Endocrinology: The ovarian hyperstimulation syndrome in in-vitro fertilization: a Belgian multicentric study. I. Clinical and biological features

Delvigne, Annick; Demoulin, A; Smitz, Johan; Donnez, Jacques; Koninckx, Philippe; Dhont, Marc; Englert, Yvon; Delbeke, L.; Darcis, L; Gordts, Stephan; Puttemans, Pierre; Gerris, Jan; Schoysman, R; Leroy, Fernand

doi:10.1093/oxfordjournals.humrep.a138260

Cited by 141 publications

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“…Data regarding the frequency of VTE, however, comprise predominantly of case reports, case series, and relatively small cohort studies (Table S6). [116][117][118][119][120][121] In two large retrospective series of patients undergoing in vitro fertilization, thrombosis complicated 0.1% (95% CI, 0%-0.3%) 116 and 0.3% (95% CI, 0%-0.8%) 117 of cycles. A hospital-based case-control study demonstrated a fourfold increase in antenatal VTE with assisted reproductive technology for singleton pregnancies and a sixfold incidence in twin pregnancies but no statistically signifi cant association with postpartum VTE.…”

Section: Vte In Patients Using Assistedmentioning

confidence: 99%

VTE, Thrombophilia, Antithrombotic Therapy, and Pregnancy

Bates

Greer

Middeldorp

et al. 2012

Chest

1,286

591

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Summary of RecommendationsNote on Shaded Text: Throughout this guideline, shading is used within the summary of recommendations sections to indicate recommendations that are newly added or have been changed since the publication of Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Recommendations that remain unchanged are not shaded. Abbreviations: APLA 5 antiphospholipid antibody; aPPT 5 activated partial thromboplastin time; HIT 5 heparin-induced thrombocytopenia; INR 5 international normalized ratio; LMWH 5 low-molecular-weight heparin; NNT 5 number needed to treat; PE 5 pulmonary embolism; RR 5 risk ratio; UFH 5 unfractionated heparin

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Section: Vte In Patients Using Assistedmentioning

confidence: 99%

VTE, Thrombophilia, Antithrombotic Therapy, and Pregnancy

Bates

Greer

Middeldorp

et al. 2012

Chest

1,286

591

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“…Sex hormones are the major difference between female and male, and the effect of estrogen on coagulation is sometimes discussed, but controversy still remains. High estrogen level is associated with increased risk of ovarian hyperstimulation syndrome (OHSS, [8,9]) which may cause thrombosis [10][11][12], while estrogen has an antithrombotic effect on hormone replacement therapy (HRT) which may prevent coronary artery disease [13][14][15][16] and stroke [17,18]. Moreover, oral contraceptives are known to increase the risk of thrombosis [19][20][21][22][23][24][25].…”

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confidence: 99%

Sex Difference in Platelet Aggregation Detected by New Aggregometry Using Light Scattering.

et al. 2001

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Abstract.Earlier studies in platelet aggregation have shown that females seemed to have greater aggregability than males as detected by conventional aggregometry which used light transmission (LT), but controversy still remains. This study was performed to determine whether sex difference exists in platelet aggregation by using the recently developed laser light scattering (LS) method, which can detect small aggregates (i.e., two or three platelets). Blood was drawn from healthy volunteers (10 male and 10 female in follicular phase after menstruation), and platelet aggregation was detected by either LT or LS method in platelet rich plasma.Platelet aggregation was stimulated by increasing concentration of adenosine 5 diphosphate (ADP, 0, 0.5, 1 and 2 pM). To detect the effect of sex hormones, platelets were incubated with estradiol (10 nM) or testosterone (40 nM) for 30 min, then platelet aggregation studies were performed.LT method revealed that female had greater aggregability than male. With weak stimuli (<_ 1,iM ADP), LS method showed that females had more medium aggregates than males, and that testosterone decreased small aggregates, and that estradiol decreased all sizes of aggregates. These data suggest that the female is more conductive to platelet aggregation than the male at a physiologic concentration of ADP (<-1 reM), but that both estradiol (10 nM) and testosterone (40 nM) have countereffects on platelet aggregation at the same condition. Therefore, the reason why females have greater aggregability than males may partly be explained by their lack of testosterone, but the mechanism still remains to be elucidated. has life-threatening bleeding during perinatal period. Some studies, however, have pointed out that the results in aggregometry between female and male are controversial [3,4]. The recently developed light scattering (LS) method has greater sensitivity than conventional LT method [5], since the LT method cannot detect small aggregates with less than 100 platelets, whereas the LS method can detect aggregates as small as two or three platelets [b, 7] . We applied this new method to exploring the sex differences in platelet aggregation. Sex hormones are the major difference between female and male, and the effect of estrogen on coagulation is sometimes discussed, but controversy still remains. High estrogen level is associated with

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“…4,17,18 PCOS patients undergoing IVF have a high risk of developing ovarian hyperstimulation syndrome (OHSS), a serious iatrogenic complication of ovarian stimulation triggered by exogenous and/or endogenous hCG. 19 The introduction of GnRH antagonists in recent years with an established decrease in the incidence of OHSS as compared with GnRH agonists in the general population, might offer a new safer treatment option for these patients. 20,21 Gonadotrophin-releasing hormone (GnRH) antagonist is being increasingly used in COS for IVF from late 1990s.…”

Section: Introductionmentioning

confidence: 99%