Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans

Gustafsson, Lars E.; Leone, Anna; Persson, Mats A. A.; Wiklund, Peter; Moncada, Salvador

doi:10.1016/0006-291x(91)91268-h

Cited by 863 publications

(509 citation statements)

References 8 publications

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“…22 A variety of cell types, including the pulmonary endothelium, are potential sources of NO in the lung. 13 Nevertheless, the level of NO during exhalation differs in various pathophysiologic conditions; for examples, it is increased in patients with asthma, 23,24 bronchiectasis, 25 systemic lupus erythematosus, 26 and liver cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Reduced production of nitric oxide during haemodialysis

Sumino

Sato

Sakamaki³

et al. 1999

J Hum Hypertens

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Objective: To examine the influence of systemic nitric oxide (NO) synthesis on blood pressure in patients with chronic renal failure undergoing haemodialysis, since nitric oxides are susceptible to renal excretion or are dialysed, a different indicator that is unaffected by renal function, such as the level of exhaled NO was evaluated. We examined the levels of the endogenous NO before and after a haemodialysis session. Design and methods: We evaluated the serum concentrations of nitrite/nitrate and the rate of nitric oxide release into exhaled air in 10 patients with hypertension who were receiving maintenance haemodialysis. Results: The serum concentrations of nitrite/nitrate before haemodialysis were significantly higher than those in 10 normal controls (183 ؎ 151 M vs 42 ؎ 17 M, P Ͻ 0.05). These levels decreased signifi-

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Section: Discussionmentioning

confidence: 99%

Reduced production of nitric oxide during haemodialysis

Sumino

Sato

Sakamaki³

et al. 1999

J Hum Hypertens

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“…NO was first detected in exhaled breath samples in 1991 [3]. In 1992, NO was voted molecule of the year by the scientific journal Science [4].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Nasal Nitric Oxide Measurement with Computed Tomography Findings in Chronic Rhinosinusitis

Dabholkar

Saberwal

Velankar

et al. 2013

Indian J Otolaryngol Head Neck Surg

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Nitric oxide (NO) is a biological messenger produced by mammalian cells serving various functions including regulation of blood flow, platelet function, immunity, and neurotransmission. The paranasal sinuses and nasal mucosa are a major source of exhaled NO. The aim of the study is to compare the nasal NO (nNO) levels in patients with chronic rhinosinusitis with those of common cold patients and controls and to correlate CT scores with nNO levels. The nasal concentration of NO was measured by electroluminescence in 13 healthy volunteers, in 13 patients suffering from common cold and 13 patients with chronic rhinosinusitis. The concentration of NO was correlated with symptom scores, endoscopic findings and CT findings. The measured levels of NO did not differ between healthy volunteers and common cold patients, but they were significantly lower in patients suffering from chronic rhinosinusitis. As NO is a regulator of mucociliary activity and has bacteriostatic and antiviral effects, the decreased concentration of nNO in patients suffering from sinusitis suggests that lack of NO may contribute to the pathogenesis of this disease. Thus, nNO, which is easily measured, provides a valuable non-invasive objective measure of chronic rhinosinusitis.

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“…This species difference may be expected if, indeed, NO contributes to the regulation of pulmonary vascular tone in the horse because pulmonary vascular pressures in this species are significantly higher during exercise than other species, including man (Erickson et al 1990;West et al 1993;West & Mathieu-Costello, 1995 Nitric oxide and exercise in the horse Bauer et al (1994) bronchiectasis and sinus inversus, has been associated with a deficiency of NO in the paranasal sinuses (Lundberg et al 1995). Furthermore, nitrate-forming bacteria in the upper airways could also contribute to exhaled NO (Gerlach et al 1994 Several studies have suggested that NO in exhaled air could originate from the lower airways, particularly the terminal and respiratory bronchioles (Gustafsson et al 1991;Persson et al 1993;Cremona et al 1995). Persson et al (1993) found a correlation between [NO] and peak CO2 levels during a single exhalation in man and suggested that the vasculature lining the respiratory and terminal bronchioles contributed to NO in exhaled air.…”

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confidence: 98%

Nitric oxide and exercise in the horse.

Mills

Marlin

Demoncheaux

et al. 1996

The Journal of Physiology

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1. The effects of exercise on the production rate of nitric oxide (NO) in exhaled air (VNO) and 20 1 min-', respectively, and induced cyclical changes in the breathing pattern.4. Exercise induced a linear increase in VNO with work intensity to a maximum (428 1 + 31'6 pmol min-' kg-) which coincided with the maximal oxygen uptake for the horses (138 3 + 11 7 ml min-' kg-), although a further increase in VNO (779 3 + 38-4 pmol min-' kg-') occurred immediately after exercise. The changes in VNo correlated well with the tidal volume (r = 0-968; P < 0-01) and the haematocrit (r = 0-855; P < 0-01). 5. In the first 2 min of high intensity exercise, inhaled NO (80 p.p.m.) significantly (P < 0 05) reduced the pulmonary artery pressure: during the first minute, pulmonary artery pressure was 83-1 + 7-6 mmHg compared with a control value of 94 4 + 6-3 mmHg, and during the second minute, 84-2 + 7-1 mmHg compared with a control value of 98-4 + 4-7 mmHg.There were no other significant changes in cardiovascular or respiratory indices, including cardiac output, measured during exercise between control and inhaled NO tests. 6. The results show that exhaled NO is released from the airways of the horse and may contribute to the regulation of pulmonary vascular tone during exercise.

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Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans

Cited by 863 publications

References 8 publications

Reduced production of nitric oxide during haemodialysis

Reduced production of nitric oxide during haemodialysis

Correlation of Nasal Nitric Oxide Measurement with Computed Tomography Findings in Chronic Rhinosinusitis

Nitric oxide and exercise in the horse.

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