Endogenous lipid pneumonia in rats after subacute exposure to CdCl2

Molina, AM; Raya, Ana I.; Carrasco, L.; Blanco, Alfonso; Jg, Monterde; Rueda, A; Moyano, Rosario

doi:10.1177/0748233708101208

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Cadmium (Cd), a relatively common heavy metal in the environment, is mainly produced as the result of industrial pollution (Bhattacharyya et al, 2000). In vivo experiments, acute or chronic exposure to Cd could cause injury to various tissues including that of liver, kidney, lung and bone (Molina et al, 2008;Orisakwe et al, 2007;Yokota and Tonami., 2008).…”

Section: Introductionmentioning

confidence: 99%

Roles of reactive oxygen species and mitochondria in cadmium-induced injury of liver cells

Liu

Bai

et al. 2010

Toxicol Ind Health

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The roles of reactive oxygen species (ROS) and mitochondrial damage in the cadmium (Cd)-induced injury of liver cells were studied by using N-acetyl-L-cysteine (NAC) and acetyl-L-carnitine hydrochloride (ALCAR). After exposure of experimental rats to cadmium (Cd) for 16 h, mitochondrial membrane potential (MMP), ROS production, glutathione peroxidase (GSH-Px) activity, glutathione (GSH) content, malondialdehyde (MDA) content and DNA single-strand break (DNA-SSB) were analyzed. Loss of MMP, increase of ROS production, inhibition of GSH-Px activity, elevation of GSH content, rise of MDA content and DNA-SSB level suggest the participation of ROS and mitochondrion in Cd-induced injury of liver cell. NAC pretreatment attenuated oxidative stress, reversed the decline in GSH-Px activity and reduced GSH and MDA levels significantly. However, Cd-induced loss in MMP was significantly exacerbated by NAC. For another, ALCAR did not perform as well as NAC in terms of reducing ROS production, restoring GSH-Px activity and reducing GSH content. Nevertheless, it significantly improved the recovery of MMP and reduction of MDA content. In addition, conspicuous DNA damage was observed in the samples treated with NAC or ALCAR, indicating Cd could attack DNA through other pathways. These results suggest that oxidative stress or mitochondrial impairment plays a main role in different injuries respectively.

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Section: Introductionmentioning

confidence: 99%

Roles of reactive oxygen species and mitochondria in cadmium-induced injury of liver cells

Liu

Bai

et al. 2010

Toxicol Ind Health

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“…Alveolar histiocytosis with alveolar, peribronchial, and subpleural aggregates of large foamy macrophages associated in some cases with subpleural aggregates of lymphocytes was also seen (Seguel et al 2017). It might be caused not only by immune activities related to parasites but by environmental toxicants as well (Molina et al 2008).…”

Section: Bronchopulmonary Immune Responsesmentioning

confidence: 99%

“…It might be caused not only by immune activities related to parasites but by environmental toxicants as well (Molina et al. 2008).…”

Section: Regional Immune Responsesmentioning

confidence: 99%

Physiological strategies in wild rodents: immune defenses of commensal rats

MIRKOV,

TUCOVIC,

KULAS

et al. 2023

Integr. Zool.

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The importance of issues associated with urban/commensal rats and mice (property damage, management costs, and health risks) press upon research on these animals. While the demography of commensal rodents is mostly studied, the need for understanding factors influencing their natural morbidity/mortality is also stressed. In this respect, more attention is expected to be paid to immunity, the physiological mechanism of defense against host survival threats (pathogens, parasites, diseases). Commensal rats and mice carry numerous pathogens that evoke diverse immune responses. The state of immunity in commensal house mice is studied in great detail, owing to the use of laboratory strains in biomedical research. Because commensal rats are, compared to mice, carriers of more zoonotic agents, rats' immunity is studied mainly in that context. Some of these zoonotic agents cause chronic, asymptomatic infections, which justified studies of immunological mechanisms of pathogen tolerance versus clearance regulation in rats. Occurrence of some infections in specific tissues/organs pressed upon analysis of local/regional immune responses and/or immunopathology. A survey of immunological activity/responses in commensal rats is given in this review, with mention of existing data in commensal mice. It should throw some light on the factors relevant to their morbidity and lifespan, supplementing the knowledge of commensal rodent ecology.

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The possible protective role of pumpkin seed oil in an animal model of acid aspiration pneumonia: Light and electron microscopic study

Omar

Sarhan

2017

Acta Histochemica

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Endogenous lipid pneumonia in rats after subacute exposure to CdCl2

Cited by 4 publications

References 13 publications

Roles of reactive oxygen species and mitochondria in cadmium-induced injury of liver cells

Roles of reactive oxygen species and mitochondria in cadmium-induced injury of liver cells

Physiological strategies in wild rodents: immune defenses of commensal rats

The possible protective role of pumpkin seed oil in an animal model of acid aspiration pneumonia: Light and electron microscopic study

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