2006
DOI: 10.2174/157489206775246511
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Inhibitors for Metastasis Development

Abstract: A leading cause of death, cancer remains the bane of modern society and one of the most challenging research fields. Cancer is initially a localized disease that can be often treated well at a very early stage. However the vast majority of cancer deaths result from a pernicious progression of the disease, the development of distant metastases. It must therefore be a pressing research goal to focus on the pharmacological prevention of metastasis development. This review summarizes the current understanding of t… Show more

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Cited by 10 publications
(8 citation statements)
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“…It seems worth of note in this context, that stress has an influence on the estrogen metabolism, too [34]. As high concentrations or prolonged exposure to estrogen are known risk factors for breast cancer [35], an impaired estrogen production due to chronic stress might under certain conditions have a cancer-protective function [36].…”
Section: Epidemiological Aspectsmentioning
confidence: 99%
“…It seems worth of note in this context, that stress has an influence on the estrogen metabolism, too [34]. As high concentrations or prolonged exposure to estrogen are known risk factors for breast cancer [35], an impaired estrogen production due to chronic stress might under certain conditions have a cancer-protective function [36].…”
Section: Epidemiological Aspectsmentioning
confidence: 99%
“…Nonetheless, approximately 30% of treated BC patients develop distant metastases [5] and these significantly account for 90% of breast cancer deaths [6]. Consequently, therapeutic strategies are needed that target metastasis [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…Endocrine therapy has been shown to have a positive effect on the treatment of advanced metastatic disease (1, 2). Despite these positive effects, initial or acquired resistance to endocrine therapies frequently occurs with tumors recurring as metastasis, which is the leading cause of death from breast cancer.…”
Section: Introductionmentioning
confidence: 99%