Endogenous endothelin in a rat model of acute colonic mucosal injury

Sugimachi, Masamitsu; Kiyohara, Tatsuya; Murayama, Yoko; Minami, Takeshi; Miyazaki, Yoshiji; Miyagawa, Jun‐ichiro; Shinomura, Yasuhisa; Matsuzawa, Yūji

doi:10.1046/j.1440-1746.2000.02311.x

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…It contributes to the regulation of blood pressure by vasoconstriction [148], but is also known to play a role in the regulation of gastrointestinal function [149][150][151]. Endothelin-1 is overexpressed in Kaposi's sarcoma lesions and promotes invasiveness as well as tumor growth in an autocrine fashion [152].…”

Section: Positive and Negative Regulation Of Tumor Cell Migrationmentioning

confidence: 99%

Inhibitors for Metastasis Development

Lang¹,

Drell²,

Zaenker³

et al. 2006

PRA

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A leading cause of death, cancer remains the bane of modern society and one of the most challenging research fields. Cancer is initially a localized disease that can be often treated well at a very early stage. However the vast majority of cancer deaths result from a pernicious progression of the disease, the development of distant metastases. It must therefore be a pressing research goal to focus on the pharmacological prevention of metastasis development. This review summarizes the current understanding of the cellular and molecular mechanisms of metastasis development, and suggests possible approaches for its inhibition.

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Section: Positive and Negative Regulation Of Tumor Cell Migrationmentioning

confidence: 99%

Inhibitors for Metastasis Development

Lang¹,

Drell²,

Zaenker³

et al. 2006

PRA

View full text Add to dashboard Cite

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Irritable bowel syndrome with constipation: issues of pathogenesis, diagnostics and treatment

2020

Actual Problems of Modern Medicine

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Issues related to the diagnosis and treatment of irritable bowel syndrome occupy one of the central places in gastroenterology, due to the fact that in recent years there has been a significant increase in the incidence of this syndrome, its long-term recurrent, often lifelong course, leading to a decrease in the performance of patients, despite good quality, and a significant cost to the health care system. Irritable bowel syndrome, despite its functional nature, occurs quite often - from 14-50% of the adult population according to population epidemiological studies, and the ratio of women to men is from 2: 1 to 4:1. In the structure of gastroenterological pathology, this disease accounts for 40-70% of all cases of seeking medical help. Irritable bowel syndrome is a complex of functional disorders of the distal intestines, lasting more than 3 months and accompanied by abdominal pain that disappears after a bowel movement, flatulence, a feeling of incomplete bowel movement, changes in the frequency and consistency of stools. Factors in the pathogenesis of irritable bowel syndrome are dysfunction of mental activity with changes in autonomic and humoral functions; visceral hypersensitivity and impaired intestinal motility, past intestinal infection; endocrine disorders; food allergies, sedentary lifestyle; genetic predisposition. Endothelial dysfunction has recently played an important role in the onset of irritable bowel syndrome. The most famous among the factors of vascular endothelium today are the powerful vasoconstrictor endothelin-1 and the vasodilator - nitric oxide. The study investigated the level of vasoconstrictor endothelin-1 and vasodilator of nitric oxide in patients with irritable bowel syndrome with constipation. It was found that such patients have severe endothelial dysfunction, which manifests itself in an increase in the level of endothelin-1 (р˂0,01), a decrease in the level of nitric oxide (р˂0,01). The data obtained indicate the role of dysfunction of the vascular endothelium in the pathogenesis of irritable bowel syndrome with constipation. An inverse correlation was found between the content of endothelin-1 and nitric oxide (p˂0.01), which indicates an increase in the activity of vasoconstrictor mechanisms with a simultaneous decrease in vasodilation factors. The effectiveness of complex therapy in the group of patients in whom folic acid and zincteral were used as part of complex therapy in improving the clinical picture of the disease (complete relief of dyspeptic syndrome and a significant decrease in the severity of pain, constipation and asthenic syndromes), restoration of vascular endothelial function (significant decrease in the level of endothelin-1 and an increase in the level of nitric oxide) in comparison with the group of patients in the treatment of which only basic therapy was used.

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Role of endothelin-1 in the gastrointestinal tract of horses in health and disease

Chidambaram¹

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Endogenous endothelin in a rat model of acute colonic mucosal injury

Abstract: Endothelin may play a role in the host response to acute mucosal damage. Mucosal ET production is significantly affected by mucosal injury.

Cited by 4 publications

References 21 publications

Inhibitors for Metastasis Development

Inhibitors for Metastasis Development

Irritable bowel syndrome with constipation: issues of pathogenesis, diagnostics and treatment

Role of endothelin-1 in the gastrointestinal tract of horses in health and disease

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