Endogenous Formation of Carbon Monoxide in Man

Sjöstrand, Torgny

doi:10.1038/164580a0

Cited by 103 publications

(51 citation statements)

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“…Recent studies performed in our laboratory (1) have confirmed the finding of Sjdstrand (2,3) that carbon monoxide is produced in normal man. In 10 normal subjects the average rate of production of carbon monoxide was found to be 0.42 (SE of mean + 0.02) ml per hour.…”

supporting

confidence: 65%

Effect of Erythrocyte Destruction on Carbon Monoxide Production in Man*

Coburn¹,

Williams²,

Forster³

1964

J. Clin. Invest.

106

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Recent studies performed in our laboratory (1) have confirmed the finding of Sjdstrand (2, 3) that carbon monoxide is produced in normal man. In 10 normal subjects the average rate of production of carbon monoxide was found to be 0.42 (SE of mean + 0.02) ml per hour. The present study is an attempt to clarify the processes that result in the production of this gas in the body.A number of studies have been performed that suggest that CO may be an in vivo catabolic byproduct of hemoglobin. Sj6strand and associates have demonstrated that the blood carboxyhemoglobin concentration [COHb] becomes elevated in man after intramuscular or intravenous injection of blood or hemoglobin (3) and intravenous injection of damaged erythrocytes or nicotinic acid (4). Sj6strand (3) and later Engstedt (5) and Oski and Altman (6) noted that the blood [COHb] level is elevated in patients with hemolysis. Chemical studies by Sj6strand (7,8) and Ludwig, Blakemore, and Drabkin (9) have demonstrated that treatment of hemoglobin (7,8) and pyridine hemochromogen (9) with hydrogen peroxide and ascorbic acid results in CO formation. In the latter study the bridge and adjacent carbon atoms of heme were labeled with C14, and the CO formed was found to be radioactive, indicating that CO probably arose from a methene bridge carbon atom.* Submitted for publication November 18, 1963; ac- (10) have shown that coupled oxidation of heme is a different reaction than occurs physiologically during heme catabolism in that the porphyrin ring is apparently randomly opened at any of the four methene bridge carbon atoms rather than at the alpha position as occurs in vivo (11). Because of these uncertainties, our method for estimating in vivo CO production quantitatively was applied to this problem. This paper contains data on measurements of the rate of endogenous carbon monoxide production following the intravenous injection of damaged erythrocytes in man. MethodsEndogenous CO production was measured by the "rebreathing method" described in greater detail elsewhere (1). The principle of this method is that CO excretion from the body, which occurs via the lungs, is inhibited by having the subject rebreathe in a closed system. Endogenous CO production is then calculated from the rate of increase in venous blood [COHb] during rebreathing and the effective blood volume, both of which are measured in every study. With this technique the production of CO per hour, calculated from two blood samples, drawn at the beginning and end of the period, could be estimated in each hour with an error of less than ± 0.2 ml. Greater precision was ob-1098

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supporting

confidence: 65%

Effect of Erythrocyte Destruction on Carbon Monoxide Production in Man*

Coburn¹,

Williams²,

Forster³

1964

J. Clin. Invest.

106

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“…These pioneer studies initiated a century of investigations for the biological actions of CO. In the early 1950s, Sjöstrand for the first time provided actual experimental evidence for the existence of CO in our body (Sjöstrand, 1950 and1952). He observed that decomposition of hemoglobin in vivo produced CO. Endogenous production of CO can be regulated.…”

Section: A Endogenous Production Of Carbon Monoxidementioning

confidence: 99%

Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications

Wang²

2005

Pharmacol Rev

826

736

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“…Со времени обнаружения Торгни Сьйостран-дом (1949) эндогенной продукции монооксида углерода в организме человека в дальнейших ис-следованиях установлена роль этого химического соединения в реализации множественных физио-логических функций и патологических эффектов [1][2][3]. В настоящее время монооксид углерода (СО) рассматривается как эндогенно продуци-руемый газовый трансмиттер, ответственный за цитопротекцию и регуляцию гомеостаза в совер-шенно отличающихся друг от друга типах клеток и тканях [2][3][4].…”

Section: Introductionunclassified

Моніторинг Вмісту В Крові Карбоксигемоглобіну Для Оцінки Тяжкості Травматичного Шоку Та реперфузійних Ушкоджень (Аналітичний Огляд З Результатами Власних Спостережень)

Kursov¹,

Beletskiy²,

Lyzogub³

et al. 2022

ЕМ

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Endogenous Formation of Carbon Monoxide in Man

Cited by 103 publications

References 0 publications

Effect of Erythrocyte Destruction on Carbon Monoxide Production in Man*

Effect of Erythrocyte Destruction on Carbon Monoxide Production in Man*

Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications

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