Synergy of physicochemical reactions occurred during aging for harmonizing and improving flavor

Jia, Wei; Ma, Rutian; Hu, Liangbin; Mo, Haizhen

doi:10.1016/j.fochx.2022.100554

Cited by 11 publications

(9 citation statements)

References 66 publications

(79 reference statements)

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“…As a new material, MPN has the advantages of convenient materials and simple assembly. Because it has the functions of inhibiting microbial growth, scavenging free radicals and blocking ultraviolet rays, it has great development potential in the field of the food industry ( Jia, Ma, Hu, & Mo, 2023 ).…”

Section: Natural Antioxidantsmentioning

confidence: 99%

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

2023

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Section: Natural Antioxidantsmentioning

confidence: 99%

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

2023

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“…Existing computational methods for building coessentiality networks depend largely on the Pearson correlation, which are not suitable for distinguishing direct/indirect associations among compounds and lead to false-positive edges in the biological network . Gaussian graphical models compute partial correlations and provide a unique advantage by automatically removing indirect associations in the network compared with Pearson correlation networks, thereby reducing false-positive rates and generating high-confidence sets of presumptive interactions for subsequent validation. , A debiased sparse partial correlation algorithm as a Gaussian graphical model technique was applied to model a network revealing connectivity patterns and correlations between lipid molecules and cortisol (Figure A). Nodes represent various lipid molecules and edges represent the association between lipid molecules and cortisol in a debiased sparse partial correlation network.…”

Section: Resultsmentioning

confidence: 99%

Spatiotemporal Variation of Residual Cortisol Obstructs Nutrient Acquisition in Animal-Derived Foods by Perturbing Glycerophospholipid Metabolism

Jia

Shi

2023

J. Agric. Food Chem.

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Cortisol is inevitably secreted by pigs due to the physical and psychological stressors produced by mixed group transportation and preslaughter handling. Accumulated cortisol in animal tissues enters the human body through the food chain and entails potential risks to human health. An integrated lipidome and proteome analysis was conducted to investigate the effect of the spatiotemporal variation of residual cortisol on nutrient acquisition in pork. A total of 55 crucial lipid molecules associated with cortisol residue were identified based on debiased sparse partial correlation analysis. Label-free proteomics was applied to screen 58 differentially abundant proteins (including phospholipase A 2 , lysophosphatidylcholine acyltransferase, and CTP:phosphocholine cytidylyltransferase), indicating that cortisol residue perturbed the glycerophospholipid biosynthetic process and glycerophospholipid metabolic process. Cortisol induced downregulations of cPLA2 encoding genes and decreased phospholipase A 2 activity, resulting in the bioaccumulation of phosphatidylethanolamine (from 36.86 to 43.18 mg kg −1 ). Cortisol increased the activity of CTP:phosphocholine cytidylyltransferase by improving the availability of fatty acids and aggregating the inactive L-form (lipidindependent form) to the active H-form (lipid-associated form). The metabolic pathways perturbed by cortisol resulted in phosphatidylcholine degradation (from 93.73 to 58.28 mg kg −1 ) and lysophosphatidylcholine accumulation (from 3.39 to 5.16 mg kg −1 ). These findings indicated that cortisol residue deteriorated meat quality and obstructed nutrient acquisition in animal-origin foods.

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“…As illustrated by Figure i, the pocket of trypsin activity was flanked by glutamate residues, which contained two carboxyl groups. Due to the electronegativity of the O in the carboxyl group, electron cloud was delocalized at the carbonyl, hydroxyl, and ether bonds and transferred to the ester and carboxyl groups, which endowed the glutamate residues with electron-absorbing properties. , The inducible effect between the junction of the metabolite and glutamic acid residues on the outside of the pocket of trypsin activity resulted in the shift of the sides in pocket toward the junction of the metabolite.…”

Section: Resultsmentioning

confidence: 99%

Lactobacillus casei-Derived Postbiotics Elevate the Bioaccessibility of Proteins via Allosteric Regulation of Pepsin and Trypsin and Introduction of Endopeptidases

Fan

Jia

2023

J. Agric. Food Chem.

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The potential of probiotics to benefit digestion has been widely reported, while its utilization in high-risk patients and potential adverse reactions have focused interest on postbiotics. A variable data-independent acquisition (vDIA)-based spatial-omics strategy integrated with unsupervised variational autoencoders was applied to profile the functional mechanism underlying the action of Lactobacillus casei-derived postbiotic supplementation in goat milk digestion in an infant digestive system, from a metabolomics− peptidomics−proteomics perspective. Amide and olefin derivatives were proved to elevate the activities of pepsin and trypsin through hydrogen bonding and hydrophobic forces based on allosteric effects, and recognition of nine endopeptidases and their cleavage to serine, proline, and aspartate were introduced by postbiotics, thereby promoting the generation of hydrophilic peptides and elevating the bioaccessibility of goat milk protein. The peptides originating from αs1-casein, β-casein, β-lactoglobulin, Ig-like domain-containing protein, κ-casein, and serum amyloid A protein, with multiple bioactivities including angiotensin I-converting enzyme (ACE)-inhibitory, osteoanabolic, dipeptidyl peptidase IV (DPP-IV) inhibitory, antimicrobial, bradykinin-potentiating, antioxidant, and anti-inflammatory activities, were significantly increased in the postbiotic supplementation group, which was also considered to potentially prevent necrotizing enterocolitis through inhibiting the multiplication of pathogenic bacteria and blocking signal transducer and activator of transcription 1 and nuclear factor kappa-light-chain-enhancer of activated B cells inflammatory pathways. This research deepened the understanding of the mechanism underlying the postbiotics affecting goat milk digestion, which established a critical groundwork for the clinical application of postbiotics in infant complementary foods.

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Synergy of physicochemical reactions occurred during aging for harmonizing and improving flavor

Cited by 11 publications

References 66 publications

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

RETRACTED: Integrated the embedding delivery system and targeted oxygen scavenger enhances free radical scavenging capacity

Spatiotemporal Variation of Residual Cortisol Obstructs Nutrient Acquisition in Animal-Derived Foods by Perturbing Glycerophospholipid Metabolism

Lactobacillus casei-Derived Postbiotics Elevate the Bioaccessibility of Proteins via Allosteric Regulation of Pepsin and Trypsin and Introduction of Endopeptidases

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