Endogenous opioid peptides and the control of the menstrual cycle

Ferin, Michel; Wiele, Raymond Vande

doi:10.1016/0028-2243(84)90059-5

Cited by 49 publications

(27 citation statements)

References 21 publications

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“…The infl uence of opioids and their antagonists on the hypothalamic-pituitary-gonadal (HPG) axis have been performed in laboratory animals (1). In female animals, exogenous opioids and endogenous opioid peptides caused a signifi cant decrease in LH pulse frequency (14), whereas naloxone promoted an increase in the LH surge compared with saline controls (15).However, in very young (10 to 30 d-old) male rats, naloxone failed to increase serum LH (16) and did not induce pubertal changes. It seems that the concentration of testosterone in males has a positive preliminary effect on the action of opioid antagonist on the secretion of LH and as we showed in this study, in Morphine and Morphine + Naltrexone treated animals that the concentration of testosterone were lower than the control group, Naltrexone failed to increase the serum level of LH.…”

Section: Discussionmentioning

confidence: 99%

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Moradi¹,

Mahmoodi²,

Raoofi³

et al. 2015

BLL

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Abstract:Background: Knowledge about harmful effects of morphine on hormone secretion seems to be necessary. The aim of the present study was to evaluate the effect of pentoxifylline on side effects derived by morphine on hypophyso-gonadal hormones of male rats. Methods: 32 male rats were divided into the 4 groups of OSS: control (received 40 g Sucrose/l drinking water and intraperitoneal injection of 1 l/kg normal saline), OMS: morphine group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and intraperitoneal injection of 1 l/kg normal saline), NMS: morphine+naltrexane group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and IP injection dose of 10 mg/kg/ml/day Naltrexane) and PMS: morphine + pentoxifylline group (received 0.4 mg/dl + 40 g Sucrose/l in drinking water and IP injection dose of 12 mg/kg/ml/day Pentoxifylline) for 56 days, respectively. Results: Serum levels of testosterone, LH, FSH hormones were measured. Pentoxifylline increased serum levels of testosterone, LH, FSH hormones compared to control, morphine and morphine-naltrexane groups. Conclusion: Pentoxifylline has a signifi cant effi cacy for increasing serum levels of sexual hormones. Considering that Pentoxifylline is safe and cheap, with easy application, we suggest for the usage of this drug for improving semen parameter's quality before performing ART for the treatment of morphine addicts (Fig. 1, Ref. 31). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Moradi¹,

Mahmoodi²,

Raoofi³

et al. 2015

BLL

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“…In rodents, the synthesis of β-endorphin is linked to the transcription of POMC mRNA [19]. β-endorphin-containing neurons inhibit GnRH neuronal activity during the progestin-dominated luteal phase of the menstrual cycle [20]. Stress-sensitive animals cease ovulation immediately upon exposure to stress, which could potentially involve rapid activation of POMC neurons and release of β-endorphin.…”

Section: Introductionmentioning

confidence: 99%

Corticotropin-Releasing Hormone and Pro-Opiomelanocortin Gene Expression in Female Monkeys with Differences in Sensitivity to Stress

Centeno

Sanchez

Reddy³

et al. 2007

Neuroendocrinology

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Background/Aims: The expressions of corticotropin-releasing hormone (CRH) and pro-opiomelanocortin (POMC) were assessed in brain tissue collected from nonstressed female cynomolgus monkeys previously categorized as highly stress resilient (HSR), medium stress resilient (MSR), or stress sensitive (SS) with respect to stress-induced anovulation. Methods: In situ hybridization and quantitative image analysis was used to measure mRNAs coding for CRH in the hypothalamic paraventricular nucleus (PVN) and thalamic center median-subfascicular complex (CM-Sf). Then, CRH neurons in the PVN were immunostained and the area of immunostaining was measured. Also, CRH fibers were immunostained in the central nucleus of the amygdala and the area of immunostaining was obtained. Finally, POMC mRNA expression was characterized in the hypothalamic infundibular nucleus. The groups were compared with ANOVA and Student-Newman-Keul’s (SNK) post hoc comparison. Results: CRH mRNA was significantly elevated in the caudal PVN in the MSR and SS animals compared to HSR animals (p < 0.05, SNK). There was a significant increase in average and total CRH-positive area in the MSR and SS groups compared to the HSR group (p < 0.05, SNK). There was also a significant increase in CRH volume in the MSR and SS groups compared to the HSR group (p < 0.05, SNK). In the CM-Sf, the average CRH optical density was significantly higher in the MSR and SS groups than in the HSR group (p < 0.05, SNK). In the central nucleus of the amygdala, the area of CRH fiber staining was significantly higher in the SS group than in the MSR or HSR groups (p < 0.05, SNK). There was no difference between the groups in POMC mRNA expression in the mediobasal hypothalamus. Conclusion: Macaques that exhibit immediate suppression of reproductive function upon stress are considered stress sensitive. These animals have elevated CRH in the hypothalamus and limbic structures, which may play a role in suppressing the hypothalamic-gonadal axis upon stress initiation.

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“…Firstly, acupuncture may mediate neurotransmitter release, 16 which results in the stimulation of gonadotrophin-releasing hormone secretion, thereby influencing the menstrual cycle and ovulation. 17 The production of neurotransmitters such as endogenous opioids may also inhibit central nervous system outflow and biological stress response. 18 Secondly, acupuncture may stimulate blood flow to the uterus by inhibiting uterine central sympathetic nerve activity.…”

Section: Introductionmentioning

confidence: 99%

Effects of Acupuncture on the Outcome of in Vitro Fertilisation and Intracytoplasmic Sperm Injection in Women with Polycystic Ovarian Syndrome

et al. 2013

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Background Different mechanisms have been described for the effects of acupuncture on fertility. Acupuncture may mediate neurotransmitter release, which results in the stimulation of gonadotrophin-releasing hormone secretion. The production of neurotransmitters such as endogenous opioids may also inhibit central nervous system outflow and biological stress response. Acupuncture may also stimulate blood flow to the uterus by inhibiting uterine central sympathetic nerve activity. Despite some evidence suggesting beneficial effects of acupuncture on in vitro fertilisation (IVF) success rates, recent clinical trials could not duplicate these effects, especially in patients who are infertile with polycystic ovarian syndrome (PCOS) who are undergoing IVF. Methods A total of 62 women with PCOS undergoing IVF/intracytoplasmic sperm injection (ICSI) at Shayamehr IVF Clinic in Tehran (Iran) participated in a randomised, controlled trial. Participants were randomly allocated to one of two groups: there were 31 women each in the acupuncture (group I) and control groups (group II). Acupuncture based on traditional Chinese medicine was performed in group I versus no adjunctive treatment in group II. All acupuncture procedures were performed in five sessions: start of downregulation, start of stimulation, 2 days before ovum pick-up, and immediately before and after embryo transfer. We measured the rate of oocytes in metaphase II, the fertilisation rate and the quality of embryos.Results Our results showed a statistically higher mean of good quality embryos in group I compared with group II ( p=0.044). However, the mean number of metaphase II oocytes retrieved

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Endogenous opioid peptides and the control of the menstrual cycle

Cited by 49 publications

References 21 publications

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Corticotropin-Releasing Hormone and Pro-Opiomelanocortin Gene Expression in Female Monkeys with Differences in Sensitivity to Stress

Effects of Acupuncture on the Outcome of in Vitro Fertilisation and Intracytoplasmic Sperm Injection in Women with Polycystic Ovarian Syndrome

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