Endometrial Carcinoma and its Precursors

Javadian, Pouya; Nezhat, Farr

doi:10.1007/978-3-030-38474-6_4

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…Hepatocellular carcinoma (HCC) is a common malignant cancer in humans, and the fourth leading cause of cancer-associated morality worldwide (1,2). Globally, from 2004 to 2017, the incidence of hepatocellular carcinoma was 1/100,000 (3), with a low overall 5-year survival rate of 18% (4). In addition to liver resection and liver transplantation, targeted therapy, immunotherapy and transarterial chemoembolization are used to treat advanced HCC (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Increased fibrillarin expression is associated with tumor progression and an unfavorable prognosis in hepatocellular carcinoma

Zhang

et al. 2020

Oncol Lett

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Hepatocellular carcinoma (HCC) is the sixth most common cancer and third most common cause of cancer-associated mortality worldwide. Hepatectomy and liver transplantation are the main treatments for early HCC. Immunotherapy and targeted therapy for advanced HCC have become increasingly popular; however, their clinical benefits are limited. Thus, identification of novel therapeutic targets for advanced HCC remains essential. Fibrillarin (FBL) is an essential nucleolar protein that catalyzes the 2′-O-methylation of ribosomal RNAs. Recently, experimental data have suggested that FBL can influence breast-cancer progression. However, the association between FBL expression and HCC remains known. In the present study, the UALCAN database was used to assess FBL mRNA expression in HCC. Immunohistochemistry analysis was performed to detect FBL protein expression in 139 patients with HCC. In addition, bioinformatic analysis was performed using the UALCAN, the Database for Annotation, Visualization and Integrated Discovery, cBioportal and TargetScan databases. Data were analyzed using Kaplan-Meier curves and the log-rank test, and a Cox proportional hazards regression model. The results demonstrated that FBL expression was significantly higher in tumor tissues compared with para-tumor tissues. Furthermore, high FBL expression was significantly associated with tumor diameter and advanced TNM stage in HCC. High FBL expression also predicted a shorter overall survival time and disease-free survival time in patients with HCC. Bioinformatics analysis demonstrated that FBL may be regulated by methylation modification. In addition, analyses of functional annotations using the Gene Ontology database indicated that FBL-related genes were predominantly enriched in DNA repair and proliferation-related cell-signaling pathways. Notably, high FBL expression signified larger tumor diameter, advanced tumor stage and a poor prognosis. Taken together, the results of the present study suggest that FBL may be a potential target for HCC treatment.

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Section: Introductionmentioning

confidence: 99%

Increased fibrillarin expression is associated with tumor progression and an unfavorable prognosis in hepatocellular carcinoma

Zhang

et al. 2020

Oncol Lett

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“…Endometrial cancer is a malignant tumor that arises from the epithelial lining of the endometrium, which is the inner layer of the uterus. It ranks second among female reproductive malignancies and is the third most common cause of death in women ( 32 , 33 ). The disease is frequently asymptomatic in the early stages, and incidental discovery during general or gynecological examination is common.…”

Section: Pathophysiology Of Chronic Pain In Gynecological Cancermentioning

confidence: 99%

Pain nursing for gynecologic cancer patients

Wu¹,

He²,

Li³

et al. 2023

Front. Oncol.

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Gynecological malignancy remains a prevalent cause of mortality among women. Chronic cancer pain, as a severe complication of malignancy and its therapies, accounts for a substantial burden of physical and psychological distress in affected patients. Accordingly, early identification, assessment, and standardized management of such pain are crucial in the prevention or delay of its progression. In the present review, we provide a comprehensive overview of the pathological factors that contribute to pain in patients with gynecological malignancy while highlighting the underlying mechanisms of pain in this population. In addition, we summarize several treatment modalities targeting pain management in gynecologic cancer patients, including surgery, radiotherapy, and chemotherapy. These interventions are crucial for tumor elimination and patient survival. Chronic cancer pain exerts a significant impact on wellbeing and quality of life for patients with gynecologic cancer. Therefore, our review emphasizes the importance of addressing this pain and its psychological sequelae and advocates for a multidisciplinary approach that encompasses nursing and psychological support. In summary, this review offers valuable insights into the pathological factors underlying pain, reviews pain management modalities, and stresses the critical role of early intervention and comprehensive care in enhancing the quality of life of these patients.

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“…Ishiwaka and RL95-2 cell invasion after ITGA7 interference with Matrigel-plated Transwell insert (Corning, Inc.). The Matrigel-plated Transwell insert (Corning, Inc.) were precoated with Matrigel (BD Bioscience) at 37˚C for 1 h. Briefly, at 48 h after transfection, 4x10 4 Ishiwaka and RL95-2 cells in serum-free medium (Gibco; Thermo Fisher Scientific, Inc.) were added into the upper Matrigel-plated Transwell insert, and the lower wells contained 600 µl corresponding complete medium [MEM (MilliporeSigma) containing 5% FBS for Ishiwaka cells or DMEM/F-12 (Gibco; Thermo Fisher Scientific, Inc.) containing 10% FBS for RL95-2 cells]. After 24 h at 37˚C, the non-migrated cells were gently removed.…”

Section: Cell Invasion Assay Transwell Assay Was Used For Analyzingmentioning

confidence: 99%

“…Endometrial cancer (EC) is a common gynecological malignancy that endangers the lives of women worldwide (1,2). Meanwhile, the incidence of EC is increasing, not only in developed countries but also in developing ones, which renders EC an enormous threat to public health (3,4). It is proposed that obesity, diabetes, polycystic ovary syndrome and Lynch syndrome are risk factors for EC; molecular abnormalities such as PI3K/AKT and Wnt/β-catenin pathway mutations are also highly associated with EC (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Effect of integrin α7 on cell proliferation, invasion, apoptosis and the PI3K/AKT pathway, and its association with clinicopathological features in endometrial cancer

et al. 2022

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Targeting integrin α7 (ITGA7) suppresses malignant progression of several types of cancer, including tongue squamous cell carcinoma, hepatocellular carcinoma and non-small cell lung cancer, while the effect of its knockdown on cell function and its association with clinicopathological features in endometrial cancer (EC) is unclear. The present study aimed to investigate this issue. ITGA7 was knocked down by short-interfering (si)RNA in Ishikawa and RL95-2 cells followed by western blotting and reverse transcription-quantitative PCR assays. Subsequently, cell proliferation, apoptosis, invasion and expression levels of PI3K, phosphorylated (p-) PI3K, AKT and p-AKT were determined using Cell Counting Kit-8, TUNEL, Transwell assays and western blotting. Moreover, ITGA7 in tumor and adjacent tissues from 50 patients with endometrial cancer was detected using immunohistochemical assay. ITGA7 expression was increased in EC cell lines (HEC-1A, RL95-2, Ishikawa and KLE) compared with telomerase-immortalized human endometrial stromal cells (THESCs). In both Ishikawa and RL95-2 cells, three ITGA7 siRNAs all demonstrated good efficiency on ITGA7 knockdown, amongst which the one with the highest efficiency was selected for the following experiments. ITGA7 knockdown reduced cell proliferation and invasion, while inducing apoptosis; moreover, it suppressed p-PI3K/PI3K and p-AKT/AKT ratios. In patients with EC, ITGA7 expression was increased in tumor tissues compared with adjacent tissues, and its lower tumor expression was associated with myometrial invasion (<1/2), non-lymphovascular invasion and decreased FIGO stage. In conclusion, ITGA7 knockdown repressed proliferation, invasion and the PI3K/AKT pathway while inducing apoptosis in EC cell lines, and its insufficiency was associated with less advanced tumor features in EC patients. These results indicated that ITGA7 may be a potential target for the treatment of EC.

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Endometrial Carcinoma and its Precursors

Cited by 9 publications

References 33 publications

Increased fibrillarin expression is associated with tumor progression and an unfavorable prognosis in hepatocellular carcinoma

Increased fibrillarin expression is associated with tumor progression and an unfavorable prognosis in hepatocellular carcinoma

Pain nursing for gynecologic cancer patients

Effect of integrin α7 on cell proliferation, invasion, apoptosis and the PI3K/AKT pathway, and its association with clinicopathological features in endometrial cancer

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