Endometrial Adenocarcinoma With Signet Ring Cells

Boyd, Clinton; Cameron, Iain C.; McCluggage, W. Glenn

doi:10.1097/pgp.0b013e3181e20c66

Cited by 20 publications

(21 citation statements)

References 14 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One was associated with concurrent intestinal metaplasia of the endocervical canal. Two cases of endometrial adenocarcinomas with signet ring cells have been reported in the literature [6] and an additional case of mucinous adenocarcinoma of the endometrium was found to have a gastric phenotype on immunohistochemistry mimicking a minimal deviation adenocarcinoma of the cervix [7]. As in this case, all were associated with more typical appearing endometrioid adenocarcinoma.…”

Section: Discussionmentioning

confidence: 60%

Endometrioid adenocarcinoma with simultaneous endocervical and intestinal-type mucinous differentiation: report of a rare phenomenon and the immunohistochemical profile

et al. 2013

View full text Add to dashboard Cite

Intestinal differentiation in the endometrium is rare with only case reports in the international literature. We describe a case of simultaneous endocervical and intestinal-type mucinous differentiation with goblet cells arising in a FIGO grade 1 endometrioid adenocarcinoma. The patient had no involvement of the myometrium, cervix, or extra-uterine sites. There were no intestinal metaplastic changes of the endocervical canal. The etiology of this change is unknown, although recent reports suggest an association with hyperestrogenism.Virtual slidesThe virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1209512176931698

show abstract

Section: Discussionmentioning

confidence: 60%

Endometrioid adenocarcinoma with simultaneous endocervical and intestinal-type mucinous differentiation: report of a rare phenomenon and the immunohistochemical profile

et al. 2013

View full text Add to dashboard Cite

show abstract

“…In our case, negativity to Vimentin and positivity to CEA proved useful in excluding primary signet-ring cell carcinoma of the endometrium an entity even rarer than PCSRCC [10-12]. …”

Section: Discussionmentioning

confidence: 92%

“…In fact, primary signet-ring cell carcinoma of the endometrium has only been observed in 4 previous cases [10-12]. …”

Section: Introductionmentioning

confidence: 99%

A new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: Immunohistochemical and molecular studies and review of the literature

Giordano¹,

Pizzi²,

Berretta³

et al. 2012

World J Surg Onc

View full text Add to dashboard Cite

BackgroundAs a rule, endocervical tumours with signet-ring cell are classed as metastatic extra-genital neoplasms. In a patient aged 45 years, we describe primary cervical signet-ring cell carcinoma (PCSRCC) characterized by prominent endometrial and myometrial involvement, simulating primary endometrial adenocarcinoma with cervical extension. In addition, a review was made of the literature to identify the clinical and pathological features of this rare malignancy.Case presentationA 45-year-old woman was referred to our Gynaecology Department due to persistent abnormal vaginal bleeding. Transvaginal ultrasonography showed slight endometrial irregularities in the whole uterine cavity suggestive of endometrial neoplasms. Pelvic magnetic resonance imaging revealed diffuse enlargement of the cervix, which had been replaced by a mass. Induration extended to the parametria and sigmoid colon fat.Histological examination of endometrial curettage and a cervical biopsy revealed a neoplasm characterized by neoplastic signet-ring cells and trabecular structures. Immunohistochemical analysis and molecular studies showed certain findings consistent with a cervical neoplasm, such as positivity to CEA, keratin 7, Ca-125 and p16 and the presence of HPV (Human Papilloma Virus) DNA 18.On examination of the hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy, the lesion replacing the cervix, endometrium and myometrium, revealed the same immunohistochemical findings observed on endometrial curettage and cervical biopsy specimens. Metastases were found in an ovarian cystic lesion and the lymph nodes.ConclusionWith this report the authors have demonstrated that the spread of cervical adenocarcinoma to the uterine corpus, although rare, may be observed, and that in this instance immunohistochemical and molecular studies can provide sufficient information for accurate diagnosis even on small biopsy specimens.

show abstract

“…Mooney et al [1] did not specify the percentage of the SRC component. We believe that the title of the paper is not accurate, so that the tumour would be defined as “endometrioid adenocarcinoma of the uterine corpus with SRCs component.” The title of the case described by Boyd et al [3] is correct. The authors described a grade I EA in an endometrial polyp, with presence of small foci of solid tumour composed of SRCs.…”

Section: Discussionmentioning

confidence: 94%

“…To the best of our knowledge primary carcinoma of the endometrium with SRCs has only been observed in four previous cases [1–3] (Table 1). In fact primary pure endometrial SRCs adenocarcinomas of the genital tract are extremely rare, while more often they may be seen admixed with other more conventional types.…”

Section: Introductionmentioning

confidence: 99%

HPV11 Positive Endometrioid Carcinoma of the Endometrium with Signet-Ring Cells: Diagnostic Criteria and Review of the Literature

Pusiol

2014

Case Reports in Pathology

View full text Add to dashboard Cite

The presence of signet-ring cells in an endometrial adenocarcinoma is extremely uncommon and it is always necessary to rule out a metastatic neoplasm. We report a FIGO grade 2 endometrial carcinoma with a signet-ring cell component found in the curettage performed to a 53-year-old woman. The neoplastic proliferation was also found in the endometrium of the radical hysterectomy with bilateral salpingo-oophorectomy and pelvic and para-aortic lymphadenectomy. The uterine neoplasm invaded less than one-half of the myometrium (FIGO stage I B). Alcian blue showed the presence of mucin in the signet-ring cells. The patient was alive and without evidence of recurrence 14 months after surgery. Polymerase chain reaction method from paraffin-embedded tissue revealed the presence of human papilloma virus type 11. We have discussed the differential diagnosis of this kind of neoplasm and we have reviewed the literature on signet-ring cell carcinoma of the endometrium.

show abstract

Endometrial Adenocarcinoma With Signet Ring Cells

Cited by 20 publications

References 14 publications

Endometrioid adenocarcinoma with simultaneous endocervical and intestinal-type mucinous differentiation: report of a rare phenomenon and the immunohistochemical profile

Endometrioid adenocarcinoma with simultaneous endocervical and intestinal-type mucinous differentiation: report of a rare phenomenon and the immunohistochemical profile

A new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: Immunohistochemical and molecular studies and review of the literature

HPV11 Positive Endometrioid Carcinoma of the Endometrium with Signet-Ring Cells: Diagnostic Criteria and Review of the Literature

Contact Info

Product

Resources

About