Endometrial carcinoma in patients under 40 years of age: insights from the Bulgarian Cancer Registry

Yordanov, Angel; Kostov, Stoyan; Kornovski, Yavor; Slavchev, Stanislav; Ivanova, Yonka; Calleja‐Agius, Jean; Fiore, Riccardo Di; Suleiman, Sherif; Piciu, Andra; Hasan, Ihsan; Vasileva-Slaveva, Mariela

doi:10.5603/gp.a2022.0106

Cited by 1 publication

(2 citation statements)

References 24 publications

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“…These studies indicate that young patients are frequently diagnosed with stage I cancers and rarely exhibit lymph node or distant metastasis. The most frequent pathologic type for young patients is endometrioid carcinoma [ 4 ]. Also, tumors in young patients are typically highly differentiated and have less DMI [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it is necessary to determine if VBT can provide effective disease control like EBRT while minimizing radiation toxicity in this population. Meanwhile, survival in young patients has not significantly improved in the last 30 years [ 4 ]. This suggests the need for further exploration of treatment modalities for this patient group.…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and radiation therapy modality of younger patients with early-stage endometrial cancer, a multicenter study in China’s real world

Zhang,

Wang,

Liu

et al. 2024

BMC Cancer

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Background Endometrial cancer is a prevalent gynecologic malignancy found in postmenopausal women. However, in the last two decades, the incidence of early-stage has doubled in women under 40 years old. This study aimed to investigate the clinical and pathological characteristics and adjuvant therapeutic modalities of both young and not -young patients with early-stage endometrial cancer in China’s real world. Methods This retrospective study analyzed patients with early-stage endometrial cancer at 13 medical institutions in China from 1999 to 2015. The patients were divided into two groups: young (≤ 45 years old) and non-young (> 45 years old). Statistical comparisons were conducted between the two groups for clinical characteristics, pathological features, and survival. The study also identified factors that affect local recurrence-free survival (LRFS) using Cox proportional risk regression analysis. Propensity score matching (1:1) was used to compare the effects of local control between vaginal brachytherapy (VBT) alone and pelvic external beam radiotherapy (EBRT) ± VBT. Results The study involved 1,280 patients, 150 of whom were 45 years old or younger. The young group exhibited a significantly higher proportion of stage II, low-risk, lower uterine segment infiltration (LUSI), and cervical invasion compared to the non-young group. Additionally, the young patients had significantly larger maximum tumor diameters. The young group also had a significantly higher five-year overall survival (OS) and a five-year LRFS. Age is an independent risk factor for LRFS. There was no significant difference in LRFS between young patients with intermediate- to high-risk early-stage endometrial cancer who received EBRT ± VBT and those who received VBT alone. Conclusions In the present study, young patients had better characteristics than the non-young group, while they exhibited higher levels of aggressiveness in certain aspects. The LRFS and OS outcomes were better in young patients. Age is an independent risk factor for LRFS. Additionally, VBT alone may be a suitable option for patients under 45 years of age with intermediate- to high-risk early-stage endometrial cancer, as it reduces the risk of toxic reactions and future second cancers while maintaining similar local control as EBRT.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and radiation therapy modality of younger patients with early-stage endometrial cancer, a multicenter study in China’s real world

Zhang,

Wang,

Liu

et al. 2024

BMC Cancer

View full text Add to dashboard Cite

show abstract

Endometrial carcinoma in patients under 40 years of age: insights from the Bulgarian Cancer Registry

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Ginekologia Polska" are listed in PubMed.

Cited by 1 publication

References 24 publications

Clinical characteristics and radiation therapy modality of younger patients with early-stage endometrial cancer, a multicenter study in China’s real world

Clinical characteristics and radiation therapy modality of younger patients with early-stage endometrial cancer, a multicenter study in China’s real world

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