Reduced production of nitric oxide during haemodialysis

Sumino, Hiroyuki; Sato, Kunio; Sakamaki, Tatsuya; Kanda, Tsugiyasu; Nakamura, T.; Takahashi, Takashi; Sakamoto, Hirosuke; Kobayashi, Isao; Nagai, Ryouzou

doi:10.1038/sj.jhh.1000839

Cited by 11 publications

(7 citation statements)

References 28 publications

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“…Recently, a seasonal variation in plasma NO was reported with lowest levels occurring in the months of January and February (McLaren et al, 2000). The NO levels of healthy subjects studied in the months of February and May are in agreement with normal levels reported by other investigators: 28.9 AE 3.6 (Ochoa et al, 1991); 25.6 AE 10.3 (Yamamoto et al, 1998); 42 AE 17 (Sumimo et al, 1999);39.5 AE 19.4 (Gucuyener et al, 2000); and 33 AE 6 for males and 16.3 AE 3 (Taskiran et al, 2000) mM for females. The method of population multiple-component analysis requires that certain conditions be met regarding minimum sample size and minimum sampling rate (Fernandez and Hermida, 1998).…”

Section: Reprintssupporting

confidence: 89%

Altered Circadian Relationship Between Serum Nitric Oxide, Carbon Dioxide, and Uric Acid in Multiple Sclerosis

Kanabrocki

Ryan

Hermida

et al. 2004

Chronobiology International

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The free radical nitric oxide (NO*) is involved in a variety of diverse biological processes from acting as a vasodilator in the cardiovascular system to being the rate-limiting component in the production of peroxynitrite (ONOO-), a contributor to neurodegenerative disorders such as multiple sclerosis (MS). Uric acid (UA), the end product of purine metabolism in humans and a selective inhibitor of toxic reactions attributed to radicals formed by the interaction of ONOO- and CO2, is generally low in MS patients. We investigated the relationship between serum ONOO-, CO2, and UA in MS patients and normal controls by comparing the circadian characteristics of the NO* metabolites nitrite/ nitrate (NO), CO2, and UA. In this preliminary study, we found the functional relationship ascribed to the circadian timing of the peak and trough levels of NO, CO2, and UA in healthy subjects to be clearly altered in MS patients. These findings suggest that alterations in the temporal relationship between the 24h pattern in serum ONOO- formation and UA may either contribute to or reflect the disease processes in MS.

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Section: Reprintssupporting

confidence: 89%

Altered Circadian Relationship Between Serum Nitric Oxide, Carbon Dioxide, and Uric Acid in Multiple Sclerosis

Kanabrocki

Ryan

Hermida

et al. 2004

Chronobiology International

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“…Although studies of systemic production of NO in CRF patients have yielded contradictory results, 4,[29][30][31][32] our findings that l-arginine transport is increased in erythrocytes may reflect a broad activation of the l-arginine-NO pathway in cells of patients with CRF. Fig.…”

Section: Discussionmentioning

confidence: 69%

ACTIVATION OF l‐ARGININE TRANSPORT IN UNDIALYSED CHRONIC RENAL FAILURE AND CONTINUOUS AMBULATORY PERITONEAL DIALYSIS PATIENTS

Brunini

Roberts

Yaqoob

et al. 2006

Clin Exp Pharma Physio

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1. Treatment with haemodialysis and continuous ambulatory peritoneal dialysis (CAPD) presents different pathophysiological profiles and it has been suggested that clinical outcome in chronic renal failure may depend on the mode of dialysis. The transport of L-arginine, a precursor of nitric oxide, into blood cells is increased in uraemic patients on haemodialysis. The present study was designed to investigate L-arginine transport into red blood cells (RBC) in uraemic patients not yet on dialysis and on CAPD therapy. 2. Eleven uraemic patients not yet on dialysis and 17 on CAPD were included in the study. L-Arginine transport into RBC and plasma and RBC amino acid profiles were analysed in these sets of patients. 3. L-Arginine transport via system y(+), but not y(+)L, into RBC, was significantly increased in undialysed uraemic patients (459 +/- 40 micromol/L per cell per h) and CAPD patients (539 +/- 61 micromol/L per cell per h) compared with controls (251 +/- 39 micromol/L per cell per h). High-pressure liquid chromatography measurements demonstrated low levels of plasma L-arginine in uraemic patients both on CAPD (54 +/- 3 micromol/L) and not yet on dialysis (80 +/- 6 micromol/L) compared with control subjects (146 +/- 14 micromol/L). 4. Our findings provide the first evidence that uraemic patients not yet on dialysis and on CAPD present with an activation of L-arginine transport via system y(+) into RBC associated with reduced plasma levels of L-arginine.

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“…Nonetheless, research has suggested a possible association of increased NO metabolite concentrations in plasma with enhanced NO production and decreased renal function (25). The concentration of NO 2 − plus NO 3 − in serum has been observed to decrease more than either blood urea nitrogen (BUN) or creatinine following dialysis, and the concentrations of these 2 analytes have been suggested as a potential indicator of renal impairment (26). Similar associations of NO 3 − concentrations have been observed in pre- and postdialysis plasma (27).…”

Section: Discussionmentioning

confidence: 99%

“…Similar associations of NO 3 − concentrations have been observed in pre- and postdialysis plasma (27). Because salivary NO 3 − is reduced to NO 2 − by bacteria in the oral cavity (28) and because both NO 3 − and NO 2 − are removed from the blood by dialysis (26), salivary NO 2 − has also been selected as a suitable candidate marker for monitoring dialysis efficacy.…”

Section: Discussionmentioning

confidence: 99%

Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle

et al. 2008

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Background: Initial screening of potential biomarkers for monitoring dialysis was performed with saliva samples collected from patients with end-stage renal disease (ESRD). A more thorough analysis of the most promising markers identified in the initial screening was conducted with saliva samples acquired at hourly intervals throughout dialysis to monitor analyte concentrations as dialysis progressed. We observed that salivary nitrite (NO2−) and uric acid (UA) concentrations consistently decreased as dialysis proceeded. Methods: Solution-based colorimetric-detection chemistries for NO2− and UA were converted to a test strip format to produce a simple method for semiquantitatively measuring NO2− and UA concentrations in the clinic or at the patient’s home. We assessed the test strips with saliva samples collected from both ESRD patients undergoing dialysis and healthy control volunteers to qualitatively monitor the effect of dialysis on salivary NO2− and UA. We used computer software to analyze digital images of the resulting test strip color intensities. Results: Test strip measurements showed that mean salivary concentrations of NO2− and UA were decreased in ESRD patients by 86% and 39%, respectively, compared with 15% and 9% for time-matched controls. Comparison of test strip results with calibrated solution-based assays suggests that the test strips can semiquantitatively measure salivary concentrations of NO2− and UA. Conclusions: The colorimetric test strips monitored changes in salivary NO2− and UA concentrations that occurred in ESRD patients during dialysis. The test strips may prove useful for noninvasively evaluating dialysis progress and may also be useful for monitoring renal disease status.

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Reduced production of nitric oxide during haemodialysis

Cited by 11 publications

References 28 publications

Altered Circadian Relationship Between Serum Nitric Oxide, Carbon Dioxide, and Uric Acid in Multiple Sclerosis

Altered Circadian Relationship Between Serum Nitric Oxide, Carbon Dioxide, and Uric Acid in Multiple Sclerosis

ACTIVATION OF l‐ARGININE TRANSPORT IN UNDIALYSED CHRONIC RENAL FAILURE AND CONTINUOUS AMBULATORY PERITONEAL DIALYSIS PATIENTS

Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle

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