Endogenous Electric‐Field‐Coupled Electrospun Short Fiber via Collecting Wound Exudation

Abstract

Endogenous electric fields (EF) are the basis of bioelectric signal conduction and the priority signal for damaged tissue regeneration. Tissue exudation directly affects the characteristics of endogenous EF. However, current biomaterials lead to passive repair of defect tissue due to limited management of early wound exudates and inability to actively respond to coupled endogenous EF. Herein, the 3D bionic short‐fiber scaffold with the functions of early biofluid collection, response to coupled endogenous EF, is constructed by guiding the short fibers into a 3D network structure and subsequent multifunctional modification. The scaffold exhibits rapid reversible water absorption, reaching maximum after only 30 s. The stable and uniform distribution of polydopamine‐reduced graphene oxide endows the scaffold with stable electrical and mechanical performances even after long‐term immersion. Due to its unique ‐ bionic structure and tissue affinity, the scaffold further acts as an “electronic skin,” which transmits endogenous bioelectricity via absorbing wound exudates, promoting the treatment of diabetic wounds. Furthermore, under the endogenous EF, the cascade release of vascular endothelial growth factor accelerates the healing process. Thus, the versatile scaffold is expected to be an ideal candidate for repairing different defect tissues, especially electrosensitive tissues.

Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes

“…1 e). Moreover, PDA functionalization endows the material with immunomodulatory activity [ 28 ]. The cell adhesion and ROS-scavenging properties of the PDA synergistically endowed the scaffold with an immunomodulatory activity that reduced M1 macrophage polarization to downregulate inflammatory cytokines, and activated M2 macrophages to secrete osteogenesis-related cytokines ( Fig.…”

“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

“…The management of peri-wound exudate has been a common but neglected problem during wound treatment (Qi et al, 2021). Thus, prevention and control of peri-wound biofluids, such as timely hemostasis and removal of surplus biofluids, is an integral part of the wound healing process that cannot be ignored (Wang et al, 2022). Hydrophilic materials are known to absorb biological fluids such as chitosan (CTS) and polyvinyl alcohol (PVA), among other substances (Arima and Iwata, 2007;Ahmed et al, 2018;Morgado et al, 2017).…”

An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing

“…Various biomaterials have been used for skin tissue regeneration and repair, such as hydrogels [ 31 , 32 ], nanofibers [ 14 , 33 ]. However, the practical application of these biomaterials depends on their ability to meet the complicated functional requirements of the injured tissue.…”

“…As a new two-dimensional transition metal material, MXene with unique chemical and physical properties [ 14 , 38 ], especially high photothermal conversion efficiency attracted biomaterials researches to expand its biomedical applications [ 39 , 40 ]. In this study, based on MXene, we have developed a NIR-responsive band-aid (MNFs@V–H@DA, that is, MXene nanofibers @ VEGF core with dopamine-hyaluronic acid hydrogel@DA shell), combining advantages of nanofibers and hydrogels [ 33 , 41 , 42 ]. The results indicated that the obtained MNFs@V–H@DA with suitable NIR laser irradiation condition promoted vascularization and regulated the immune microenvironment at the wound site to achieve better wound healing, which effectively inhibited the excessive proliferation of repair cells, such as epidermal cells, vascular endothelial cells, and prevented the excessive secretion and deposition of extracellular matrix proteins.…”