Endocrinology and Dialysis: Management of Lipid Abnormalities Associated with End‐Stage Renal Disease

Liu, Jia; Kalantarinia, Kambiz; Rosner, Mitchell H.

doi:10.1111/j.1525-139x.2006.00193.x

Cited by 12 publications

(12 citation statements)

References 130 publications

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“…Several investigations, including the present one, have shown that ESRD patients mainly have more elevated TG and non-HDL-C but not LDL-C (14,28). This may partially explain why the association between fetuin A and dyslipidemia occurs mainly on the non-HDL-C and TG components.…”

Section: Discussionmentioning

confidence: 58%

Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Chen¹,

Chiu²,

Hsu³

et al. 2009

European Journal of Endocrinology

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Background: Fetuin A, a predictor of cardio-vascular (CV) mortality in dialysis patients has been associated with dyslipidemia in non-diabetic coronary artery disease. Truncal obesity is linked to dyslipidemia and also predicts CV mortality. This study had aimed to investigate the associations among fetuin A, truncal obesity, and dyslipidemia in hemodialysis (HD) patients. Methods: One hundred and nine non-diabetic HD patients were evaluated. Waist circumference, highly sensitive C-reactive protein (hs-CRP), fetuin A, and lipoprotein levels (i.e. total cholesterol (T-CHO), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), non-HDL-C, and triglyceride (TG)) were measured for analysis of correlations. The patients were divided into tertiles by fetuin A concentrations. Results: Data from 63 women and 46 men aged 60G13 years were analyzed. Patients in the highest tertile of fetuin A (0.33-0.51 g/l) had higher serum creatinine, albumin, T-CHO, LDL-C, non-HDL-C, and TG, more truncal obesity and lower hs-CRP than patients in the lowest tertile (all P!0.05). In multi-variable linear regression analysis, fetuin A was independently associated with TG level and total iron binding capacity after adjustments for age, hemoglobin, albumin, calcium, body mass index, and hs-CRP. Patients in the highest fetuin A tertile had 3.2-and 4.4-fold higher incidence of truncal obesity (PZ0.038) and hyper-triglyceridemia (PZ0.015) independent of nutritional status and inflammation. Conclusion: Fetuin A is positively associated with truncal obesity and dyslipidemia, which are independent of malnutrition and inflammation. It may predict visceral adiposity and dyslipidemia, especially TG and TG-rich lipoproteins, in HD patients.

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Section: Discussionmentioning

confidence: 58%

Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Chen¹,

Chiu²,

Hsu³

et al. 2009

European Journal of Endocrinology

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“…22,23 We also found that in the PD group, patients have higher cholesterol and Apo-B levels than in HD group, as reported previously. 7,24,25 A possible explanation for this abnormality is the exposure of patients to glucose in the dialysate and insulin resistance that activates the delivery of free fatty acids (FFAs) to the liver and subsequently the oxidation or esterification of FFAs to cytosolic triglycerides or VLDL. 26,27 The increase of Apo-B concentration in PD patients may possibly enhance the production of Apo-B containing, triglyceride-rich atherogenic particles.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Lipid abnormalities mainly include low levels of highdensity lipoprotein cholesterol (HDL-C), high levels of triglycerides, and elevated levels of triglyceride-rich lipoproteins or lipoprotein remnants. [5][6][7] During oxidative stress, low-density lipoprotein cholesterol (LDL-C) is susceptible to oxidative modification to oxidized LDL (oxLDL). The latter acts as chemoattractant for monocytes and triggers inflammatory reactions within the arterial wall, such as monocyte adhesion to foam cells and monocyte differentiation into macrophages.…”

Section: Introductionmentioning

confidence: 99%

Lipid Abnormalities and Oxidized LDL in Chronic Kidney Disease Patients on Hemodialysis and Peritoneal Dialysis

et al. 2011

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Dyslipoproteinemia and oxidative modification of low-density lipoprotein (oxLDL) contribute to the development of oxidative stress and atherosclerosis in chronic kidney disease (CKD). On the contrary, high-density lipoprotein cholesterol (HDL-C), especially HDL3-C subtype, has protective effect against oxidative damage. There is limited evidence referring HDL-C subclass levels in patients on dialysis. This study was designed to compare lipid abnormalities and oxLDL levels in hemodialysis (HD) and peritoneal dialysis (PD) patients. Serum lipids, HDL subclasses, and oxLDL were measured in 55 patients with CKD-stage 5 (31 patients on HD and 24 patients on PD) and in 21 normal controls (NC). The results showed that in dialysis patients, triglycerides were higher than in controls (p < 0.0001) and HDL-C was significantly lower (p < 0.0001). The HDL2-C subclass concentration did not differ significantly between patients and controls, while HDL3-C was lower in patients (11 ± 0.5 mg/dL) than in NC (23 ± 1, p < 0.0001). oxLDL levels were markedly increased in patients (1.92 ± 0.29 mg/L) compared to NC (0.22 ± 0.05, p < 0.0001). Patients on PD had higher levels of cholesterol (p < 0.001) and apolipoprotein B (p < 0.05) than patients on HD. However, HDL-C, HDL-C subclasses, and oxLDL concentrations did not differ significantly between PD and HD patients. It is concluded that patients with CKD have a nearly 10-fold elevation of oxLDL compared with NC. Patients on PD have differences in the lipid profile compared with patients on HD; however, both modalities seem to possess similar potential to atherosclerosis development.

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“…Lipid abnormalities are common in kidney disease [100,101] and contribute to a high incidence of cardiovascular disorders in this population. Plasma and erythrocyte lipid profiles were examined in CRF patients on hemodialysis for 30 months [102].…”

Section: Effect Of Chronic Kidney Disease and Glomerulonephritismentioning

confidence: 99%

Plasma lipidomics reveal profound perturbation of glycerophospholipids, fatty acids, and sphingolipids in diet-induced hyperlipidemia

Miao

Chen

Pei

et al. 2015

Chemico-Biological Interactions

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Endocrinology and Dialysis: Management of Lipid Abnormalities Associated with End‐Stage Renal Disease

Cited by 12 publications

References 130 publications

Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Lipid Abnormalities and Oxidized LDL in Chronic Kidney Disease Patients on Hemodialysis and Peritoneal Dialysis

Plasma lipidomics reveal profound perturbation of glycerophospholipids, fatty acids, and sphingolipids in diet-induced hyperlipidemia

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