The possible protective role of pumpkin seed oil in an animal model of acid aspiration pneumonia: Light and electron microscopic study

Omar, Nesreen Moustafa; Sarhan, Nahla Reda

doi:10.1016/j.acthis.2017.01.002

Cited by 7 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present results concerning analysis of the active constituents of PSO were in line with other studies reporting high amounts of free fatty acids (oleic, linoleic, palmitic, and stearic acids) in pumpkin oil 50 , 51 . Furthermore, results of the present study also agree with Omar and Sarhan 52 who attributed the improvement in acid-aspiration pneumonia model after pumpkin seed oil treatment to its composition.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

The potential role of pumpkin seeds oil on methotrexate-induced lung toxicity

Abosrea

Ezz

Mahmoud

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Many chemotherapeutic drugs cause adverse pulmonary reactions leading to severe pulmonary disease. Though methotrexate (MTX) is used for the treatment of cancer and other diseases, it is highly toxic with multiple adverse effects including pulmonary toxicity. Essential oils represent an open frontier for pharmaceutical sciences due to their wide range of pharmacological properties. Pumpkin seeds oil (PSO) was used to investigate its ability to alleviate methotrexate-induced lung toxicity in rats. Lung tissue from MTX-treated group revealed a decrease in malondialdehyde, glutathione, and nitric oxide accompanied by a marked inhibition in cholinesterase activity, and enhanced catalase activity, tumor necrosis factor-α, interleukin-6 and vascular endothelial growth factor levels. Analysis of PSO revealed that the oil was rich in hexadecanoic acid, decane methyl esters, squalene, polydecane, docosane, and other derivatives. Administration of PSO ameliorated the oxidant/antioxidant and proinflammatory changes induced by MTX in the lung tissue. Histological examinations confirmed the potency of PSO in reducing the histopathological alterations induced by MTX. Immunohistochemical analysis showed decreased nuclear factor-kappa B and caspase 3 expression after PSO. The present data indicated the protective efficiency of PSO against MTX-induced lung injury by decreasing oxidative damage, inflammation and apoptosis and could thus be recommended as an adjuvant therapy.

show abstract

Section: Discussionsupporting

confidence: 92%

“…Omar and Sarhan 52 found that pumpkin oil partially attenuated the histological and ultra structural alterations and reduced inducible NO synthase immune-expression in lung tissue of experimentally-induced acid aspiration pneumonia model.…”

Section: Discussionmentioning

confidence: 99%

The potential role of pumpkin seeds oil on methotrexate-induced lung toxicity

Abosrea

Ezz

Mahmoud

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The results revealed that lung tissue samples of the rats treated with pumpkin oil showed decreased interalveolar septa thickness, inflammatory cell infiltration, less collagenous fiber area, and immune expression of inducible nitric oxide synthase (iNOS) as compared to control group. Clinical symptoms of disturbed alveolocapillary membrane, degeneration of type II pneumocytes, and plentiful alveolar macrophages were also reduced significantly with the treatment of pumpkin seed oil (Omar and Sarhan 2017).…”

Section: Antimicrobial Activitymentioning

confidence: 90%

Pumpkin (Cucurbita pepo) Seed

Adsul¹,

Madkaikar

2020

Oilseeds: Health Attributes and Food Applications

View full text Add to dashboard Cite

A pumpkin seed, also known as a "pepita", means "little seed of squash". Cucurbita pepo is the pumpkin species of the genus: Cucurbita, family: Cucurbits, sub-family: Cucurbitaceae, genera: Cucurbita L. Cucurbita pepo L. is the species among Cucurbitaceae family having the greatest monetary value of the genus. The seeds are typically rather flat, asymmetrically oval, light green in color, and may have a white outer hull. The Cucurbita pepo seeds have potential application and can be used as an alternative oil and protein source in novel food formulations such as cooking oils, as an ingredient in margarine blends, flours for instant soups, cookies, etc.

show abstract

“…Pumpkin seed oil obtained from Cucurbita pepo presents a strong antioxidant activity and valuable nutritional benefits. It is useful for treating a range of diseases, such as benign prostatic hyperplasia (BPH), urinary disorders, hypertension, hyperlipidemia, diabetes, and cancer [ 115 ]. In an in vivo urodynamics study on rabbits, it was reported that a preparation of pumpkin seed oil reduced bladder pressure, improved bladder compliance, and reduced urethral pressure in rabbits [ 173 ].…”

Section: Introductionmentioning

confidence: 99%

Medicinal plants and natural products for treating overactive bladder

Chen,

Hoi,

Lee

2024

Chin Med

View full text Add to dashboard Cite

Background Overactive bladder (OAB) presents a high prevalence of 16–18% worldwide. The pathophysiology of OAB is still poorly understood while effective therapy or countermeasure are very limited. On the other hand, medicinal plants and herbal remedies have been utilized for treating lower urinary tract symptoms (LUTS) in both Eastern and Western cultures since ancient times. In recent years, accumulating progress has also been made in OAB treatment research by using medicinal plants. Methods Relevant literature on the studies of medicinal plants and herbs used to treat OAB was reviewed. The medicinal plants were summarized and categorized into two groups, single-herb medications and herbal formulations. Results The present review has summarized current understanding of OAB’s pathophysiology, its available treatments and new drug targets. Medicinal plants and natural products which have been used or have shown potential for OAB treatment were updated and comprehensively categorized. Studies on a wide variety of medicinal plants showed promising results, although only a few phytochemicals have been isolated and identified. Until now, none of these herbal compounds have been further developed into clinical therapeutics for OAB. Conclusions This review provides the basis for discovering and designing new phytopharmaceutical candidates with effective and well-tolerated properties to treat OAB. Increasing evidences indicate new strategies with alternative herbal treatment for OAB have high efficacy and safety, showing great promise for their clinical use. Future studies in a rigorously designed controlled manner will be beneficial to further support the eligibility of herbal treatment as OAB therapeutics.

show abstract

The possible protective role of pumpkin seed oil in an animal model of acid aspiration pneumonia: Light and electron microscopic study

Cited by 7 publications

References 48 publications

The potential role of pumpkin seeds oil on methotrexate-induced lung toxicity

The potential role of pumpkin seeds oil on methotrexate-induced lung toxicity

Pumpkin (Cucurbita pepo) Seed

Medicinal plants and natural products for treating overactive bladder

Contact Info

Product

Resources

About