letrozole versus 100mg of clomiphene for 5 days in the early follicular phase, found fewer mature follicles (1.2 versus 2.4) but higher pregnancy rates with letrozole use (22% versus 9%).…”

Section: Chronic Anovulationmentioning

confidence: 93%

“…[26] In addition, uterine artery Doppler indices are favorable in women undergoing letrozole treatment. [27] Optimal dose or length of treatment by letrozole is yet to be defined.…”

Section: World Journal Of Pharmaceutical Researchmentioning

confidence: 99%

“…[34] Baruah and his group found no differences in number of mature follicles (1.62 versus 1.63) for letrozole at 2.5 or 5mg on days 3-7 of the cycle, but a higher pregnancy rate at 19% versus 12.5%. [27] In women who failed to ovulate with lower doses of clomiphene citrate or letrozole, for the clomiphene citrate group. [25] The addition of metformin to these two drugs may alter the relative value of these medications.…”

Section: Chronic Anovulationmentioning

confidence: 99%

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Glimpse on Splendid Aromatase Inhibitor – Letrozole - A Pragmatic Review

Neerjesh¹

2017

WJPR

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Letrozole is the third-generation aromatase inhibitor (AI) most commonly used in assisted reproduction. It brings ovulation by inhibiting estrogen production; the consequent hypoestrogenic state enhances GnRH release and pituitary follicle-stimulating hormone (FSH) synthesis. Letrozole has fewer side effects, and a shorter halflife than clomiphene citrate, and no demonstrable effect upon the receptivity of the endometrium. It is effective in treating women with chronic anovulation, unexplained infertility and diminished ovarian reserve. Its safety is superior to clomiphene citrate. Utilizing bioequivalent doses, letrozole pregnancy rates are equal or superior to clomiphene citrate. Several studies reveal situations where it is more efficacious than gonadotropin treatment. A conclusion established was letrozole is as effective as other methods of ovulation induction. Further randomizedcontrolled studies are warranted to define more clearly the efficacy and safety of letrozole in human reproduction.

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Section: Chronic Anovulationmentioning

confidence: 93%

“…[26] In addition, uterine artery Doppler indices are favorable in women undergoing letrozole treatment. [27] Optimal dose or length of treatment by letrozole is yet to be defined.…”

Section: World Journal Of Pharmaceutical Researchmentioning

confidence: 99%

Section: Chronic Anovulationmentioning

confidence: 99%

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Glimpse on Splendid Aromatase Inhibitor – Letrozole - A Pragmatic Review

Neerjesh¹

2017

WJPR

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“…4,5 In a number of studies, symptoms such as changes in vascularization of ovaries with PCOS, increase of blood flow in the affected stroma as well as reduction in Resistance Index and Pulsatility Index (PI) have been reported in the involved ovary. 6 In some studies, uterine artery RI was higher and ovarian artery RI was lower than. 7,8 In these patients, medications such as clomiphene citrate, letrozole and metformin are used to stimulate ovulation and treat infertility.…”

Section: Researchmentioning

confidence: 99%

“…AMJ 2018;11 (6) Polycystic ovarian morphology in sonography. The presence of 12 or more follicles with a diameter less than 10mm, and increasing ovarian volume over 10cc in grey scale sonography is diagnostic for this syndrome.…”

Section: Researchmentioning

confidence: 99%

The combination of letrozole and metformin has a better therapeutic effect on uterine and ovarian arteries in PCOS patients

Farshchian¹,

Nezhad²,

Kamangar³

2018

AMJ

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BackgroundPolycystic ovary syndrome (PCOS) is the most prevalence endocrine disorder in the reproductive age of women. In these patients, medications such as clomiphene citrate, letrozole and metformin are used to induce ovulation and overcome infertility. AimsThis study was done for comparing the findings of Color Doppler sonography of the uterine and ovarian arteries in women with PCOS under treatment of two drug groups of letrozole-metformin and clomiphene-metformin. MethodsIntervention-applied study was performed on 108 women with secondary infertility due to PCOS in Imam Reza Hospital of Kermanshah in 2016. Women were divided in two groups of 54 people, for investigating the effect of letrozole-metformin and clomiphene-metformin on ovarian and uterine arteries. ResultsBlood flow in the uterus and ovaries significantly increased after treatment with letrozole-metformin and clomiphenemetformin (P<0.05). However, the effect of letrozolemetformin was significantly higher than that of clomiphenemetformin on uterine and ovarian arteries Resistance Index (RI) (P<0.05). ConclusionLetrozole-metformin as well as clomiphene-metformin have a significant effect on blood flow in the uterus and ovaries. The group which received letrozole-metformin had a better response in this regard. Key WordsInfertility, Resistance Index (RI), Polycystic Ovary Syndrome (PCOS) What this study adds:1. What is known about this subject? PCOD is one of the most common fertility disorders in women of reproductive age with several treatment methods. What new information is offered in this study?The reduction of RI in the uterine and ovarian arteries was greater in letrozole-metformin group compared to clomiphene citrate-metformin. Treatment with letrozolemetformin is recommended. What are the implications for research, policy, or practice?Since polycystic ovary can cause infertility, treatment or control of this disease can help infertile couples in fertility.

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