Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man

Deloose, Eveline; Vos, Rita De; Corsetti, Maura; Depoortere, Inge; Tack, Jan

doi:10.1111/nmo.12470

Cited by 55 publications

(66 citation statements)

References 52 publications

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“…However, we have reported recently that ghrelin plasma levels in humans do not fluctuate with the different phases of the MMC (20). We did confirm that motilin plasma levels peak before the occurrence of a phase III with gastric but not with duodenal onset (20).…”

Section: The Role Of the MMC And Motilin In Hunger Signalingsupporting

confidence: 76%

“…We did confirm that motilin plasma levels peak before the occurrence of a phase III with gastric but not with duodenal onset (20). Intrigued by the findings of Cannon and Washburn (11) and Carlson (12) and the link between the MMC and motilin, we studied the association of motilin plasma levels with the hunger sensation identified during phase III of the MMC (50).…”

Section: The Role Of the MMC And Motilin In Hunger Signalingmentioning

confidence: 77%

“…This hormone, produced by endocrine cells of the proximal small intestine, fluctuates in synchrony with the phases of the MMC and peaks just prior to the occurrence of a phase III with gastric but not with duodenal onset (Fig. 1B) (5,20,39,58). Further evidence of the involvement of motilin in the regulation of the MMC became evident when exogenous administration of motilin or the motilin receptor agonist erythromycin induced gastric phase III contractions (32,52,58).…”

Section: Control Of the MMC And Its Role In Small Intestinal Bacteriamentioning

confidence: 95%

“…Blood samples were taken every 10 min in a chilled LiHep tube containing aprotinin (500 kIU/ml). Samples were centrifuged at 4°C for 10 min at 3,000 g and plasma samples were analyzed by an in-house-developed radioimmunoassay for motilin (20). C: hunger scores were measured every 5 min on a visual analog scale of 100 mm with end points 0 mm ϭ not at all hungry and 100 mm ϭ as hungry as I have ever felt.…”

Section: Grantsmentioning

confidence: 99%

See 3 more Smart Citations

Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling

Deloose

Tack

2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: The Role Of the MMC And Motilin In Hunger Signalingsupporting

confidence: 76%

Section: The Role Of the MMC And Motilin In Hunger Signalingmentioning

confidence: 77%

Section: Control Of the MMC And Its Role In Small Intestinal Bacteriamentioning

confidence: 95%

Section: Grantsmentioning

confidence: 99%

See 2 more Smart Citations

Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling

Deloose

Tack

2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…The transient phase 4 of the cycle is not always observed. Despite over 40 years overpassing from the discovery of the MMC, the knowledge regarding its occurrence and control is still incomplete (Takahashi, 2013;Deloose et al, 2015). The mechanical correlates of the MR were also presented (Romański, 2009a).…”

Section: Introductionmentioning

confidence: 99%

The ‘minute rhythm’ incidence in the ovine abomasal antrum and small intestine

Romanski¹

2016

BJVM

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SummaryRomański, K. W., 2016. The 'minute rhythm' incidence in the ovine abomasal antrum and small intestine. Bulg. J. Vet. Med., 19, No 3,[200][201][202][203][204][205][206][207][208] To characterise further the 'minute rhythm', six healthy rams were equipped with serosal electrodes sewn onto the abomasal antrum and the small bowel. The experiments were performed before and after feeding. Food was offered during phase 2a or 2b of the migrating motility complex. The 'minute rhythm' incidence and coordination were assessed during four 5-minute observation periods. In the duodenal bulb and duodenum, the pattern was observed more frequently than in other segments examined. During phase 2b, the 'minute rhythm' incidence was often more frequent than during phase 2a of the migrating motility complex. Feeding increased significantly the 'minute rhythm' incidence, but these alterations were more evident during first two observation periods. In the jejunum, duration of one 'minute rhythm' episode was longer than in more proximal segments. In the more distal jejunal recording site the 'minute rhythm' was often absent. The pattern was well coordinated mostly in the antroduodenum and its propagation velocity was the highest also in the upper small bowel. It is concluded that the 'minute rhythm' incidence, form, and coordination depended upon the feeding conditions, intensity of intestinal motility and the gastrointestinal segment.

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Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract

Adriaenssens

Reimann

Gribble

2018

Comprehensive Physiology

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The enteroendocrine system of the gut acts both locally and peripherally, regulating gastrointestinal function as well as metabolism, energy expenditure, and central appetite control through the release of a variety of hormones. The chemosensing ability of enteroendocrine cells is integral to their role in eliciting physiological changes in response to fluctuations in the composition of the intestinal lumen. Regulation of enteroendocrine cell activity is complex, and requires that these cells can integrate signals deriving from dietary sources as well as the nervous and endocrine systems. Here, we provide an overview of enteroendocrine cell form and function, with a focus on new insights into their distribution throughout the intestine and the stimulus secretion coupling mechanisms underlying the activity of these important members of the gut-brain axis. © 2018 American Physiological Society. Compr Physiol 8:1603-1638, 2018.

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Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man

Abstract: These results confirm the role of motilin but not of ghrelin as an endogenous physiological regulator of the MMC with a gastric phase III.

Cited by 55 publications

References 52 publications

Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling

Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling

The ‘minute rhythm’ incidence in the ovine abomasal antrum and small intestine

Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract

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