Endolymphatic volume in patients with meniere's disease and healthy controls: Three‐dimensional analysis with magnetic resonance imaging

Ito, Taeko; Inui, Hiroshi; Miyasaka, Toshiteru; Shiozaki, Tomoyuki; Hasukawa, Akihito; Yamanaka, Toshiaki; Kichikawa, Kimihiko; Kitahara, Tadashi

doi:10.1002/lio2.313

Cited by 25 publications

(22 citation statements)

References 21 publications

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“…However, these 3D analyses are time intensive and impractical for routine work. Therefore, we proposed a convenient semi-quantification volume-referencing grading system according to the reported inner ear fluid volume results ( 9 , 10 ). The VR scores showed a better correlation with the MD clinical features than the Bernaerts scores described by Bernaerts et al ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

“…The radiologists were blinded to the patient's information according to an adjusted 2D volume-referencing semi-quantification grading system (VR scores, Figure 1 ). We preferred 2D semi-quantification analysis and made an adjusted criteria according to the inner ear fluid volume ( 21 ) and the normal endolymph ratio ( 10 ) described by Inui et al and Ito et al ( Table 1 ). In brief, the degree of ELH in the vestibule and cochlea was assessed by visual comparison of the relative areas of the non-enhanced endolymphatic space vs. the contrast-enhanced perilymph space in several axial planes.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, volume quantification methods of the inner ear, especially the endolymph, have been introduced. However, these methods require specific scan sequences, 3D workstations ( 8 – 10 ), or probabilistic atlas ( 11 ) that require imaging processing capabilities and therefore may be difficult to establish in a clinical setting. Relatively, clinicians prefer a 2D semi-quantitative grading system that is easily and quickly applicable without having to invest further time or resources, for example, the grading standard stated by Nakashima ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

“…The volume ratio and the semicircular canals should be taken into consideration to better represent the total ELH of inner ears. Therefore, an adjusted grading standard was used in this study, according to the literature about the volume ratio ( 10 ) to evaluate the ELH of MD patients.…”

Section: Introductionmentioning

confidence: 99%

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The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease

Zhang

Zheng

et al. 2021

Front. Neurol.

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Background: Although magnetic resonance imaging (MRI) of the membranous labyrinth and electrocochleography (ECochG) have been used to diagnose endolymphatic hydrops (ELH) in patients with Ménière's disease (MD), the relationship between imaging and ECochG is not well-documented.Objectives: This study evaluates the ELH using 3D-FLAIR MRI and extra-tympanic ECochG (ET-ECochG) and correlates the results from 3D-FLAIR MRI to those from ET-ECochG.Materials and Methods: 3D-FLAIR MRI images of 50 patients were assessed using a 2D volume-referencing grading system (VR scores, relative scores according to the known volumes of the cochlea, vestibule, and semicircular canals). Forty healthy subjects were included and compared to 51 definite MD ears of 50 patients while analyzing the ET-ECochG, which used a self-made bronze foil electrode. The amplitude ratio of the summating potential (SP) to the action potential (AP) (SP/AP) and the area ratio of SP to AP (Asp/Aap) were collected. Relative ELH grade scores were then correlated to ET-ECochG (SP/AP, Asp/Aap).Results: The VR scores showed a better correlation (r = 0.88) with the pure tone average (PTA), disease duration, and vertigo frequency of MD than the Bernaerts scores (grading the cochlea and vestibule separately) (r = 0.22). The SP/AP and Asp/Aap of the unilateral MD patients were statistically comparable to those measured in contralateral ears and the results between the definite MD ears with healthy ears were statistically comparable (p < 0.05). In a ROC analysis Asp/Aap (area under curve, AUC 0.98) significantly (p = 0.01) outperformed SP/AP (AUC 0.91). The total score of ELH, vestibular ELH, and cochlear ELH were also correlated with SP/AP and Asp/Aap. The strongest correlation was found between the Asp/Aap and cochlear ELH (r = 0.60).Conclusion: The 2D volume-referencing grading system was more meaningful than the Bernaerts scores. A correlation was found between ELH revealed by 3D-FLAIR MRI and the SP/AP of ET-ECochG in evaluating definite MD patients. The Asp/Aap appeared a more sensitive and reliable parameter than SP/AP for diagnosing the ELH of the membranous labyrinth.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease

Zhang

Zheng

et al. 2021

Front. Neurol.

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“…Following this, patients received additional examinations, including vestibular-evoked potential tests, the video head impulse test, electrocochleography and MRI to show presence of endolymphatic hydrops. 4 A diagnosis was reached according to the classification of vestibular disorders from the Barany Society [5][6][7][8][9][10][11] and Japan Society for Equilibrium Research in 1987 and 2017 (in Japanese). In addition, orthostatic dysregulation was diagnosed according to the criteria defined by Joseph et al, 12 and psychogenic dizziness was diagnosed according to the criteria by Dieterich et al 13 and by consultation with specialised psychiatrists.…”

Section: Diagnostic Procedures By Neurotologists At Our Centrementioning

confidence: 99%

Differences between primary care physicians and specialised neurotologists in the diagnosis of dizziness and vertigo in Japan

et al. 2020

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Objective Vertigo and dizziness are frequent symptoms in patients at out-patient services. An accurate diagnosis for vertigo or dizziness is essential for symptom relief; however, it is often challenging. This study aimed to identify differences in diagnoses between primary-care physicians and specialised neurotologists. Method In total, 217 patients were enrolled. To compare diagnoses, data was collected from the reference letters of primary-care physicians, medical questionnaires completed by patients and medical records. Results In total, 62.2 per cent and 29.5 per cent of the patients were referred by otorhinolaryngologists and internists, respectively. The cause of vertigo or dizziness and diagnosis was missing in 47.0 per cent of the reference letters. In addition, 67.3 per cent of the diagnoses by previous physicians differed from those reported by specialised neurotologists. Conclusion To ensure patient satisfaction and high quality of life, an accurate diagnosis for vertigo or dizziness is required; therefore, methods or materials to improve the diagnostic accuracy are needed.

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An Update on the Epidemiology and Clinicodemographic Features of Meniere's Disease

De Ravin,

Quimby,

Bartellas

et al. 2024

The Laryngoscope

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ObjectiveTo characterize the estimated prevalence and clinicodemographic features of Ménière's disease (MD) using current diagnostic criteria.MethodsA cross‐sectional study was undertaken at our tertiary academic referral center. All patients seen in Otolaryngology clinic with ICD‐10 diagnoses of MD, from January 1, 2013 to July 31, 2022 were identified. Chart review was undertaken to determine the estimated prevalence of MD meeting AAO‐HNS diagnostic criteria. Clinicodemographic features were evaluated against a comparator group without MD seen in our health system.ResultsOf 806 ICD‐10 diagnoses of MD, we identified 480 MD cases meeting diagnostic criteria (168 definite). Mean age at presentation for MD cases was 49 years. Forty‐seven percent of cases were male. A significantly higher proportion of MD cases than comparators were white (76% vs. 66%, p < 0.001). Mean time since MD symptom onset was 6.7 years, with a mean attack duration of 4.6 h; 7.5% of MD cases reported a positive family history, and 7% had bilateral disease. The odds of reporting migraine were significantly greater among MD patients than comparators (OR 1.74 [1.26–2.42]); the odds of having autoimmune conditions were lower (OR 0.45 [0.28–0.74]); and the odds of reporting allergies were no different (OR 0.96 [0.74–1.25]) versus comparator patients after controlling for demographic characteristics.ConclusionsAmong MD diagnoses, there is a low estimated prevalence of MD meeting diagnostic criteria, and an even lower prevalence of definite MD. Compared to a comparator group of patients seen for any disorder, patients with MD are more likely to be white, male, and have a history of migraine.Level of Evidence4 Laryngoscope, 2024

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Endolymphatic volume in patients with meniere's disease and healthy controls: Three‐dimensional analysis with magnetic resonance imaging

Cited by 25 publications

References 21 publications

The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease

The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease

Differences between primary care physicians and specialised neurotologists in the diagnosis of dizziness and vertigo in Japan

An Update on the Epidemiology and Clinicodemographic Features of Meniere's Disease

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