Endolymphatic space size in patients with Meniere’s disease and healthy controls

Ito, Taeko; Kitahara, Tadashi; Inui, Hiroshi; Miyasaka, Toshiteru; Kichikawa, Kimihiko; Ota, Ichiro; Nario, Kazuhiko; Matsumura, Yachiyo; Yamanaka, Toshiaki

doi:10.3109/00016489.2016.1169556

Cited by 46 publications

(31 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6,15 In our dataset, EH is seen in only 4.7% of the asymptomatic ears, whereas percentages of 6% and 22% have been documented in contralateral MD ears in other studies. 6,8 Even in patients with other VAIEP, a clinically relevant group, EH was demonstrated in only 7% of symptomatic ears. This finding is in line with previously published prevalence data in healthy control ears by Ito et al, 8 in which EH (vestibular or cochlear) was present in 10% of the ears.…”

Section: Discussionmentioning

confidence: 99%

“…6,8 Even in patients with other VAIEP, a clinically relevant group, EH was demonstrated in only 7% of symptomatic ears. This finding is in line with previously published prevalence data in healthy control ears by Ito et al, 8 in which EH (vestibular or cochlear) was present in 10% of the ears.…”

Section: Discussionmentioning

confidence: 99%

“…Most interesting, EH is not exclusively seen in MD but is also reported in healthy ears, monosymptomatic disease (vertigo, tinnitus, or hearing loss), and vestibular migraine. [8][9][10] Based on the potential relevance of EH in patients suspected of having MD, new diagnostic criteria have been proposed, differentiating primary hydropic ear disease (old terminology "definite MD" and "probable MD") from hydrops due to secondary causes such as labyrinthitis or congenital hearing loss. 11 Vestibular hydrops, in particular in the saccule, seems strongly correlated with MD, as demonstrated by recent MR imaging studies.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Value of Endolymphatic Hydrops and Perilymph Signal Intensity in Suspected Ménière Disease

Steekelenburg

Weijnen

Pont

et al. 2020

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE: Ménière disease is characterized by endolymphatic hydrops, whereas perilymphatic enhancement on MR imaging has been suggested to be of additional value in diagnosing Ménière disease. This study evaluates the presence of endolymphatic hydrops and perilymphatic enhancement in patients with Ménière disease and with other vertigo-associated inner ear pathology. MATERIALS AND METHODS: A 3D-FLAIR sequence 4 hours after intravenous gadolinium injection was performed to visualize the endolymph and perilymph in 220 patients suspected of having Ménière disease. Patients' ears were retrospectively categorized as having Ménière disease (probable or definite) or other vertigo-associated inner ear pathology not attributable to Ménière disease. Endolymphatic hydrops was evaluated using a visual classification system, and perilymphatic enhancement was scored both visually and quantitatively. RESULTS: Endolymphatic hydrops was present in 137 (91.9%) of the definite Ménière disease ears and in 9 (7.0%) of the ears with other vertigo-associated inner ear pathology (P , .001). The combination of endolymphatic hydrops and visually increased perilymphatic enhancement was present in 122 (81.9%) definite Ménière disease ears compared with 4 (3.1%) ears with other vertigo-associated inner ear pathology (P , .001). This combination increases the positive predictive value from 0.94 for endolymphatic hydrops and 0.91 for perilymphatic enhancement to 0.97. The addition of measured perilymphatic enhancement leads to a moderate decrease in sensitivity from 0.92 for endolymphatic hydrops to 0.86. CONCLUSIONS: The combination of perilymphatic enhancement and endolymphatic hydrops in patients suspected of having Ménière disease increases the positive predictive value in the diagnosis of definite Ménière disease. ABBREVIATIONS: EH ¼ endolymphatic hydrops; MD ¼ Ménière disease; PE ¼ perilymphatic enhancement; SIR ¼ signal intensity ratio; VAIEP ¼ vertigoassociated inner ear pathology M énière disease (MD) is characterized by attacks of vertigo, low-frequency hearing loss, and tinnitus. In the absence of a diagnostic standard, clinical diagnostic criteria were defined by the American Academy of Otolaryngology-Head and Neck Surgery and updated into a consensus of diagnostic guidelines by

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Value of Endolymphatic Hydrops and Perilymph Signal Intensity in Suspected Ménière Disease

Steekelenburg

Weijnen

Pont

et al. 2020

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…The V E ranges include all different grades of endolymphatic hydrops ± standard deviation, Bl blurriness, DS Dice score, Sc scatter, V E volume of the endolymphatic space, V T volume of the total fluid space performs more favorably and more stably in the presence of increased noise (very probable in real-world data). Current ELS MR volumetric assessment approaches remain few and involve a manual or semi-automatic segmentation [6,18,50,52]. Already a considerable improvement, these approaches require lengthy user interaction that is not suitable for use in more extensive group studies or clinical routine.…”

Section: Volt-performance and Usabilitymentioning

confidence: 99%

“…Today, the relationship between ELH and MD symptoms (for review cp [3]), as well as the specificity of ELH for MD, has come under scrutiny. The underlying reason is that different ELH patterns can be found not only in MD [4,5], but also so far in 3.3-28% of healthy ears [6,7], various inner ear [8][9][10] and central [11][12][13][14] pathologies, as well as in anatomic or vascular abnormalities affecting endolymph resorption [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

VOLT: a novel open-source pipeline for automatic segmentation of endolymphatic space in inner ear MRI

et al. 2020

View full text Add to dashboard Cite

Background Objective and volumetric quantification is a necessary step in the assessment and comparison of endolymphatic hydrops (ELH) results. Here, we introduce a novel tool for automatic volumetric segmentation of the endolymphatic space (ELS) for ELH detection in delayed intravenous gadolinium-enhanced magnetic resonance imaging of inner ear (iMRI) data. Methods The core component is a novel algorithm based on Volumetric Local Thresholding (VOLT). The study included three different data sets: a real-world data set (D1) to develop the novel ELH detection algorithm and two validating data sets, one artificial (D2) and one entirely unseen prospective real-world data set (D3). D1 included 210 inner ears of 105 patients (50 male; mean age 50.4 ± 17.1 years), and D3 included 20 inner ears of 10 patients (5 male; mean age 46.8 ± 14.4 years) with episodic vertigo attacks of different etiology. D1 and D3 did not differ significantly concerning age, gender, the grade of ELH, or data quality. As an artificial data set, D2 provided a known ground truth and consisted of an 8-bit cuboid volume using the same voxel-size and grid as real-world data with different sized cylindrical and cuboid-shaped cutouts (signal) whose grayscale values matched the real-world data set D1 (mean 68.7 ± 7.8; range 48.9-92.8). The evaluation included segmentation accuracy using the Sørensen-Dice overlap coefficient and segmentation precision by comparing the volume of the ELS. Results VOLT resulted in a high level of performance and accuracy in comparison with the respective gold standard. In the case of the artificial data set, VOLT outperformed the gold standard in higher noise levels. Data processing steps are fully automated and run without further user input in less than 60 s. ELS volume measured by automatic segmentation correlated significantly with the clinical grading of the ELS (p < 0.01). Conclusion VOLT enables an open-source reproducible, reliable, and automatic volumetric quantification of the inner ears' fluid space using MR volumetric assessment of endolymphatic hydrops. This tool constitutes an important step towards comparable and systematic big data analyses of the ELS in patients with the frequent syndrome of episodic vertigo attacks. A generic version of our three-dimensional thresholding algorithm has been made available to the scientific community via GitHub as an ImageJ-plugin.

show abstract

Endolymphatic volume in patients with meniere's disease and healthy controls: Three‐dimensional analysis with magnetic resonance imaging

Ito

Inui

Miyasaka

et al. 2019

Laryngoscope Investig Oto

View full text Add to dashboard Cite

ObjectiveRecently, 3‐Tesla magnetic resonance imaging (MRI) with intravenous gadolinium injection has been used to reveal endolymphatic hydrops (EH). In the present study, we aimed to evaluate EH in patients with Meniere's disease (MD) objectively and quantitatively, and compared the endolymphatic space (ELS) in individuals with MD and healthy controls, to gain understanding of the characteristics of MD.MethodsEighty‐two patients with unilateral MD (uMD), 16 patients with bilateral MD (bMD), and 47 healthy volunteers were enrolled. All participants underwent 3‐T MRI at 4 hours after intravenous gadolinium injection. The volumes of the total fluid space (TFS) and ELS were measured semiautomatically using our workstation, and the percentage of ELS to TFS (ELS percentage) was calculated.ResultsThe ELS percentage was 13.9 in the ears of controls, 18.2 in the contralateral ear of individuals with uMD, 26.1 in the affected ears of these individuals, and 23.0 in both ears of individuals with bMD. The ELS percentages in the affected ear of uMD and the ears of bMD individuals were significantly higher than that in the ears of control individuals (P < .01, one‐way analysis of variance (ANOVA), Tukey's test).ConclusionThe ELS is significantly larger in the affected ears of uMD and in both ears of bMD individuals. Accurate diagnosis of MD can be facilitated by using 3‐T MRI 4 hours after intravenous gadolinium injection and performing volumetric measurements of the ELS.Level of Evidence2b

show abstract

Endolymphatic space size in patients with Meniere’s disease and healthy controls

Cited by 46 publications

References 19 publications

Value of Endolymphatic Hydrops and Perilymph Signal Intensity in Suspected Ménière Disease

Value of Endolymphatic Hydrops and Perilymph Signal Intensity in Suspected Ménière Disease

VOLT: a novel open-source pipeline for automatic segmentation of endolymphatic space in inner ear MRI

Endolymphatic volume in patients with meniere's disease and healthy controls: Three‐dimensional analysis with magnetic resonance imaging

Contact Info

Product

Resources

About