“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

Abstract

Wound infection and excessive exudate can affect the process of wound healing. However, the disadvantage of the anti-microbial wound dressings is that the biological fluids are ineffectively removed. Inspired by making “Chinese Jianbing”, a composite wound nano-dressing was developed consisting of a hydrophilic outer layer (chitosan&polyvinyl alcohol: CTS-PVA) and a hydrophobic inner layer (propolis&polycaprolactone: PRO-PCL) by combining casting and electrospinning methods for effective antibacterial and unidirectional removing excess biofluids. In vitro, the composite wound nano-dressing of PRO-PCL and CTS-PVA (PPCP) could strongly inhibit Pseudomonas aeruginosa. Furthermore, PPCP wound dressing had excellent antioxidant properties and blood coagulation index for effective hemostatic. Importantly, it had a preferable water absorption for removing excess biofluid. In vivo, it had anti-inflammatory properties and promoted collagen Ⅰ preparation, which realized 80% wound healing on day 7. In short, the PPCP wound dressing provides a new direction and option for antibacterial and removes excess biofluid.

A Mechanically Resilient and Tissue‐Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care

“…First, the blood compatibility of the hydrogel was evaluated by performing a hemolysis assay. [ 40 ] The hydrogel‐conditioned erythrocyte solutions were examined to verify whether the destruction of red blood cells and the release of hemoglobin occur. The liquid was centrifuged to separate hemoglobin from the supernatant.…”

Exploring the mechanism of Huanglian ointment in alleviating wound healing after anal fistula surgery through metabolomics and proteomics

“…In vitro, this composite nanomaterial effectively inhibits the growth of Pseudomonas aeruginosa, exhibits good antioxidant properties, and has hemostatic effects. In vivo, it suppresses inflammation, promotes collagen synthesis, and accelerates wound healing [ 14 ]. Jiang Tang Xiao Ke (JTXK), a traditional Chinese medicine formula, which promotes wound healing in Staphylococcus aureus-infected wounds by modulating miR-139-5p-mediated neutrophil proliferation and differentiation [ 15 ].…”

Fast and convenient delivery of fluidextracts liquorice through electrospun core-shell nanohybrids

“…Today, electrospinning, as a useful nanofiber fabrication method, has spread into almost all scientific applied fields ( Pang et al, 2021 ; Li et al, 2022 ; Wang et al, 2023 ; Wang et al, 2023 ; Geesi et al, 2023 ), including several biomedical applications, such as tissue engineering, regeneration medicine, and wound dressing ( Khazaeli et al, 2020 ; Niu et al, 2021b ; Li et al, 2021 ; Maleki et al, 2021 ; Zhao H. et al, 2022 ; Gao et al, 2022 ; Liang et al, 2022 ). Particularly in pharmaceutics, it is regarded as a popular pharmaceutical nanotechnology ( Spizzirri et al, 2021 ; Chen et al, 2022 ; Wang et al, 2022 ).…”