Endogenous hydrocortisone caused metabolic perturbation and nutritional deterioration of animal-derived food in a dose-dependent manner

Jia, Wei; Wang, Xin; Shi, Lin

doi:10.1016/j.foodchem.2022.134145

Cited by 16 publications

(10 citation statements)

References 30 publications

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“…In the field of food and drug research, functional active substances sensitive to the external environments such as light, temperature, and pH value are often embedded to improve their water solubility, improve stability, control delivery and release, and then improve bioavailability. The commonly used embedding systems include nanoparticles, emulsions and microcapsules ( Jia, Wang, & Shi, 2023 ). Due to the chemical structure characteristics of oil, it is sensitive to temperature, light, and oxygen, and easy to be oxidized by environmental factors.…”

Section: Oil Oxidation Mechanism and Inhibition Strategymentioning

confidence: 99%

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

2023

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Section: Oil Oxidation Mechanism and Inhibition Strategymentioning

confidence: 99%

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

2023

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“…The generated list was submitted to LIPID MAPS, KEGG, HMDB, and the built-in database for searching possible lipid structures. Precursors unmatched by the search results were discarded and the specific headgroup filter for glycerophospholipids was applied . (iii) Calculate the mass accuracy error.…”

Section: Resultsmentioning

confidence: 99%

“…Precursors unmatched by the search results were discarded and the specific headgroup filter for glycerophospholipids was applied. 31 (iii) Calculate the mass accuracy error. The precursor m/z value and molecular formula obtained from the database search were used for evaluating mass accuracy and calculating the isotopic distribution score.…”

Section: Lipid Alternation In Relation To Different Residue Time Of C...mentioning

confidence: 99%

Spatiotemporal Variation of Residual Cortisol Obstructs Nutrient Acquisition in Animal-Derived Foods by Perturbing Glycerophospholipid Metabolism

Jia

Shi

2023

J. Agric. Food Chem.

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Cortisol is inevitably secreted by pigs due to the physical and psychological stressors produced by mixed group transportation and preslaughter handling. Accumulated cortisol in animal tissues enters the human body through the food chain and entails potential risks to human health. An integrated lipidome and proteome analysis was conducted to investigate the effect of the spatiotemporal variation of residual cortisol on nutrient acquisition in pork. A total of 55 crucial lipid molecules associated with cortisol residue were identified based on debiased sparse partial correlation analysis. Label-free proteomics was applied to screen 58 differentially abundant proteins (including phospholipase A 2 , lysophosphatidylcholine acyltransferase, and CTP:phosphocholine cytidylyltransferase), indicating that cortisol residue perturbed the glycerophospholipid biosynthetic process and glycerophospholipid metabolic process. Cortisol induced downregulations of cPLA2 encoding genes and decreased phospholipase A 2 activity, resulting in the bioaccumulation of phosphatidylethanolamine (from 36.86 to 43.18 mg kg −1 ). Cortisol increased the activity of CTP:phosphocholine cytidylyltransferase by improving the availability of fatty acids and aggregating the inactive L-form (lipidindependent form) to the active H-form (lipid-associated form). The metabolic pathways perturbed by cortisol resulted in phosphatidylcholine degradation (from 93.73 to 58.28 mg kg −1 ) and lysophosphatidylcholine accumulation (from 3.39 to 5.16 mg kg −1 ). These findings indicated that cortisol residue deteriorated meat quality and obstructed nutrient acquisition in animal-origin foods.

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“…The present research mainly focused on volatile compounds’ variation during aging period, the characterization of non-volatiles is lacked ( Huang et al, 2019 ). Thus, a considerable amount of research on the Baijiu system variation during aging period need to be further investigated, especially various types of Baijiu to search for common rules and aging markers which could contribute to the quality control and improvement of Baijiu ( Jia, Wang, & Shi, 2023c ). In addition, the future research of Baijiu should be adhered to the dual guidance of flavor and health ( Li, Yuan, Yong, Zhao, & Liu, 2020b ).…”

Section: Challenges and Perspectivesmentioning

confidence: 99%

Endogenous hydrocortisone caused metabolic perturbation and nutritional deterioration of animal-derived food in a dose-dependent manner

Cited by 16 publications

References 30 publications

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

Spatiotemporal Variation of Residual Cortisol Obstructs Nutrient Acquisition in Animal-Derived Foods by Perturbing Glycerophospholipid Metabolism

Synergy of physicochemical reactions occurred during aging for harmonizing and improving flavor

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