Endocrine, nutritional, and metabolic diseases

Nesterova, Anastasia P.; Klimov, Eugene; Zharkova, Maria; Sozin, Sergey; Соболев, В. В.; Ivanikova, Natalia V.; Шкроб, М. А.; Yuryev, Anton

doi:10.1016/b978-0-12-817086-1.00004-x

Cited by 5 publications

(5 citation statements)

References 126 publications

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“…At present DM is one of the most frequent disease among elderly patients and prevalence of DM type 2 has rapidly increased in last decades in most industrialized countries due to lifestyle changes [ 29 ]. Both diabetic microangiopathy and diabetic neuropathy are known side-effects of DM, which are associated with prolonged, restrictive wound healing process [ 25 , 26 , 30 ]. As a consequence, we hypothesized that concomitant DM was associated with lower chances of short-term urinary continence recovery in PCa patients undergoing RP.…”

Section: Discussionmentioning

confidence: 99%

Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy

Philippi

Mandel

Hohenhorst

et al. 2022

Cent european J Urol

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Introduction The aim of this article was to test the impact of diabetes mellitus (DM) on short-term urinary continence in patients undergoing radical prostatectomy (RP). Material and methods We relied on an institutional tertiary-care database to identify patients who underwent RP between 11/2018 and 02/2021 with data available on short-term urinary continence status (30–90 days post-surgery). Continence was defined as the usage of no or one safety-pad within 24 hours. Univariable and multivariable logistic regression models tested the correlation between DM and short-term continence. Covariates consisted of pathological T-stage, body mass index, prostate volume, surgical approach and nerve-sparing. Results Of 142 eligible patients, 15 (11%) patients exhibited concomitant DM. Patients diagnosed with DM exhibited lower continence rates at short-term follow-up compared to patients without DM (33 vs 63%, p = 0.03). In univariable and multivariable logistic regression models, DM was strongly associated with reduced chances of short-term urinary continence recovery (multivariable odds ratio [OR]: 0.26, 95%-CI: 0.07–0.86; p = 0.03). Furthermore, pathological T-stage (pT3/pT4) was additionally associated with reduced chance of urinary continence in logistic regression models (multivariable OR: 0.43, 95%-CI: 0.19–0.94; p = 0.04). Other covariables failed to reach statistical significance in multivariable logistic regression analyses predicting urinary continence. Conclusions DM was associated with lower chances of short-term urinary continence recovery in a contemporary cohort of patients undergoing radical prostatectomy. Patients with DM should be preoperatively informed and intensified, postoperative pelvic floor training should be considered in this subgroup of RP patients.

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Section: Discussionmentioning

confidence: 99%

Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy

Philippi

Mandel

Hohenhorst

et al. 2022

Cent european J Urol

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“…There is evidence that long-chain saturated fatty acids activate certain transcription factors that target lipogenic target genes, sometimes leading to negative health effects. During type 2 diabetes progression, long-chain saturated fatty acids trigger cell apoptosis and increase oxidative stress [ 23 ]. Chronic exposure to long-chain saturated fatty acids is a risk factor for beta-cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Relationship between gut microbiome diversity and hepatitis B viral load in patients with chronic hepatitis B

et al. 2021

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Background Hepatitis B virus (HBV) infection is associated with a reduced risk of developing dyslipidemia and non-alcoholic fatty liver diseases. Given that the gut microbiota plays a significant role in cholesterol metabolism, we compared the differences in gut microbial diversity and composition between HBV-infected and uninfected subjects. Results A prospective case–control study was designed comprising healthy controls (group A) and HBV-infected individuals (group B) in a 1:1 ratio (57 participants each; total = 114). The patients in group B were divided into two subgroups according to their HBV DNA loads: B1 < 2000 IU/mL (N = 40) and B2 ≥ 2000 IU/mL (N = 17). In a pairwise comparison of HBV-infected individuals and controls, higher alpha diversity was noted in group B, and the difference was significant only in patients in group B1. Alloprevotella and Eubacterium coprostanoligenes were predominant in group B1 compared to the control, whereas the abundance of Bacteroides fragilis and Prevotella 2 was lower. Conclusions The gut microbiome in HBV-infected individuals with a low viral load is highly diverse and is dominated by specific taxa involved in fatty acid and lipid metabolism. To our knowledge, this is the first demonstration of a correlation between the presence of certain bacterial taxa and chronic HBV infection depending on the load of HBV DNA.

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“…Dissolution experiments in SLFs were carried out to analyze the elements that dissolve from the dust samples and were in contact with the SLF for 24 h. Gamble's solution (GS) and artificial lysosomal fluids (ALF) were used as simulated lung fluids following the preparation shown in Table S1 [9,22]. GS simulated the pulmonary surfactants secreted by cells in the interstices of the lungs, and ALF simulates the acid fluid in macrophages that is in charge of trap and eliminate foreign bodies [8]. To simulate body conditions, experiments were run in a dark room, double jacketed bottles were used to circulate water at 37 • C and keep temperature constant, and the SLF were oxygenated for 5 min at a rate of 5 L/min before starting the experiments.…”

Section: Dissolution Experimentsmentioning

confidence: 99%

“…A portion of dust may be retained by the mask (if worn properly) and in the upper part of the respiratory system. Large particles may be eliminated via mucocilliary clearance [8]. Smaller particles penetrate deep into the lungs and are deposited in the alveolar region.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Toxicity Analysis of Lab-Created Respirable Coal Mine Dust from the Appalachians and Rocky Mountains Regions

et al. 2022

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Coal mine workers are continuously exposed to respirable coal mine dust (RCMD) in workplaces, causing severe lung diseases. RCMD characteristics and their relations with dust toxicity need further research to understand the adverse exposure effects to RCMD. The geographic clustering of coal workers’ pneumoconiosis (CWP) suggests that RCMD in the Appalachian region may exhibit more toxicity than other geographic regions such as the Rocky Mountains. This study investigates the RCMD characteristics and toxicity based on geographic location. Dissolution experiments in simulated lung fluids (SLFs) and in vitro responses were conducted to determine the toxicity level of samples collected from five mines in the Rocky Mountains and Appalachian regions. Dust characteristics were investigated using Fourier-transform infrared spectroscopy, scanning electron microscopy, the BET method, total microwave digestion, X-ray diffraction, and X-ray photoelectron spectroscopy. Inductively coupled plasma mass spectrometry was conducted to determine the concentration of metals dissolved in the SLFs. Finer particle sizes and higher mineral and elemental contents were found in samples from the Appalachian regions. Si, Al, Fe, Cu, Sr, and Pb were found in dissolution experiments, but no trends were found indicating higher dissolutions in the Appalachian region. In vitro studies indicated a proinflammatory response in epithelial and macrophage cells, suggesting their possible participation in pneumoconiosis and lung diseases development.

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Endocrine, nutritional, and metabolic diseases

Cited by 5 publications

References 126 publications

Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy

Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy

Relationship between gut microbiome diversity and hepatitis B viral load in patients with chronic hepatitis B

Characterization and Toxicity Analysis of Lab-Created Respirable Coal Mine Dust from the Appalachians and Rocky Mountains Regions

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