Endogenous IL-15 might be responsible for early protection by natural killer cells against infection with an avirulent strain of <i>Salmonella choleraesuis</i> in mice

Hirose, Kenji; Nishimura, Hitoshi; Matsuguchi, Tetsuya; Yoshikai, Yasunobu

doi:10.1002/jlb.66.3.382

Cited by 40 publications

(30 citation statements)

References 52 publications

(75 reference statements)

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“…Depletion of NK cells hampered the exclusion of bacteria in IL-15-Tg mice after BCG infection. We have previously reported that NK cells increased at the earlier stage after avirulent strain of S. choleraesuis and neutralization of endogenous IL-15 by in vivo administration with anti-IL-15 mAb inhibited the appearance of NK cells and exacerbated the infection (25,36,37). Taken together, it appears that IL-15 may serve to induce proliferation and/or accumulation of NK cells during BCG infection, and the increase in number of NK cells is at least partly responsible for the enhanced resistance against BCG infection in IL-15-Tg mice.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of IL-15 In Vivo Enhances Protection AgainstMycobacterium bovisBacillus Calmette-Guérin Infection Via Augmentation of NK and T Cytotoxic 1 Responses

Umemura

Nishimura

Hirose

et al. 2001

The Journal of Immunology

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To investigate the immunomodulating effects of IL-15 in vivo on mycobacterial infection, we used IL-15-transgenic (Tg) mice, which were recently constructed with cDNA-encoding secretable isoform of IL-15 precursor protein under the control of a MHC class I promoter. The IL-15-Tg mice exhibited resistance against infection with Mycobacterium bovis bacillus Calmette-Guérin (BCG), as assessed by bacteria growth. IFN-γ level in serum was significantly higher in IL-15-Tg mice than in non-Tg mice after BCG infection. NK cells were remarkably increased, and Ag-specific T cytotoxic 1 response mediated by CD8+ T cells producing IFN-γ was significantly augmented in the IL-15-Tg mice following BCG infection. Neutralization of endogenous IFN-γ by in vivo administration of anti-IFN-γ mAb deteriorated the clearance of the bacteria. Depletion of of NK cells or CD8+ T cells by invivo administration of anti-asialo-GM1 Ab or anti-CD8 mAb hampered the exclusion of bacteria. Thus, overexpression of IL-15 in vivo enhanced protection against BCG infection via augmentation of NK and T cytotoxic 1 responses.

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Section: Discussionmentioning

confidence: 99%

Overexpression of IL-15 In Vivo Enhances Protection AgainstMycobacterium bovisBacillus Calmette-Guérin Infection Via Augmentation of NK and T Cytotoxic 1 Responses

Umemura

Nishimura

Hirose

et al. 2001

The Journal of Immunology

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“…For example, the protective role of NK cells was demonstrated in infections induced by M. avium, M. lepraemurium or M. tuberculosis (20)(21)(22)(23)194,195). The protective role of NK cells was also demonstrated in models of infection with different strains of Salmonella (196)(197)(198). Similarly, NK cells were shown to play a critical protective role against S. aureus in septic arthritis and pulmonary models of infection (199,200).…”

Section: Benefits Versus Disadvantages Of Nk Cell Activation During Bmentioning

confidence: 99%

Natural Killer (NK) Cells in Antibacterial Innate Immunity: Angels or Devils?

Souza-Fonseca-Guimarães

Adib‐Conquy

Cavaillon

2011

Mol Med

133

125

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Natural killer (NK) cells were first described as immune leukocytes that could kill tumor cells and soon after were reported to kill virus-infected cells. In the mid-1980s, 10 years after their discovery, NK cells were also demonstrated to contribute to the fight against bacterial infection, particularly because of crosstalk with other leukocytes. A wide variety of immune cells are now recognized to interact with NK cells through the production of cytokines such as interleukin (IL)-2, IL-12, IL-15 and IL-18, which boost NK cell activities. The recent demonstration that NK cells express pattern recognition receptors, namely Toll-like and nucleotide oligomerization domain (NOD)-like receptors, led to the understanding that these cells are not only under the control of accessory cells, but can be directly involved in the antibacterial response thanks to their capacity to recognize pathogen-associated molecular patterns. Interferon (IFN)-γ is the predominant cytokine produced by activated NK cells. IFN-γ is a key contributor to antibacterial immune defense. However, in synergy with other inflammatory cytokines, IFN-γ can also lead to deleterious effects similar to those observed during sepsis. Accordingly, as the main source of IFN-γ in the early phase of infection, NK cells display both beneficial and deleterious effects, depending on the circumstances.

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“…V gene usage in total RNA extracted from sorted 26,29) We found failure of IL-15 mRNA expression in i-EC from LPS-nonresponder mice (Fig. 1).…”

Section: No Difference In Tcra Ab B and Tcrg Gd D Subsets In I-iel Bementioning

confidence: 85%

“…6 infections with Gram-positive L. monocytogenes and Gramnegative S. choleraesuis. 29,30) To confirm whether bacterial infections increase the IL-15 transcription and development of TCRab CD8aa i-IEL, 4ϫ10…”

Section: No Difference In Tcra Ab B and Tcrg Gd D Subsets In I-iel Bementioning

confidence: 99%

Development of TCR.ALPHA..BETA. CD8.ALPHA..ALPHA. Intestinal Intraepithelial Lymphocytes Is Promoted by Interleukin-15-Producing Epithelial Cells Constitutively Stimulated by Gram-Negative Bacteria via TLR4

Kaneko

Mizunuma

Takimoto

et al. 2004

Biological & Pharmaceutical Bulletin

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Endogenous IL-15 might be responsible for early protection by natural killer cells against infection with an avirulent strain of Salmonella choleraesuis in mice

Cited by 40 publications

References 52 publications

Overexpression of IL-15 In Vivo Enhances Protection AgainstMycobacterium bovisBacillus Calmette-Guérin Infection Via Augmentation of NK and T Cytotoxic 1 Responses

Overexpression of IL-15 In Vivo Enhances Protection AgainstMycobacterium bovisBacillus Calmette-Guérin Infection Via Augmentation of NK and T Cytotoxic 1 Responses

Natural Killer (NK) Cells in Antibacterial Innate Immunity: Angels or Devils?

Development of TCR.ALPHA..BETA. CD8.ALPHA..ALPHA. Intestinal Intraepithelial Lymphocytes Is Promoted by Interleukin-15-Producing Epithelial Cells Constitutively Stimulated by Gram-Negative Bacteria via TLR4

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