Endocrine mucin‐producing sweat gland carcinoma: A study of 11 cases with molecular analysis

Abstract

This series provides further histopathologic support that EMPSGC represents a multistage progression to mucinous carcinoma. Additional studies are needed to understand its molecular mechanisms.

Delayed treatment of endocrine mucin–producing sweat gland carcinoma initially diagnosed as a chalazion

“…Of the 11 cases, 7 were interpreted as either chalazion or nonspecific inflamed lesions of the eyelid. Inflamed lesions most commonly represent chalazia or acute hordeola 4 . At first, this patient presented with a clinical appearance similar to that of a chalazion, prompting its misdiagnosis and anti-inflammatory treatment over an extended period.…”

“…Although mucinous carcinoma and EMPSGC were not included in Ozdal's analysis, we know EMPSGC has a high risk of misdiagnosis because of its rarity. Qin et al 4 performed a case review of 11 cases of EMPSGC all in the eyelid. Of the 11 cases, 7 were interpreted as either chalazion or nonspecific inflamed lesions of the eyelid.…”

Endocrine Mucin–Producing Sweat Gland Carcinoma: Two New Eyelid Cases and Review of the Literature

“…1 It tends to occur in elderly patients and is mostly encountered in the sixth and seventh decades of life. [1][2][3][4][5][6] It is more prevalent in females than males. [1][2][3][4][5] Facial sites are mostly described with predilection for periocular skin, particularly the eyelids.…”

“…[1][2][3][4][5][6] It is more prevalent in females than males. [1][2][3][4][5] Facial sites are mostly described with predilection for periocular skin, particularly the eyelids. [1][2][3][4][5][6] Clinically, it presents as a nodular growth or a nondistinctive swelling and is often mistaken as basal cell carcinoma or other benign entities.…”

“…[1][2][3][4][5] Facial sites are mostly described with predilection for periocular skin, particularly the eyelids. [1][2][3][4][5][6] Clinically, it presents as a nodular growth or a nondistinctive swelling and is often mistaken as basal cell carcinoma or other benign entities. 1,6,7 Histologically, EMPSGC is considered by some authors as the skin counterpart of solid papillary carcinoma of the breast due to morphological and immunohistochemical similarities.…”